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What Cannabis Can (and Can’t) do for Chronic Pain. Pot for Pain Relief?

What Cannabis Can (and Can’t) do for Chronic Pain. Pot for Pain Relief?

(Story by Karen Weintraub, USA TODAY) reprinted 1/26/2023. 
A growing, but still incomplete body of research suggests the cannabis plant, the source of marijuana, can help fight some kinds of pain.

Rob Sims grew up hearing stories about what opioid addiction could do. The former Detroit Lions guard, whose father, Mickey, also played in the NFL, watched a number of his dad’s friends get hooked. Some died. He vowed his own story would be different.

Then, playing for the Seattle Seahawks in 2008, early in his pro football career, Sims tore a pectoralis muscle in his chest. Primed for his best year ever, Sims was sidelined.

After surgery, he received an open-ended prescription for opioids. “Take when you have pain,” the bottle read. “That’s seared in my memory,” he said. As a football player, “I have pain all the time.”

Scared by the lesson he had learned as a child and with little to do besides focus on his recovery, he remembers thinking: “This could go in a bad way.”

That’s when he turned to marijuana.

It remains unclear whether cannabis can be an effective treatment for pain. Plenty of circumstantial evidence supports the idea, but exactly how, what kinds of products and what can be expected from them has yet to be determined.

“There’s some caveats before it’s ready for broad, prime-time usage for chronic pain,” said Dr. Devan Kansagara, a professor of medicine at Oregon Health & Science University and a staff physician at the VA Portland.

It’s possible that cannabis helps with the psychological aspects of pain, said Dr. Nora Volkow, head of the National Institute on Drug Abuse. “Cannabis may improve pain indirectly, for instance, through decreasing anxiety so that someone may be able to deal with pain better,” she said.

Rob Sims was a guard with the Detroit Lions and now runs a cannabis business with fellow former Lion Calvin Johnson Jr., right. © Carlos Osorio, AP

Detroit Lions guard Rob Sims during the game against the Green Bay Packers at Lambeau Field, Dec 9, 2012.© Benny Sieu, USA TODAY Sports

One recent examination of previous studies found the benefits of cannabis were equal to the benefits of a placebo, which means that if people thought it would help, it did.

“There’s very limited evidence out there to support that cannabis is effective against pain,” said Karin Jensen, the Swedish neuroscientist who led the study. So far, most of the information showing its usefulness is anecdotal.

“People who use cannabis to relieve pain may have the experience that it helps – there is no doubt about that,” she said. “What’s needed is solid scientific evidence to determine how much of the relief is due to the cannabis and how much is due to other things, such as the placebo effect.”

The general public is already largely convinced.

Marijuana remains illegal in 12 states, but as of 2019, 18% of U.S. adults reported using cannabis at least once in the previous year, and 4% to 5% use it daily or nearly daily, Kansagara said.

In a 2017 study, the majority of people who used medical marijuana or self-medicated with the drug said they did so to relieve pain, and 65% of those who requested medical marijuana licenses said they wanted it to treat pain.

The marijuana plant provides a wide range of chemicals, including THC, which has psychotropic effects/

But cannabis comes with cautions.

At least 5% of Americans ages 12 and up abuse or are dependent on marijuana, and the risk for dependence increases the younger someone starts. Marijuana use directly affects parts of the brain responsible for memory, learning, attention, decision-making, coordination, emotion and reaction time. And long-term or frequent marijuana use, particularly at higher doses, has been linked to increased risk of psychosis or schizophrenia.

It’s not possible to predict ahead of time who will react badly to marijuana, said Dr. Charles Berde, co-founder of a pediatric pain clinic at Boston Children’s Hospital.

THC, the part of the plant that has psychotropic effects, “has narrow uses for nausea and appetite stimulation in patients with severe weight loss due to AIDS or cancer,” but the data for CBD for treatment of chronic pain is “murky,” Berde said. “All the more reason to be hesitant to prescribe it.”

Cannabis and pain relief

When a body is in pain, the brain releases its own pain relievers. There are special receptors in the brain designed to take in these natural cannabinoids and offer relief.

Ingesting or inhaling weed fills up those receptors, too.

Providing more cannabinoids than these receptors can accept overloads them making the person’s own internal cannabinoids ineffective, said Dr. Jordan Tishler, a cannabis specialist physician in Cambridge, Massachusetts, and founder and president of the Association of Cannabinoid Specialists.

That’s why higher doses don’t provide any additional pain relief compared with lower ones and can have “all sorts of risks,” he said. Side effects from cannabis can include increased heart rate, dizziness, impaired concentration and memory, slower reaction times and, more rarely, increased risk of heart attack and stroke and dependence.

Tishler said many patients come to him taking far too much cannabis, which increases the risk for side effects. He works to convince them that 5 mg to 20 mg a day will treat their pain better than the 200 mg they’re using.

Cannabis is now sold in many different forms.

“Just because (cannabis) doesn’t lead to breaking the law and incarceration and those sorts of troubles doesn’t mean people can’t have their lives significantly altered by getting overly involved with this particular substance,” he said.

There are also open questions about cannabis, including whether the pain-killing benefits seen in short-term studies will last. Some painkillers, like opioids, can actually make people more sensitive to pain. It’s not yet clear whether cannabis can have this effect.

“You’d like to see what happens with these products over a longer period of time, ideally,” Kansagara said. “I would like to see that before recommending wholesale to patients.”

Although legalization and decriminalization are making a difference, cannabis remains hard to study. Until recent years, it was extremely difficult to gain access to cannabis for research, and there was little federal funding for such work. In early December, President Joe Biden signed a law that will make it easier to research cannabis.

Dr. Donald Abrams, speaking in support of the Adult Use of Marijuana Act ballot measure in San Francisco on May 4, 2016. © Jeff Chiu, AP

Gold-standard studies compare a treatment versus a placebo, but it’s impossible to keep people in the dark about whether they’re getting high, said Dr. Donald Abrams, an oncologist and professor emeritus at University of California, San Francisco, who studies cannabis.

When Abrams studied cannabis use in his HIV patients, some critics thought patients must be too stoned to notice their pain. But Abrams said the patients reported that it did alleviate their pain.

Dosages of cannabis aren’t standardized, which adds to the difficulty of comparing one study against another, he said.

That’s why trials of cannabis for pain relief have shown mixed results, said Wil Ngwa, an associate professor of radiation oncology at Johns Hopkins Medicine, who’s working to create such standards for drug trials.

This lack of standardization also means people have to use trial and error to find an effective dose for them, according to Staci Gruber, who directs the Marijuana Investigations for Neuroscientific Discovery (MIND) program at McLean Hospital, a Harvard-affiliated psychiatric hospital outside Boston.

In one study, Gruber followed 37 volunteers using cannabis for chronic pain. After six months of treatment, participants reported lower levels of pain, better sleep, more coherence and less use of conventional painkillers.

‘Positives, not negatives’

Sims experienced the same benefits.

Daily marijuana use after his pec injury helped cut the pain, allowing him to lift more weight and recover faster. “I was able to come back stronger than I was before.”

Playing NFL ball, Sims said, is like living through a train wreck every Sunday. The best players – the ones whose careers last the longest, he said – “have learned how to recover quicker and get ready for that next train wreck.”

During his career, marijuana helped Sims rebound and improved his sleep, which allowed him to push his workouts.

Asked about side effects from his marijuana use, Sims pointed to his athletic and financial successes. “I wouldn’t call those side effects,” he said, laughing. “I see positives, not negatives.”

In 2021, Sims co-founded the cannabis company Primitiv Group with fellow former Lion Calvin Johnson Jr. Sims and Johnson acknowledge they used cannabis during their professional careers, though there was a zero tolerance policy then, which has loosened only slightly since. Both men believe the restrictions should be lifted.

About a decade ago, Sims persuaded his wife, Natalie, to try cannabis, when a bout with the bowel syndrome Crohn’s disease left her on a morphine drip in an emergency room.

“This can’t be how we live for the rest of our lives,” he told her. She uses cannabis now and finds relief, Sims said.

“It made me very passionate about pain and help for pain.”

Challenges of cannabis care

Cannabis doesn’t make pain go away, like Advil might get rid of a headache, Tishler said.

Instead, “it makes it so it doesn’t bother you so much,” he said. “It divorces the pain from the suffering.”

Whether it’s the THC or the CBD in cannabis or both that might be helpful against pain remains an open question, Kansagara said. THC is what makes people feel “high.” CBD appears to have anti-inflammatory properties, which may be useful to some.

Smoking joints isn’t a good approach for relieving chronic pain, said Tishler, who recommends his patients use edibles instead. The effect of inhaled cannabis wears off in three to four hours, while a gummy might last eight to 12 hours.

The yo-yo effect, when pain comes and goes over a few hours, can exacerbate suffering, Tishler said. “Short-acting actually turns out to be a bad approach in general in pain management.”

In Massachusetts, where medical cannabis has been legal since 2013 and recreational since 2016, doctors are more comfortable giving their patients permission to use cannabis, Tishler said. But they rarely bring it up themselves.

So, Tishler is trying to educate his peers. “If you were thinking the patient needs opioids, think cannabis first. Don’t wait for the patient to bring it up – it’s your job to bring it up,” he tells them.

Similarly, he’d like to get cancer patients on cannabis early in their care, rather than waiting until agony sets in. “Once people are at the end of their rope, things are worse and harder to treat than if we had started when things were still kind of OK.”

Most of the advice on what product to use now comes from the patient care advocates or “budtenders” who work behind the counter at dispensaries, Gruber noted with some concern. They typically don’t know the person’s medical history or history of cannabis use or whether they use other substances such as alcohol, other drugs or prescription medication. Product labels can often be misleading about their THC and CBD content.

The trial-and-error approach can be difficult and challenging for patients with major medical problems.

“Knowing what’s in your weed is critical, but also how you’re going to respond to it is an important consideration. And that’s something we don’t spend a lot of time on,” Gruber said. “You have to educate patients. They’re desperate for it, but it’s not easy, because we’re all different and cannabis is not a ‘one size fits all’ solution.”

Research may change future use.

For cannabis to reach its full potential as a painkiller, more research is needed, experts say.

“It’s really untapped right now, because of that lack of research,” Johnson said.

That’s why NFL players and owners have been supporting cannabis research. Owners have donated more than $1 million this year to two cannabis research programs.

“We need to become better educated about all these issues,” said Dr. Allen Sills, the NFL’s chief medical officer.

Dr. Allen Sills, the NFL’s chief medical officer© Rebecca Blackwell, AP

Ngwa, at Hopkins, collaborates with Sims and Johnson to lead some of that research.

He’s also looking at better ways to treat cancer pain with cannabis.

His studies suggest that not enough of the painkiller gets to a tumor when the cannabis is inhaled or ingested, so he has been exploring smart-drug delivery systems than can target the drug directly to the tumor. So far, he has tested only pancreatic tumors but hopes to rapidly expand to other cancer types.

Ngwa is concerned that preliminary research like his will encourage people to self-medicate, taking doses that may not be helpful. “You really have to wait for the clinical trials, but when people are desperate, they just do (anything). I definitely worry about that,” he said.

Until more is known, Sims will keep up his cannabis routine.

Now 39, he has dropped 50 pounds from his 320-pound playing weight, which has helped reduce the lingering bone-on-bone pain in his right knee. He rubs a Primitiv topical on it knee every day.

“My passion behind the plant and what it’s done for my family reigns supreme.”

Contact Karen Weintraub at kweintraub@usatoday.com.

Health and patient safety coverage at USA TODAY is made possible in part by a grant from the Masimo Foundation for Ethics, Innovation and Competition in Healthcare. The Masimo Foundation does not provide editorial input.

Consuming medicinal cannabis oil improves sleep in adults with insomnia

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Happy New Year! CBD FIRST THING – Time to Get Going NOW in 2023

As 2022 has now past us by, although, not as soon as some had wished. It is now time to assess 2023.

You may be considering the questions no one in this New Year may be asking.

Embarking on new regimens, such as new embraces.

In the world old of CBD, AS IF, IT HAS become, as COMPLICATED In YOUR LIFE, as it has become in mine. You Have to Zero in on what is right for your condition. And this takes time and patience. We have found that as you zero in on the right CBD for you, you’ll no doubt run through a list of considerations, including potency, flavor, price, and type (oil, topical, gummy, etc.). But once you’ve decided on all of that, there’s another factor to think about-

 

There are a few tried and true guidelines for when to take your CBD. What you choose will depend on your particular lifestyle and the reasons you’re taking CBD in the first place, but these suggestions might be helpful in your exploration of the optimal schedule.

CBD FIRST THING

Mornings tend to follow a routine of sorts that can prepare us for the day ahead. From those first few moments of waking up, to warm showers and some kind of breakfast, we get ourselves ready to face whatever’s on the docket. Taking CBD first thing ensures that it’s checked off the list and you won’t have to remember it later. You can keep your CBD 

next to your bed or in the kitchen so you don’t have to worry about bringing it with you to work or out on your errands.

Another perk of taking CBD in the morning, especially before breakfast, is that your stomach is empty. This means that if you’re taking any form of ingestible CBD, those cannabinoids will have front-and-center attention in your body without any other distractions in the digestive system. Another advantage of taking CBD in the morning is that for many of us, those morning hours set the tone for the rest of the day. So rather than pushing through early on, many people prioritize feeling their best during those beginning hours so that they can more easily tackle whatever comes next.

WIND DOWN WITH CBD

There are two sides to every coin, and while mornings may be a priority for some, nighttime is just as often the target time for those who suffer from sleep issues or difficulty winding down after a busy day. When the hubbub of activity starts to die down and yet you’re still feeling frenetic inside, or your aches and pains start to really flare after a long day, then taking CBD in the evening might be good for you. It’s still suggested to try to take any ingestible CBD on a relatively empty stomach, so avoid taking with meals if possible.

 

If sleep support is what you’re after, you might want to try taking your CBD oil 30-45 minutes before bed. It will help if you also transition into lower light, detach yourself from electronic devices/screens, and get comfortable so that you’re truly ready for bed. If you’re taking gummies, then you might try taking them about an hour before bed, as it takes a bit longer for the body to engage with CBD through the digestive system.

THE AS-NEEDED APPROACH

Here’s one of the amazing things about CBD– it’s not something that you can easily overdose on, and the side effects of taking way too much are relatively benign. This is why there are serving suggestions on many CBD products, but in many usage guidelines you’ll see the option to take “as needed.” Often, people will take CBD oil in the morning or evening and carry their CBD gummies or cream around with them throughout the day to use as the need arises. People often ask if it’s ok to take multiple forms of CBD in the same day and the answer is yes.

Are you looking to get the most out of your CBD and want to know how much to take? With cannabidiol now legal in many states, many people are learning about its therapeutic benefits and want to know how they can benefit from them.

Whether you’re curious about CBD and want to try it out, or are already a regular user, you may find yourself wondering about what level of dosage is right for you. As with any kind of substance we consume—holistic, natural, pharmaceutical, or otherwise—CBD should be measured and researched before use. That’s why we created this CBD dosage chart to help you decide.

Why Dosage Matters

Why does CBD dosage matter? Well it matters because everybody and every body is different! As with many things in life, you need to approach slowly and learn about your body’s threshold. Some people drink one cup of coffee and feel refreshed, whereas others may need several cups to feel fully awake, and others still may take one sip and feel unpleasantly jittery for the whole day.

The same principle applies to CBD dosage, so if you’re a newbie remember to start low and go slow. It is generally recommended to start with 5-10mg of CBD per day over a week, and then slowly increase if needed.

Here are some of the considerations that go into determining dosage:

  • Weight: A higher body weight will generally mean a higher amount of CBD is needed in order to feel the desired therapeutic effects. The same principle applies inversely for a lower body weight: generally a smaller dose is effective.
  • Ailment and severity: Depending on what ailment you’re looking to soothe, and how intense the discomfort or pain it is, dosage will vary.
  • CBD Tolerance: Your personal receptiveness to CBD is determined by your endocannabinoid receptors. This factor varies person to person. Think of it as similar to how certain people have a higher or lower tolerance to drinking alcohol.
  • CBD product type and bioavailability: Your dosage will vary based on what method you are using to consume it, as well as how much cannabinoids are in the product itself. Reputable sellers will include information about the level of cannabinoids in the product, whether it’s a gummy, oil, tincture, vape cartridge, or loose bud. Oil and edibles are consumed orally, meaning they go through your digestive system and take effect slowly. When you smoke or vaporize, CBD enters the bloodstream through the lungs and the effects are felt more quickly. Us

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

You also don’t necessarily have to take CBD every day! One huge advantage to the as-needed approach is that you’ll only be taking it when you feel it’s really necessary, so you likely won’t build up a tolerance which might then require higher dosage. While chronic pain sufferers may be better served by regular use, if you’re really only using CBD for the occasional ache or pain, then you can let your body choose for you!

While it’s suggested that you take CBD regularly when you first start, that’s mostly so that you can learn how your body reacts and you can zero in on the best dosage for you. That is most easily discovered when you’re consistent and give the body a chance to learn more about CBD. Once you’re clear on the best dosage for your body, feel free to take it on whatever schedule (or non-schedule) works best for you!

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What is CO2 Extraction? What Hemp and Marijuana Growers Need to Know.

 

 

What is CO2 Extraction? The Supercritical CO2 extraction process creates phase changes in carbon dioxide utilizing temperature and pressure.

CO2 is known as a “tunable solvent” making it extremely versatile for creating a multitude of end products by controlling temperature and pressure.

These phase changes create an environment to drop out differing weights of components in the plant material.

The unique design of the Hi-Flo™ Series systems allow for separation and collection of these constituents during a single extraction.

This enables collection of light essential oils separately from other desirable constituents and heavier lipids.

Supercritical CO2 fluid extraction (SCFE) methodology delivers a clean, unaltered, consistent-yet-flexible product.

Removable Molecular Components is a Positive Clean Alternative for CBD Extraction

CO2: Clean, Safe, Quick CO2 Extraction is good business.

It allows you to create a pure, clean, quality oil that is safe to produce with little-to-no post-processing.

Processes that use toxic solvents may require many hours to purge the solvent trapped in the oil.

Multiple industries have proven that the highest efficiencies in commercial processing utilize CO2. CO2 offers you the ability to “tune” the extraction process, especially with a system that will separate constituents during an extraction.

You can target specific compounds, like terpenes (terpenoids) and THC/CBD (cannabinoids) through different operational parameters.

CO2 is also a sanitizing agent, prolonging shelf life, and, with t

he proper system and environment, yields food and medical grade oils.

CO2 extraction is a safe, clean, and highly versatile method of extracting plant botanicals, nutraceuticals, hops, and hemp.

For the Originality in Extraction

Supercritical carbon dioxide (sCO2) is the most widely used fluid for the Supercritical Fluid Extraction (SCFE) process across the globe. Not only is sCO2 capable of extracting the required ingredients in their pristine form, the prime reason for the surging popularity of SCFE, it also makes the process more manageable, economical, and safe.

Buffalo Extraction Systems Carbon dioxide (CO2) Supercritical Fluid Extraction (SCFE) Plant

These days, “clean label” products are selling like hot cakes. Increasingly health-conscious customers are placing a premium on natural ingredients in the food, pharmaceutical, beverage, and neutraceutical products they consume. Now, clean label is a broad term with various meanings – organic, natural, locally grown, non-GMO . . . the list goes on. Some even take it to link its maker to more transparent work practices.

Alternative processes such as Solvent Extraction and Hydro distillation leave behind harmful residues. Plus, they distort the ingredient being extracted. That is, the ingredient does not retain its natural purity. Regulations have caught up with public demand and impose exacting conditions to ensure the quality and safety of products by limiting toxic residues. One more reason to rely on CO2 SCFE.

What Makes Supercritical Carbon dioxide (sCO2) an Exceptional SCFE Solvent?

Carbon dioxide and water are the most widely employed supercritical fluids. sCO2 makes such a useful supercritical fluid because:

Although CO2 is a greenhouse gas (GHG), the SCFE process using CO2 becomes eco-friendly if the gas is captured from the atmosphere and recycled.

Carbon dioxide Supercritical Fluid Extraction (CO2 SCFE)

Solvent Extraction employs organic solvents to dissolve the ingredient from the raw material. Later, it separates the organic solvent from the dissolved ingredient. The problem is, organic solvents do not completely disassociate from the ingredient, leaving behind residues.

Parameter Solvent Extraction SCF Extraction
Solvent traces in final product Yes Zero
Heavy metal content in final product Yes Zero
Inorganic salt content in final product Yes Zero
Similarity with the actual components to be extracted in terms of Colour and Flow Characteristics Less: because polar compounds get dissolved. More: because low operating temperatures and selective extraction of CO2.

Table 1. SCFE Vs Solvent Extraction

That is, the ingredient loses its natural purity. What is more, it may develop a certain degree of toxicity. But the concerns on using organic solvents for extraction go beyond toxicity for the individual. Some solvents are ozone depleting substances, and their use negatively impacts the environment.

Hydro distillation i.e., the use of water and steam distillation inherently employs heat, something that thermally degrades the ingredients. Again, the ingredient, when extracted, is no longer available in its pure form.

Parameter Steam Distillation SCF Extraction
Extraction of essential, non-volatile oils Not possible Possible
Extraction of highly volatile oils Not possible Possible
Oxidation and Hydrolysis (undesirable) Possible Not possible
Similarity of essential oils with the extracted component in terms of Form, Aroma, and Physical Characteristics Less More

Table 2. SCFE Vs Steam Distillation

As a process that holds the United States FDA’s “Green Technology” approval, CO2 SCFE enjoys sizable international clout. One reason for its eco-friendly nature is that it does not generate effluents, automatically eliminating pollution control hassles and costs.

Examined in the context of the limitations of hydrodistillation and solvent extraction, CO2 SCFE delivers a much better performance on all fronts during the extraction of:

 

Organopletic properties of wines are their aroma, fruitiness, crispiness, sweetness, and freshness. Hop is the plant whose flower imparts the prized bitter taste to beer.

The selectivity of SCFE is an asset here as it can separate anthocyanin from the pulp of Euterpe oleracea at a certain pressure while extracting phenolic phytochemicals from that very pulp at another pressure.

The Verdict

People the world over are shifting to natural alternatives – natural medicine, natural food, natural beverages – in realization to the long-term side effects that synthetic products, possibly laced with toxic residues, can unleash on health and overall wellbeing.

Effectively this means, the SCFE process and, more specifically, the CO2 SCFE process, are here to stay . . . for ages.

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the idea behind the banking legislation is not to make pot legal but to allow businesses that represent the legal cannabis market to use banks, instead of having cash everywhere

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MJBizCon Kicks off in Las Vegas amid economic turmoil, hopes of Marijuana reform

MJBizCon kicks off in Las Vegas amid economic turmoil, hopes of marijuana reform

Be at the forefront of the latest cannabis scientific research. Submit a research abstract to present by Dec. 16 or register to attend the The Emerald Conference by MJBizScience, March 1-3 in San Diego.

 


MJBizCon attendees pick up their badges Tuesday for the 11th edition of the nation’s largest cannabis industry conference. (Photo by Alicia Fresquez)

MJBizCon, the oldest and largest trade show in the cannabis industry, officially opens Wednesday amid growing economic challenges and renewed hope that federal marijuana reform will help the industry in the wake of this month’s midterm elections.

Now in its 11th year, MJBizCon runs through Friday and features more than 1,400 exhibitors, 70-plus hours of educational content and 180 speakers.

More than 380 exhibiting companies are new to the showcase this year.

The expo hall, the largest in MJBizCon history, spans nearly 280,000 square feet on two floors of the Las Vegas Convention Center’s South Hall.

It’s where tens of thousands of cannabis industry professionals will convene for networking, startup funding, strategic partnerships, insights on regulatory reform and the political landscape and other topics.

This year’s event arrives amid another critical juncture for the industry.

Cannabis companies, like others in mainstream sectors, are laying off workers and implementing other cost-cutting measures as prices for wholesale marijuana fall and recessionary concerns rise.

Meanwhile, the Biden administration has set in motion a process that could lead to revolutionary changes for federal marijuana policy.

The midterm elections, which often highlight the nation’s political polarities, provided a mixed bag of results on the marijuana front.

Among the many changes this year at MJBizCon, a new design divides the exhibition floor space into four distinct pavilions to help attendees find what they need:

  • Cultivation products and services.
  • Processing, packaging and lab services.
  • Retail and dispensary.
  • Business services.

“We can’t wait for everyone to see what’s new at MJBizCon – new exhibitors, a reorganized show floor, an outdoor patio,” said Jess Tyler, MJBiz’s senior vice president for events and sales.

“We really upped the experience this year.”

In a Wednesday highlight,

MJBiz CEO Chris Walsh

delivered his “State of the Industry and Predictions for 2023” in which he outlines the cannabis business environment and opportunities for future growth.

Other topics featured at the conference will include the recent elections, mature and emerging market difficulties and opportunities, strategies to overcome current headwinds and whether federal reform, particularly the passage of SAFE Banking Plus, is gaining momentum.

The main stage on Wednesday will feature in-depth discussions with cannabis industry leaders and successful mainstream executives.

Highlights include:

  • A fireside chat with Cookies co-founder and CEO Berner, an expert on branding and global expansion in the cannabis industry. The rapper, who recently sat down with MJBizDaily for a Q&A, will discuss how he and his brand have become influential.
  • Insights from Rhonda Kallman, a trailblazer in the alcoholic beverage industry with decades of business, branding and marketing expertise. Kallman, who was recently the subject of an MJBizDaily Q&A, founded the Boston Beer Co., producer of Sam Adams, and now runs Boston Harbor Distillery.
  • A “power panel” of cannabis business leaders including Wana Brands co-founder and CEO Nancy Whiteman; Ruben Lindo, founder of Blak Mar Farms; The Parent Co. CEO Troy Datcher; Toi Hutchison, president and CEO of Marijuana Policy Project; and Acreage Holdings CEO Peter Caldini.

Additional experiential exhibits include the return of the Hall of Flowers Experience at MJBizCon, First-Timers Open House, Innovations Product Showcase and the Exhibitor Spotlight Theater.

MJBizCon has also partnered with CannaVest to host the CannaVest Institutional Investment Conference for institutional and accredited industry investors.

Other notable breakout sessions off the main stage include:

MJBizCon also features a new scholarship program, pop-ups from Women Grow and Black Cannabis Magazine

, and networking events focused on women and Black entrepreneurs as well as other people of color. The MJBiz app and signage help attendees find women- and BIPOC-owned businesses on the expo floor.

Attendees can convene at one of two lounges, The Joint (first floor) and Elevation (second floor), to hydrate, plug in or meet up.

They can also visit The Patio at MJBizCon, a newly added outdoor gathering space to unwind, get fresh air or check out some cool experiences, including a 360 photo booth, yard games, DJs, drink options and food trucks.

The conference has a soft kickoff Tuesday with six preshow forums at the Westgate Las Vegas hotel, next to the Convention Center:

  • MJBizFinance Forum.
  • MJBiz Hemp + CBD Forum.
  • MJBiz Marketing Forum.
  • MJBizScience Symposium.
  • reMind Psychedelics Business Forum.
  • Associations Day.

More information, including registration details, speakers and session topics, is available here. Online registration remains open all week.

Chris Casacchia can be reached at chris.casacchia@mjbizdaily.com.

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Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the

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DEA Announces How Much Marijuana, MDMA, Psilocyn, LSD, Mescaline, 5-MeO-DMT, MDA, 2-CB Can Be Produced For Research In 2023

DEA Announces How Much Marijuana, MDMA, Psilocyn, LSD, Mescaline, 5-MeO-DMT, MDA, 2-CB Can Be Produced For Research In 2023

Story by Lara Goldstein 

The DEA has shared its final production quotas for research drugs for 2023 and is now aiming for further manufacturing goals of several psychedelic compounds than the already substantial increases regarding 2022 initially proposed, reported Marijuana Moment.

DEA Announces How Much Marijuana, MDMA, Psilocyn, LSD, Mescaline, 5-MeO-DMT, MDA, 2-CB Can Be Produced For Research In 2023© Provided by Benzinga

The compounds include marijuana, MDMA, psilocyn, LSD, mescaline, 5-MeO-DMT, MDA, and 2-CB.

The agency stated that it is “committed to ensuring an adequate and uninterrupted supply of controlled substances in order to meet the estimated legitimate medical, scientific, research, and industrial needs of the U.S., for lawful export requirements, and for the establishment and maintenance of reserve stocks.”

As such, 2023’s production quota numbers for psilocyn would go from the original 8,000 grams to 12,000 grams, 5-MeO-DMT from 6,000 to 11,000, MDMA from 8,200 to 12,000 grams, MDA from 200 to 12,000 grams, and 2-CB from 25 to 5,100 grams.

Related video: Recent data shows a decline in marijuana sales (CBS Denver)

 

In the case of marijuana, the DEA suggested the production of 6.7 million grams -or 14,770 pounds- for medical and scientific purposes, more than double that of 2022. Licensed cultivators can now apply to become federal marijuana suppliers under the National Institute on Drug Abuse (NIDA.)

Several companies have already made recommendations to raise DEA’s 2023 proposed quotas in view of pre-clinical and clinical research particularly for PTSD, TRD, schizophrenia and anxiety.

The proposal also received a comment regarding the creation of “diversified categories” for production and research on psilocybin-containing fungi fruiting bodies/sclerotia/liquid culture similar to cannabis (flower), fruiting body extract (akin to cannabis extract), and psilocybin and psilocyn separately as purified compounds (akin to delta-9-THC), as well as applying that same system for mescaline and other plants, fungi and lifeforms producing these compounds.

But the agency replied stating that the suggestions “do not impact the analysis involved in establishing” the production quotas for each substance.

Nonetheless, the DEA seems to be listening to what is taking place in the psychedelics space, as it has recently backed down on banning two psychedelic compounds claimed to have scientific value as well as a separate project to list five tryptamines as Schedule I substances.

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4 Hemp Club was Inspired by Steven Smith’s vision to

“Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.

Our 4H Platform Uses HEMP as an Agricultural Focal Point, deserving of research, development and with the

4 Hemp key points being Health Hope and Happiness, thru Hemp“.

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New York has $750 Million Worth of Cannabis that Growers cannot yet Sell.

New York has $750m worth of Cannabis Stockpiled that Growers can’t Sell. Word to Those States Leaning Legal.

Story by E Helmore, 
New York, NY   November 19, 2022 
Cannabis farmers have ‘an unclear path to market’ as the state has yet to approve retail dispensaries.

A strong smell of weed hangs over many New York neighborhoods, the result in part of cannabis decriminalization in 2019 – but cannabis growers in the state are at an impasse when it comes to getting their crops to market.

Photograph: Mary Altaffer/AP© Provided by The Guardian

Almost 300,000 pounds of the drug, worth as much as $750 Million, from last summer’s production at 200 state-licensed farms are stockpiled, without a place to be sold and in danger of deteriorating, according to a report said on Saturday.

Distribution issues are to blame. Although the New York City has vape shops selling marijuana and CBD products on almost every street, and there are mobile weed vans on Times Square, New York’s office of cannabis management , has just approved regulations regarding retail sales/after Legislation signed back in March 2021.   WORD TO NEW STATE LEGISLATION. BE A PATIENT BUT BE PATIENT.

New York regulators have approved the first round of retail licenses that will kick off the legal adult-use cannabis market in the state.

The Office of Cannabis Management (OCM)

TAKING BOLD ACTIONS TO ENCOURAGE SOCIAL JUSTICE, PUBLIC HEALTH AND ECONOMIC DEVELOPMENT IN THE LIVES OF ALL NEW YORKERS
Office of Cannabis Management

The Marijuana Regulation and Taxation Act creates a first in the nation comprehensive regulatory structure to oversee the licensure, cultivation, production, distribution, sale and taxation of medical, adult-use and cannabinoid hemp within New York State.

Approved the applications of 36 individual businesses and nonprofit organizations that have been granted conditional licenses to open up the first dispensaries in New York.  But several issues may delay the full implementation of cannabis legislation in the state.

The OCM announced the first round of conditional licenses for 28 individuals and eight nonprofit organizations yesterday.

 

Not one legal recreational dispensary has opened. Last week, a federal judge handed down an injunction that blocked the state from handing out licenses in Brooklyn and areas of the Hudson Valley region after a lawsuit claimed that the state’s cannabis equity program violates the US constitution.

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“Have an older generation 4H Club, where an older community of adults could carry on what the younger 4H Club envisioned.

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