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Study Finds Cannabis Compounds Prevent Infection By Covid-19 Virus

Researchers have found that two cannabinoid acids commonly found in hemp varietals of cannabis, cannabigerolic acid, or CBGA, and cannabidiolic acid, also known as CBDA, can bind to the spike protein of SARS-CoV-2, the virus that causes Covid-19. By binding to the spike protein, the compounds can prevent the virus from entering cells and causing infection, potentially offering new avenues to prevent and treat the disease.

Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, in collaboration with scientists at the Oregon Health & Science University.

By binding to the spike protein, the compounds can prevent the virus from entering cells and causing infection, potentially offering new avenues to prevent and treat the disease. Compounds in cannabis can prevent infection by the virus that causes Covid-19, according to research. “Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2,” the researchers wrote in an abstract of the study.

The study was led by Richard van Breemen

01/20/22 Richard van Breemen – Newly published research shows that compounds in hemp may prevent coronavirus from entering human cells. Lead author Richard van Breemen, PhD, a Professor of Medicinal Chemistry in the Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, and a Principal Investigator at the Linus Pauling Institute.

 

  Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, in collaboration with scientists at the Oregon Health & Science University. Van Breeman said that the cannabinoids studied are common and readily available. “These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said, as quoted by local media. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans.” Van Breemen added that CBDA and CBGA blocked the action of emerging variants of the virus that causes Covid-19, saying that “our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

Corona viruses close up

CBGA and CBDA prevented infection from the virus that causes Covid-19 by binding to its spike protein is the same part of the virus target by Covid-19 vaccines and antibody therapies. In addition to the spike protein, SARS-CoV-2 has three more structural proteins as well as 16 nonstructural proteins and several compounds van Breemen characterized as “accessory” proteins, all of which are potential targets for drugs developed to prevent Covid-19. “Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” van Breeman said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.” Although further research is needed, van Breemen noted that study shows the cannabinoids could be developed into drugs to prevent or treat Covid-19. “These compounds can be taken orally and have a long history of safe use in humans,” van Breemen noted.

“They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.” Van Breeman also noted that the research showed the cannabinoids were effective against new variants of the virus, which he said are “one of the primary concerns” in the pandemic for health officials and clinicians. “These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen,” said van Breemen.

“Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.” The researcher added that “resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2.” For More on the Global Hemp Innovation Center, OSU click on the next message. With the launch of the Global Hemp Innovation Center, OSU restores its original position as the nation’s premier hemp research institution.

OSU was the site of the country’s only hemp research center from the 1880s to the 1930s. We are the largest comprehensive hemp research center in the nation with 40 faculty across 19 disciplines conducting research in 10 locations across the state and four locations around the world in Asia and Europe. As the only hemp seed certifier in the state, and one of only four in the country, OSU is able to provide growers access to a source of certified seed for planting in the state.

Van Breemen said resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2. “Our earlier research reported on the discovery of another compound, one from licorice, that binds to the spike protein too,” he said. “However, we did not test that compound, licochalcone A, for activity against the live virus yet. We need new funding for that.” Timothy Bates, Jules Weinstein, Hans Leier, Scotland Farley and Fikadu Tafesse of OHSU also contributed to the cannabinoid study.
About the OSU College of Pharmacy: The College of Pharmacy prepares students of today to be the pharmacy practitioners and pharmaceutical sciences researchers of tomorrow by contributing to improved health, advancing patient care and the discovery and understanding of medicines.
In a study published just last week in the Journal of Natural Products, researchers from Oregon looked to hemp (Cannabis sativa L.) as a botanical source for potential ligands of the SARS-CoV-2 spike protein and its variants – and their results are taking the medical cannabis field by storm. Magnetic microbead affinity selection screening (MagMASS) – an affinity selection-mass spectrometry (AS-MS) approach – accompanied by ultra-high-pressure liquid chromatography-mass spectrometry (UHPLC-MS) analyses were used to identify and characterize ligand-receptor (i.e., viral spike protein-cannabinoid) interactions. Confirmation with supplemental cannabinoid standard assays revealed that cannabigerolic acid (CBGA), tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA) are indeed ligands with high respective binding affinities for the spike protein – especially relative to those of Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-tetrahydrocannabinol, (Δ8-THC) cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), and cannabidiol (CBD), which exhibited weak if any, binding. The authors suggest that CBGA’s strong binding to the spike protein while in the presence of other cannabinoids is likely because CBGA is binding the protein allosterically, thus evading competition with orthosteric cannabinoid ligands for binding. Due to the ‘controlled substance’ status of THCA, further experiments could not be pursued on this cannabinoid. CBGA and CBDA, on the other hand, were subjected to further assessment of their respective binding affinities and antiviral activities. Virus neutralization assays demonstrated that CBGA and CBDA could prevent infection by a pseudovirus expressing the SARS-CoV-2 spike protein in human epithelial cells. More importantly, these two cannabinoids inhibited cellular entry of live SARS-CoV-2 in vitro. Furthermore, CBGA and CBDA were each equally as effective against the alpha variant, B.1.1.7, and the beta variant, B.1.351.
 
   

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30%-50% of the adult population struggle with chronic insomnia. Will CBD be THE Answer?

 

 

According to the National Sleep Foundation, between 30%-50%

of the adult population struggle with chronic insomnia.

If you do not know what insomnia is, it is a problem that inhibits the ability to fall asleep quickly or to maintain a healthy, undisturbed sleep through the night. Many people have found that using cannabis to help them sleep is a natural and effective way to crush insomnia. Insomnia sufferers know the constant struggle of trying out different sleeping pills with the hope that they will get a good-night’s sleep.

Using sleeping pills and other pharmaceutical medications can have negative side effects on mental development and one’s sleep cycle. How does cannabis help your sleep? Many insomnia sufferers, of the adult population, have found relief by introducing marijuana use into their evening routine to help them settle for a good night of sleep. The science behind how cannabis can help you sleep is very in-depth and boring.

So, we will try to sum it up as best as possible. Basically, the human body has a system called the endocannabinoid system, which is a system of endocannabinoids (neurotransmitters) that bind to cannabinoid receptors and cannabinoid proteins which are found along the vertebrate central nervous system (including the brain). No big surprise that cannabinoids are actively found in cannabis — specifically THC.

Current Research has been conducted to understand the relationship between cannabis and insomnia. Cannabis contains active constituents called Phyto cannabinoids which have been known to have several different medicinal benefits. One of these benefits is sedation and noted improvements in sleep. This study stated that a survey conducted in 2017 concluded that nearly two thirds of all participants with disturbed sleep habits completed stopped using pharmaceutical sleep aids after switching to medical cannabis use. It is important to note that the topic of cannabis and sleep is still being researched and left with many unanswered questions. There is conflicting research about withdrawal symptoms, and whether THC or CBD are more beneficial actives in cannabis for sedation.

THC & CBD Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two main actives found in cannabis. These two actives are what bind to the receptors in the body’s endocannabinoid system. Both THC and CBD are psychoactive components, however, they react very differently in the body. THC is what causes the high sensation in the body, while CBD is known for helping with depression and anxiety. When research began about the relationship between cannabis and sedation began, researchers believed the THC was the main activity that induced sedation in the body. As research continues, CBD has been studied to provide the same relaxation effects which could lead to better sleep as well. People who tend to have high anxiety may choose a CBD product instead of a THC heavy product because of the possibility that the THC could increase anxiety and paranoid feelings.

As of recently, CBD oils can be purchased that can provide similar effects but do not require smoking marijuana. CBD oils will not get y0u high. Best Cannabis Strains for Sleep Listed below are some recommendations for marijuana strains you can use when finding which one will work best for you. While some of these may work for other people, they could not be right for you and your body, so make sure you take these recommendations as a learning opportunity.

You will have to try a few of them out before you find one that works well for you. People often choose Indica strains for sleep as they possess more of a body-high sensation and induce heaviness and laziness. Sativa strains can also be beneficial for sleep since your body typically crashes harder after the head high slows down. Finding the type of strain that is right for you will take some experimenting, so enjoy the process.  

 

 

 

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hempsmart™ A Brand you can Trust in 2022

hempsmart™ A Brand you can Trust in 2022

 

A Brand you can Trust

MCOA’s wholly owned subsidiary hempsmart™ is a CBD company focused on creating and promoting the most effective, best tasting, and highest quality products on the market. We are industry leaders in premium CBD with proprietary botanical ingredients and LAB TESTED products that support the wisdom of every cell in the body. MCOA 2022 has expanded into the global cannabis marketplace with hempsmart™ products promoting, a healthy lifestyle including positive mental and physical wellness.  Our brand promise affirms our commitment to serving customers with proven products that promote a more positive lifestyle including mental and physical wellness. hempsmart™ rebrand unveils a fresh take on its packaging and e-commerce website for hempsmart™ premium CBD organic products.  The new site includes an educational component for CBD and the Cannabis industry.  By offering useful news and relevant information, it is MCOA’s goal to have hempsmart.com become recognized as a leading source for CBD products and industry updates. The new platforms for MCOA and hempsmart™ will engage customers via social media—Instagram, Twitter, Tik Tok, and more which will generate a new loyal group of followers. hempsmart™ premier products include its Smart Drops (CBD Drops), Neuro Smart (Patented Brain Pills), and Smart Cream (Pain Cream) brands. These organic, plant-based products help to manage anxiety, pain and insomnia without the inclusion of THC. Shop & Join the Community Today!  LEARN MORE
 

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Statements in this website have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new wellness or dietary program. Please view our full terms of use agreement for more information and the terms and conditions governing your use of this site. Cannabidiol (CBD) is a natural derivative of cannabis plants that promote and support nutrition, health and wellness, as well as anti-aging. Source: US Government Patent #6,630,507: “cannabinoids as antioxidants and neuroprotectants.” Marijuana Company of America, Inc. (MCOA) does not sell or distribute any products that are in violation of the United States controlled substances act (US CSA) in California. MCOA grows, produces, sells and distributes solutions for health, wellness, and anti-aging companies. MCOA solutions include cannabis- and/or CBD/CBN-based elements. Where allowed, MCOA may sell or distribute solutions containing THC. For more information, please contact us.   Marijuana Company of America · MCOA · Diversified Holding Company
 
   

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What the Best Hemp Manufacturers Have Learned from the Wine Industry

Any experienced wine aficionado can tell with one sip the geographic area where the grapes used to create a wine were grown. Wine inherits characteristics from the soil where the grapes were grown, the climate of the site that produced it, and the practices of the winemaker. There are currently 252 AVAs in 33 states across the country.

As grape cultivation and winemaking increased across the United States over the past 50 years, smaller wineries began producing more wines from locally grown varietals.

Today, there are wineries in all 50 states, and more parts of the country are developing their own “wine countries.”

What was once considered a solely New York state or California industry has expanded to include Oregon, Washington, Texas, and Colorado.

Colorado now touts more than 130 licensed wineries and nearly 1,000 acres of vineyards producing more than 150,000 cases of wine a year.

.

Although the burgeoning hemp and CBD industry in the United States has not yet reached this level of sophistication, there is every indication it is evolving in that direction.

And there is an excellent reason: The similarities between the two crops and their resulting products are many. Winemakers choose the genetics and agricultural regions for their desired characteristics.

Just as the Willamette Valley in Oregon has the ideal microclimate for the flavors and other features of a pinot noir,

the High Rockies of Colorado are ideal for creating some of the finest terpene profiles in the cannabis or the hemp plant. 

For both wine and hemp, small-batch producers make the most desired and highest-quality products on the market.

While CBD available at any roadside gas station or convenience store may have become commonplace, true connoisseurs of craft products crave uniqueness and attention to quality.

And these consumers are actively searching for and finding small-batch products that exceed their previous expectations of CBD>

American Viticultural Areas

 

 

When a U.S. winery wants to tell you the geographic pedigree of its wine, it uses a tag on its label called an Appellation of Origin. Appellations are defined either by political boundaries, such as the name of a county, state or country, or by federally-recognized regions called American Viticultural Areas (AVAs).

In order for a wine to be designated with an Appellation of Origin defined by a political boundary, such as a county name for example, federal law requires that 75 percent or more of grapes used to make the wine be from that appellation, and that the wine be fully finished within the state in which the county is located. A wine bearing “California” as an Appellation of Origin must, under state law, be made with 100% grapes that were grown and finished in the Golden State. View a list of California’s 58 counties and more detailed requirements for appellation use.

If a wine is designated with the name of an American Viticultural Area (AVA), federal regulations require that 85 percent or more of the wine is derived from grapes grown within the boundaries of that TTB-established AVA and that the wine is fully finished within the state or one of the states in which the AVA is located. Certain states have stricter standards for use of the name of an Appellation/AVA on wine labels.

>

 

 

Keep a ‘farmers first’ approach 

Smart CBD companies have recognized that quality products begin with quality hemp. This means being farmers first, and applying meticulous agriculture standards to hemp cultivation to produce consistent, high-quality CBD. When it comes to farming, giving each plant constant attention from the grower creates the best outcomes. Large-scale grows cannot provide plants with this personal touch. Also, smaller farms focused on quality can engage organic agricultural and responsible water use practices to cultivate each hemp plant carefully.  

 

 

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Thailand: Plans To Legalize Cannabis Consumption, Carrying And Home-Cultivation In 2022

The Ministry of Public Health of Thailand stated that it will push for the legalization of cannabis in 2022.

As reported by the Bangkok Post, the country had already removed cannabis stems and branches from its list

of category 5 narcotic substances but kept flowers and buds.

However, the new Narcotics Code, which came into force last Thursday, no longer includes cannabis and hemp.

According to the Thai newspaper, Health Minister Anutin Charnvirakul outlined the next goals in the regulation of the plant: “What we have achieved so far is to declare that cannabis stems, roots, and leaves are not drugs. Starting next year, we will remove everything – stems, roots, leaves, buds, flowers, and seeds – from the list of narcotic drugs.”

Cannabis And Hemp in Thailand the only exception to the new rule is that CBD extracts with a THC percentage higher than 0.2% will not be allowed.

Charnvirakul justified this by saying that “the figure has not been set unilaterally by Thailand. It is the standard of the World Health Organization.”

                                             World Health Organization

In the meantime, once the new narcotics schedule comes into effect, all cannabis-derived products (such as oil, soap, cosmetics, and supplements, which normally have less than 0.2% THC) will be authorized in the country.

The objective behind the relaxation of cannabis regulations is to stimulate the economy, agricultural tourism, and encourage people to grow and process cannabis to supplement their income.

Thus, residents of the country who wish to grow cannabis at home will be able to do so without quantity restrictions.

The only requirement is to obtain permission from local authorities before doing so.    

Is weed legal in Thailand?

Medical: Legal
Recreational: Illegal

The use of recreational cannabis in Thailand is illegal but cultivating it and using it for medical purposes is permitted, thanks to recent governmental policy updates. Here’s a look at how Thailand’s marijuana laws have evolved.

 

In the 1930s, as many countries around the world began regulating marijuana usage, Thailand got on board as well. In 1935 Thailand’s government passed the Cannabis Act, criminalizing the possession, sale, and use of the substance. In 1979, Thailand cracked down even further passing the Narcotics Act of B.E.2522 which ranked cannabis as a Category 5 drug. With the Thailand government’s strict drug penalization policies, this meant getting caught with large doses of marijuana could result in the death sentence!

Thailand’s weed laws remained unchanged until 2019 when the World Health Organization (WHO) changed weed’s classification from a Schedule IV to Schedule 1 ranking due to “evidence that some cannabis-based preparations have a medical use.”

Inquirer.net reported on how Thailand became the first Southeast Asian country to loosen its weed laws in turn with the passage of Narcotics Act (No. 7) B.E. 2562, which officially legalized the use of marijuana for medical purposes.

In January 2021, Thailand continued to loosen medical marijuana restrictions, legalizing the sale of food and cosmetics products containing cannabis leaves, stems, stalks, and roots. 

Thai sentiment toward marijuana

Cannabis, or Ganga as it is locally called, was once a major part of Thai people’s lives. Women used it to ease labor pains and men used it to ease back pains after a long day of physical labor. The hemp plant was also commonly used to season cooking and for the creation of locally worn fabrics. 

Today, with the new legalization of hemp products, cafes and restaurants such as S AM ARE, GTG Cafe and Kiew Kai Ka Cafe use CBD in their cuisine. Weed-loving visitors will be happy to find a wide range of cannabis-infused foods including omelets, salads, ice milk tea, cookies, and croissants, to name a few.

As for local sentiment towards its recreational use, a recent survey of 700 residents in Greater Bangkok, aged 20 to 59, revealed that over 64% are willing to try products containing low levels of THC Nikkei Research reported.

No, recreational marijuana is still illegal. Thanks to its heavy tourism industry, however, smoking weed in Thailand is a common sight on the beaches of Koh Phangan and Pai as well as in rasta bars. In city centers like Bangkok and Phuket however, you are far more likely to get caught and face criminal charges. 

What are the penalties for cannabis possession in Thailand?

Like many countries in Asia, Thailand has strict drug laws. Possession of 10 kg or more of marijuana with an intent to sell it can result in a 15 years prison sentence and a fine of 1.5 million baht (~USD$45,000). Getting caught with a small amount of marijuana for recreational usage can result in confiscation and fines, as well as dealing with the hassle of the local police, as many Reddit users warned. 

What are Thailand’s policies on medical cannabis and CBD-based products?

Thailand is at the forefront of the South-Eastern Asia medical marijuana front. On May 11, 2021 the country opened two full-time clinics dispensing cannabis oil for medical treatment. 

Additionally, Thailand has several government agencies and state-registered agricultural community programs for the cultivation and possession of cannabis. Hemp-based products with under .2% THC are legal. 

To help locally source hemp production, as well as generate increased local revenue, Thailand’s new prime minister passed legislation allowing households to grow up to 6 cannabis plants each, as reported by Bloomberg News. Similar to EU policies, Thai-grown cannabis plants must contain less than .2% THC, and be sold to the country’s medical facilities.

Thailand residents with approved health conditions can get a prescription from their doctor for marijuana use. Visitors wishing to bring in their medical marijuana may do so as well upon presenting their doctor’s prescription.

 

 

 

 


 

 

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