Over the past month, hemp entrepreneurs have traveled to the Florida State Capitol to advocate against a proposal to regulate hemp-derived products that could potentially hurt the hemp industry.
But Monday, many of those same professionals were cheering after the sponsor of the latest version of the bill removed any reference to limiting the THC dosage of those hemp-derived products. THC is the compound in the cannabis plant that can get you high.
In a committee meeting Monday, Manatee County House Republican Will Robinson Jr. said: “All caps are O.U.T., Out.”
Robinson was responding to a colleague, Democrat Anna Eskamani, of Orlando, on the committee. Robinson confirmed to her that his new amendment to the legislation would remove any references to capping the amount of THC in hemp products.
That means that products in hemp stores are not going to be affected in terms of their potency to consumers.
At the same time, the bill is still moving on issues regarding safety. The measure still maintains the safety requirements to keep products like Delta-8 THC out of the hands of those under age 21, provisions that aren’t remotely controversial and have been embraced by virtually everyone who has testified in three previous committee meetings held in the House and Senate.
“We’ve sure come a long way on this one,” said Florida Cannabis Action Network president Jodi James.
“You did a great job – saved a lot of businesses,” added William Clark from the Libertarian Party of Florida.
Carlos Hermida owns a hemp dispensary in Tampa and has attended previous committee meetings about the bill. He opted not to travel to Tallahassee Monday when he saw Robinson’s amendment added to the legislation last Friday.
“The public spoke and Robinson listened!” Hermida told the Phoenix in a text message. “I can’t help but be thankful to the representative for protecting the hemp industry and protecting our children.”
As originally written, Robinson’s bill HB 1475 (as well as a similar version in the state Senate) set limits on how much THC could be included per serving and per package of hemp products. Robinson raised the limits after the bill received its first hearing in a House committee, but hemp advocates said the limits still were far too low and would have made hemp-derived products less potent for consumers to purchase and thus threaten their businesses.
Robinson admitted that “there is more work to be done in this space,” but said that it was also a great indication that the committee process works. “It’s very important to take input from stakeholders and others,” he said.
The measure was unanimously approved by the House Infrastructure Committee, its third and final committee and now will go to the House floor. Its Senate equivalent (SB 1676) is scheduled to go before the Fiscal Policy Committee on Thursday of this week.
Did you ever wonder why cannabis doesn’t affect everyone the same way? Why do some people experience pleasure and relaxation when smoking pot and others get anxious or even paranoid?
To understand the various effects the same plant has on the same species, we humans that is, it’s essential to understand not only the plant and its components, but our own endocannabinoid system.
Enter neuroscience.
First things first, what is the endocannabinoid system?
Simply put, it is a biological system in the body that helps regulate and balance key bodily functions. An American psychiatrist with a private practice in San Francisco and Marin County focuses on addictions. In his book, “Marijuana on My Mind: The Science and Mystique of Cannabis,” Timmen L. Cermak, M.D. explores various questions about marijuana and its effects.
In his January post in Psychology Today, Cermak tries to explain how it feels to be high and why this experience can sometimes resemble meditation. In a new post, he focuses on “how THC and CBD ingestion produces pleasant effects for so many people, why too frequent use of cannabis can produce subtle cognitive and emotional impairments, and how selective use of cannabis has medicinal benefits for a variety of illnesses.”
Cermak looks at Koen Van Laere’s discovery of how genetic differences in the density of active CB1 receptors determine temperamental characteristics of extroversion exhibited in novelty-seeking and often risk-taking and introversion’s novelty and risk avoidance.
Cermak explains how THC increases endocannabinoid system activity, lowering the bar for experiencing novelty. This is why, when some people are, they notice things that they hadn’t noticed a long time ago, like the rainbow on each soap bubble. For some cannabis consumers, weed can help them become more fascinated with the everyday world.
On the other hand, too frequent cannabis use leads to raising the bar for experiencing novelty higher than normal, thus leading to a sense of boredom. “High cannabinoid activity produces novelty; low cannabinoid activity reduces novelty,” writes Cermak.
This means that people born with low CB1 receptors may feel good when THC increases their amygdala endocannabinoid system activity, as it “brightens their interest in the world.” On the other hand, people with high CB1 receptors who are already close to saturation with novelty could be overwhelmed with THC to the point of feeling anxious.
Temperament & Personality
Cermak notes an important distinction between temperament and personality when he says that “temperament is genetically determined and should not be conflated with personality.” He explains that two people with the same temperamental trait of novelty-seeking can develop two destructive personalities: “one becoming an inveterate world traveler while the other becomes ensnared in a series of drug addictions.”
In the end, Cermak highlights how Laere’s research offers a basis for understanding why the 20% reduction in CB1 receptors caused by frequent marijuana use could lead to temperament and ultimately personality changes. However, research confirming this theory would be unethical, so all we can do is trust anecdotes that indicate how regular marijuana use is related to various personality changes.
For More Information on Cannabis and CBD and YOU. Click On the Following Link
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Members of the Texas House of Representatives advanced legislation today seeking to expand the pool of patients eligible to obtain state-licensed cannabis products.
Lawmakers voted by a nearly five to one margin in favor of the legislation, House Bill 1805. Specifically, it amends the Texas Compassionate Use Program so that physicians may recommend certain products containing fixed levels of THC to patients with “a condition that causes chronic pain, for which a physician would otherwise prescribe an opioid.” It also empowers state health officials, rather than lawmakers, to add additional qualifying conditions. Currently, patients with autism, ALS, cancer, incurable neurological disorders, intractable epilepsy, multiple sclerosis, post-traumatic stress, and seizure disorders are eligible to obtain low-THC medical cannabis products.
The measure also amends limits on the amount of THC that may be present in state-licensed products.
“I am thrilled to see the proposed legislation advancing through the legislative process,” said NORML State Policies Manager Jax James, who also serves as Executive Director for Texas NORML. “Medical cannabis is an objectively safer alternative to the array of pharmaceutical drugs that it could potentially replace. I urge my fellow Texans to voice their support for this important legislation and to reach out to their Senators to encourage their backing as it moves through the legislative process.”
Texas lawmakers initially enacted legislation establishing the Compassionate Use Program in 2015. In 2021, legislators expanded the program to allow patients with PTSD and all forms of cancer to qualify for medical cannabis. That legislation also raised the limit on permissible levels of THC in licensed products from 0.5 percent to one percent.
When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.
1st Hemp USA News is a resource of Inspirational Technologies (2021-2023)Inspirational Technologies (2023) AllRightsReservedYour ONE STOP BLOG FOR INFORMATION, EDUCATION, & INSPIRATION OF ESSENTIAL INNOVATION & RENOVATION of You-THANK YOU FOR YOUR INTEREST*This site receives virtually no compensation for sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research, development, discovery and healing.Inspirational Technologies – is Committed to Your Health Wellness Beauty and EnrichmentReporting on Today’s Internal Botanical and Skin Product Benefits
4 Hemp Club was Inspired by Steven Smith’s vision to “Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.
Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the
4 Hemp key points being Health Hope and Happiness, thru Hemp“.
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April Rules is a colloquial term for April Fools, on current appropriate verbiage.
So, let it out. April does rule. It is the beginning of spring, and the hope for a new beginning, (aside from the tossed New Year’s resolutions).
This year the new collective bargaining agreement between the NBA and the National Basketball Players Association excluded any and all marijuana testing for players per The Athletic.
The NFL hosts franchises in many states where marijuana use is legal for medicinal and recreational use, but the “No Fun League” always fell back on the fact that it remains a controlled substance under federal law.
But now that more and more states are legalizing it, it seems the league might be moved to ban testing altogether, while still maintaining order among players who choose to indulge.
But the league’s current laws surrounding marijuana use and testing might not have anything to do with the substance itself, but rather, a political move. The NFL regards the marijuana ban as part of collective bargaining. This means that, before they get rid of it, they want something in return from the NFL Players Association.
Some believe this has already happened, or the league just refuses to enforce any violations, but it’s simply not the case. The NFL still levies harsh fines for positive tests, and multiple violations still mark players for the treatment program and potential suspensions.
But for how much longer?
Too soon to tell, but there’s no question the NBA’s decision to ban marijuana testing for players is a move other leagues will be monitoring closely.
We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology. We are often faced with our own personal conflicts which directly influence our interactions with our peers and family.
When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.
1st Hemp USA News is a resource of Inspirational Technologies (2021-2023)Inspirational Technologies (2023) AllRightsReservedYour ONE STOP BLOG FOR INFORMATION, EDUCATION, & INSPIRATION OF ESSENTIAL INNOVATION & RENOVATION of You-THANK YOU FOR YOUR INTEREST*This site receives virtually no compensation for sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research, development, discovery and healing.Inspirational Technologies – is Committed to Your Health Wellness Beauty and EnrichmentReporting on Today’s Internal Botanical and Skin Product Benefits
4 Hemp Club was Inspired by Steven Smith’s vision to “Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.
Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the
4 Hemp key points being Health Hope and Happiness, thru Hemp“.
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Alcohol Distributors for Federal Legalization of Marijuana are Asking Congress to Act Now.
Story by Jessica Gleman •
One of the largest alcohol distributors, Wine & Spirits Wholesalers of America (WSWA), has called on Congress to legalize marijuana on the federal level this month. The wholesaler argued the continued classification of cannabis as a Schedule I drug has “given rise to an untenable conflict between state and federal law.” WSWA wants Congress to enact regulations similar to that of alcohol.
In 2022, three more states legalized recreational weed, Rhode Island, Maryland and Missouri. There appears to be a growing trend of legalization sweeping the nation, as new measures appear on state election ballots each year. The number of states with legal marijuana will likely increase with every election.
“More than 50 percent of the U.S. population lives in a legal adult-use cannabis state,” read WSWA’s statement.
The statement continues, “The fact is cannabis legalization at the state level is here to stay, evidenced by nearly a decade of newly legalized state markets and no meaningful effort to undo them. Rather, states that have legalized are expanding their markets and even discussing ways to begin interstate commerce of the product. Yet they receive no support from the federal government in determining how to ensure that products are not hazardous or that the market is fair and competitive especially as the market becomes increasingly national in scope.”
A major problem under the current system means states where cannabis is legal face issues with banking or tax deductions because it is not federally legal.
The WSWA wants the federal government to legalize and regulate cannabis in a similar manner to alcohol, which would give distributors an avenue to make a lot of money. The US currently has a three-tier system for alcohol which makes distributors legally necessary middlemen between the producers and the retailers. Therefore, WSWA’s push for legalization is not a selfless act.
We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology. We are often faced with our own personal conflicts which directly influence our interactions with our peers and family.
When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.
1st Hemp USA News is a resource of Inspirational Technologies (2021-2023)Inspirational Technologies (2023) AllRightsReservedYour ONE STOP BLOG FOR INFORMATION, EDUCATION, & INSPIRATION OF ESSENTIAL INNOVATION & RENOVATION of You-THANK YOU FOR YOUR INTEREST*This site receives virtually no compensation for sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research, development, discovery and healing.Inspirational Technologies – is Committed to Your Health Wellness Beauty and EnrichmentReporting on Today’s Internal Botanical and Skin Product Benefits
4 Hemp Club was Inspired by Steven Smith’s vision to “Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.
Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the
4 Hemp key points being Health Hope and Happiness, thru Hemp“.
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Reported on the much-discussed scientific discovery of a THC analog thirty times more efficacious than the infamous D9-THC. An earlier study found THCP, as well as CBDP, which are larger forms of THC and CBD, respectively. Now, the same team of researchers from Italy bridged a gap between regular CBD and CBDP. They found a unique form of THC as well as CBDH, a new cannabinoid for pain.
The size of the cannabinoid depends, mostly, on the number of carbon atoms. Regular THC and CBD have side chains that consist of five carbon atoms, and the ‘phorol‘ cannabinoids contain seven. Whereas, CBDH (cannabidihexol) is a hexyl cannabinoid with a six-carbon sidechain. (1)
NEW THC FOUND WITHOUT LUCK
Adding to the discovery, the team also found THCH (Δ9– tetrahydrocannabihexol). However, the quantity they collected was insufficient for further tests. It is still unknown if THCH is an intoxicant; potent like THC or even THCP. In any case, the new variants came as no surprise considering a cannabinoid that resembles THCH was synthesized in 1949. This artificial substance, known as parahexyl, is psychoactive and similar in structure to THCH. So, the researchers decided to check. They had to make sure they were looking at new natural analogs of THC and CBD, not some previously known methylated groups.
The Regional European Development Fund financed the research project in Florence, Italy. The team studied a strain known as CIN-RO, which was bred by the Council for Agricultural Research and Economics (CREA) in Rovigo, Italy. And like all cannabis approved for research in the boot-shaped nation, the Italian Military cultivated and provided the cannabis.
Stabilimento Chimico Farmaceutico Militare
CBDH OR BUST
When the team isolated CBDH, on the other hand, they collected enough to study its effects on mice. Interest that the researchers took in CBDH in this study contrasted the team’s research on phorol cannabinoids (THCP) one year prior. The earlier scientific discovery disregarded CBDP for its lack of cannabinoid receptor activity. But, regular CBD, with a five-carbon chain, lacks true activity at the cannabinoid receptor and instead has an allosteric relationship that took decades for man to truly appreciate. Now, the market is flooded and stocks have gone to mushrooms.
ORIGINS OF AN ANALGESIC CANNABINOID
Thankfully, without enough THCH on hand, the researchers took interest in CBDH and the new cannabinoid’s effect on pain. CBDH produced strong antinociceptive (painkilling) properties in mice at an (intraperitoneal) dose of one and two milligrams per kilogram. Interestingly, that effect was void at a higher dose of five milligrams per kilogram. The low dose is on par with regular CBD, but CBDH has atypical effects at larger doses which suggests a biphasic effect.
The team hypothesized the presence of CBGH as a logical origin of other hexyl-cannabinoids. This is because CBG is the origin of both, THC and CBD, much like CBGV which becomes CDBV or THCV. After much analysis, however, they did not find CBGH or any related cannabinoid. In the end, they could not determine how the hexyl cannabinoids, THCH and CBDH, formed in the plant. Clearly, science requires more research to truly understand new variants of THC and CBD found in analytical success stories.
CBDH exhibits pain-relieving qualities (much like its CBD counterpart)
This is the most interesting part of the study. When the Italian researchers identified CBDP a year ago, they found it had very little affinity with cannabinoid receptors and didn’t activate them the same way THCP did.
The same cannot be said for CBDH — not even in the slightest.
Researchers were able to obtain a sufficient sample of CBDH and analyze its pharmacological effects in mice test subjects. They found lower doses were more effective for pain relief and pain management. 1.2 mg/kg of CBDH reduced pain response and 2 mg/kg of CBDH significantly blocked the physiological detection of pain.
Interestingly, higher doses (3 and 5 mg/kg) had no pain-relieving effects, which isn’t wholly uncommon. High doses of certain cannabinoids don’t necessarily equate to more effective. Low and medium doses of, say, THC can be more effective than higher doses for certain ailments.
What the researchers say about CBDH’s pain-relieving properties
The researchers believe CBDH’s pain-relief and pain-management qualities could be the result of vanilloid receptor activation (TRPV1), which helps mediate pain, pain-perception, and body temperature. In higher doses, however, they believe CBDH may block CB1 and CB2 receptors involved in the body’s response to pain, causing no pain-relief at all.
How does this differ from CBD?
CBD isn’t known for having the greatest relationship with your endocannabinoid system. Doesn’t bind to either cannabinoid 1 or cannabinoid 2 receptors. In fact, it barely even touches them (not directly at least). CBD has more of an affinity with other receptor sites e.g. serotonin (5-HT) receptors and the aforementioned vanilloid (TRPV1) receptors.
CBD’s targeting of serotonin and vanilloid receptors produces different effects and benefits from each other. Serotonin activation produces anti-depressant and anti-anxiety effects in rodent test subjects, whereas vanilloid activation results in the mediation of pain-perception, inflammation, and body temperature.
Because CBDH’s molecular structure is almost similar to CBD’s (CBDH has a six-alkyl side chain, while CBD has a five-alkyl side chain), it’s not unreasonable to assume they act in a similar way.
How CBDH could be used
To be perfectly honest, we can only surmise CBDH’s real-world uses based on one study.
If CBDH is a powerful pain-reliever in mice test subjects, there’s scope to suggest low-to-moderate isolated doses, alongside other analgesic cannabinoids such as CBD, CBG, and THC could be used in clinical treatment in the future.
This isn’t for certain, though. So much more needs to be looked at before we can accurately evaluate its uses beyond limited preclinical animal studies. We look forward to seeing how this exciting cannabinoid develops in the future.
Key Points:
In low doses (1.2–2 mg/kg), CBDH reduced pain in mice test subjects. In higher doses (2–5 mg/kg), there was no pain-relieving effect.
CBDH’s pain-relief qualities might be the results of vanilloid receptor activation — vanilloid receptors mediate pain and pain management.
Real-world use of CBDH is still unknown but could be used as a potent pain-relief cannabinoid.
Researchers were unable to sufficiently test THCH’s effects
It’s always super exciting to read about a new THC variant. THC itself is a phenomenal cannabinoid responsible for a whole heap of amazing benefits such as pain relief, neuroprotection, sleep problems, antibacterial, and antiinflammation. Its variants (delta-8-THC, THCV, etc) are also incredibly useful to you.
Unfortunately, researchers were unable to extract enough THCH to sufficiently evaluate how it interacts with rodents. It’s unknown whether THCH is intoxicating or has unique benefits similar (or separate) from THC and its other variants.
However, a near-identical synthetic homolog of THC was inadvertently created in 1949 after scientists attempted to understand THC’s effects. This homolog, known as parahexyl (n-hexyl-Δ3-THC), is intoxicating, presumably binding tightly to CB1 receptors. Used as an anti-anxiety treatment in the 20th century but later banned and placed as a Schedule I controlled substance.
Does THCH cause these effects and benefits? Maybe. But we’ll only know when more research is carried out.
There are currently no CBDH or THCH-centered products on the market
Over the past couple of years, cannabis brands and manufacturers have sight their sights on other cannabinoids away from CBD and THC. High percentages of isolated minor cannabinoids such as CBG, CBN, and CBC can now be found in several products across the US.
Right now, CBDH and THCH are naturally found in regular cannabis products but not in high percentages.
It might be a while before we see CBDH or THCH isolated into a product but we’re more than excited to see it!
Or will CBDH become tomorrow’s wash of marketing gimmicks?
SOURCES
Linciano, P., Citti, C., Russo, F. et al. Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol. Sci Rep10, 22019 (2020). doi/10.1038/s41598-020-79042-2
Morano, A., Fanella, M., Albini, M., Cifelli, P., Palma, E., Giallonardo, A. T., & Di Bonaventura, C. (2020). Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects. Neuropsychiatric disease and treatment, 16, 381–396. https://doi.org/10.2147/NDT.S203782
We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology. We are often faced with our own personal conflicts which directly influence our interactions with our peers and family.
When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.
1st Hemp USA News is a resource of Inspirational Technologies (2021-2023)Inspirational Technologies (2023) AllRightsReservedYour ONE STOP BLOG FOR INFORMATION, EDUCATION, & INSPIRATION OF ESSENTIAL INNOVATION & RENOVATION of You-THANK YOU FOR YOUR INTEREST*This site receives virtually no compensation for sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research, development, discovery and healing.Inspirational Technologies – is Committed to Your Health Wellness Beauty and EnrichmentReporting on Today’s Internal Botanical and Skin Product Benefits
4 Hemp Club was Inspired by Steven Smith’s vision to “Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.
Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the
4 Hemp key points being Health Hope and Happiness, thru Hemp“.
Cannabis CBD and Me Inspirational Technologies Inspirational Technologies (2014) @Inspire123tech Background Noise Studios Logos bySteven M Smith
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