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A Quick Guide to the Psychedelic Mushroom Boom

The majority of the psychedelics community has rarely made contact with the world of venture capital and high-growth startups.

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This is dangerous because it doesn’t allow for those that work with psychedelic substances to understand what the next 10 years will bring their way… and as of right now the future doesn’t look too bright.

A Venture Capital (VC) firm, is in its simplest form just an entity that invests the money of rich folks into the companies that it believes will become the most financially valuable. There are of course other considerations for some investing groups such as: patient outcomes, environmental impact and sustainability, and general ESG methodologies. But for the most part VC firms work to provide a , financial gain,to their investors by providing cash to startups that want to grow their business fast.

Let’s say that you are a psychotherapist who’s been running their own clinic for a few years. You were trained by MAPS to do psychedelic assisted therapy and have incorporated the service into your practice. Business is booming. Everyone wants access to your transformative care.

Perhaps you want to open up a second clinic where you can hire on some more therapists with the proper training, but you don’t have the money saved up yet to open up another location.

You could wait a few years, go to a bank to get a loan, or you could seek out an investment.

If you choose to go raise money for your venture you’ll be met with a lot of questions most of which will be pointed at one thing: scale. Most investors won’t put down capital for you to just open up one additional clinic. You’ll need to describe a vision of growing fast and scaling your brand to be the most impactful, widely distributed clinic on the planet.

Why? Because investors lose money on most investments that they make. Almost all of their returns are made from the few investments that knock it out of the park. The billion dollar unicorn that can grow their money more than 100x.

None of this is to say that good companies that can generate a high return don’t exist, but it’s very difficult to find that balance. Within our current system, companies need to compete with one another. That competition plays out through cutting costs, moving quickly, and oftentimes deprioritizing people, the environment, and quality.

It’s also very difficult to prioritize long term results. Every VC firm collects a new pool of money every few years called a . Most funds only run for 7 years, 10 years on the long end. Within 10 years you need to see a company sold off or going public for you to cash out and see the fruits of your investment. A company that has a 25 year mission to revolutionize patient care, but has to suffer losses for the first 10? Not going to happen.

As I mentioned earlier, there are strategies for forming firms around values, impact, and longer term results. But it’s extremely difficult. A firm can focus on investing in B Corps, but B Corp status is very time and resource intensive to pursue. There are a few companies in the space that have done it including MAPS and The Third Wave, but it’ll be a long road before we see a meaningful percentage of psychedelics companies adopt this style of doing business.

All of us from Auryn Fund, to Field Trip, to our own Tabula Rasa Ventures are trying hard to make sure that the future of this industry reflects the incredible community that’s built it. But we need to be having more open conversations along with detailed strategies for how to do investment right.

If you read the PALA story.

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Quick Guide to Psychedelic Startups

How to Raise Capital for a Psychedelic Startup: Industry Info You Need to Know

In the recent past, psychedelics were considered dangerous drugs. Today, more and more scientists recognize their medical potential. Investors are already investing in the young industry.

Psychedelic drugs have a complicated history. They had a heyday in the 1960s but then fell into disuse. Recent research has partially brought psychedelics back. Today, scientists see them as promising compounds for treating many diseases.

Given the above, it is quite fair to say that the era of the so-called psychedelic renaissance has begun. Since 2020, the number of psychedelic companies has started to increase greatly.

Let’s take a look at the reasons for the increased demand in the psychedelic industry. Learn how to raise capital dealing with this type of business.

Psychedelics Boom

Despite Covid-19 and the collapse of the economy, investors are starting to pay attention to this industry. They bet that psychedelic-derived drugs can become a real business and help millions of people. Researchers, activists, and journalists have been the driving force behind the psychedelic renaissance.

Benefits of Psychedelics

Many startup companies are developing drugs based on psilocybin (the active ingredient in magic mushrooms), LSD, MDMA, and ibogaine. They are banned in the United States, except ketamine, which is also used in the development of such medicine. These companies hope to develop a psychedelic therapy treatment for a wide range of mental illnesses. They include depression, anxiety, addiction, and post-traumatic stress disorder (PTSD).

Medical regulators are also gradually turning toward psychedelics, as they show potential in treating depression. In 2019, the Food and Drug Administration (FDA) called Usona Institute’s psilocybin program for major depressive disorder “breakthrough therapy.”

However, researchers will have a tough road to winning FDA approval.

How Medical Companies Turned to Psychedelics

In early 2020, the drug company Mind Medicine (MMEDF) went public. It received the financial backing of Kevin O’Leary and the guidance of cannabis entrepreneur Bruce Linton. In one interview, O’Leary explained his reasons for investing in psychedelics and talked about the lagging efforts to treat growing psychiatric disorders.

In 2013, Linton became a co-founder of Canopy Growth (CGC), the largest cannabis company in the U.S. He left in 2019 and later became director of Mind Medicine. The main goal of the company is similar to Compass Pathways. They plan to bring psychedelics to market and conduct research on LSD, mushrooms, and other drugs.

Investing in Psychedelics

Venture capital investors were at the centre of the psychedelic boom. In early 2020, startups in the field said they were beginning to see signs of growing investor appetite.

Venture capital firms focused on psychedelic companies soon began to appear. Insider’s list of the top 11 venture capitalists in the field shows $139.8 million invested in such startups in just a few years.

Kevin O’Leary and PayPal co-founder Peter Thiel make big bets on magic mushrooms. Their big plans for mind-altering mushrooms have nothing to do with festivals or raves but deal with biotech instead.

Negev Capital, a psychedelic medical intervention investment fund, invests in companies that are developing new drugs to treat mental disorders based on psychedelic compounds. Negev has invested in 20 psychedelic drug development companies and has more than $30mln under the management

The fund recently doubled down on its substantial investment in Small Pharma Inc, a neuropharmaceutical company specialising in developing new treatments for mental illness with a focus on depression.

Another representative of psychedelic medicine is ATAI Life Sciences. It’s a “drug discovery platform” from Germany. The company invests in research of possible uses of psychedelics and other drugs for medical purposes. As of January 2021, they had raised more than $210 million, much of it from Thiel Capital and Christian Angermayer.

ATAI Life Sciences has taken a majority stake in Recognify, which was founded by Thomas Südhof, winner of the 2013 Nobel Prize in Physiology and Medicine. Recognify’s aim is to develop drugs to help treat schizophrenia. The company focuses on cognitive impairments (CIAS) that interfere with verbal learning and memory. Their new drug, RL-007, although not derived from psychoactive compounds, has already undergone positive clinical trials.

Atai Life Sciences Goes Public; Now the Largest Publicly Traded ...

Another company is Compass Pathways (CMPS), which went public in the United States back in September 2020. The British company, invested in by Thiel and Angermayer, has patented a synthetic form of psilocybin. It helps people with treatment-resistant depression.

The company launched clinical trials that involved 233 patients at several sites across Europe and North America. It is the most rigorous trial on psilocybin, which adds great weight to previous, smaller studies of the drug. In November 2018, FDA called the company’s treatment “breakthrough therapy.” This means the approval may come soon if trials are successful. Compass will start Phase 3 trials in the near future.

Cybin is a biotech company focused on the development of psychedelic therapeutics. In October 2021, it completed its 74th pre-clinical study of psychedelic compounds for potential therapeutic applications in several psychiatric disorders. Over 50 new compounds have been evaluated with the help of experienced contract research organizations.

Image result for Cybin is a biotech company focused on the development of psychedelic therapeutics. In October 2021,

The company seeks to build a portfolio of world-class psychedelic molecules that could become commercially viable drug candidates for both internal development and future partnerships.

The current psychedelic boom is only the beginning of the industry’s development and expansion. Considering investors’ attention to this type of medicine, more startups will emerge in the future. Active research on psychedelics has resumed in recent years, after its peak in the 1950s and 1970s. It may lead to great scientific progress and heal millions of people.

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Many startup companies are developing drugs based on psilocybin (the active ingredient in magic mushrooms), LSD, MDMA, and ibogaine. They are banned in the United States, except ketamine, which is also used in the development of such medicine. These companies hope to develop a psychedelic therapy treatment for a wide range of mental illnesses. They include depression, anxiety, addiction, and post-traumatic stress disorder (PTSD).

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“Hempy 1st Anniversary” Florida! July 1st, 2020



It is hard to believe that it has been only One Year since the full Legalization of CDB in the USA.

Depending on where you live, you may have started to see “CBD” products – capsules, tinctures, salves – pop up in your natural food stores or even at the supermarket. With all the misinformation out there, you may have questions about the health benefits of this non-psychotropic medicinal as well as its different forms and delivery methods. Understanding how CBD works and what’s available can steer you toward a product that works best for your individual needs.

Wide-Ranging Benefits

CBD, aka cannabidiol, is a compound found in the cannabis plant, but unlike THC, CBD is non-psychoactive and non-intoxicating, meaning there’s no “high” associated with it, making it much more tolerable for a wider variety of people and the reason it has received so much attention as of late.

While the FDA does not allow companies to make health claims about CBD products, there’s enough anecdotal evidence to suggest it can be a very effective, natural medicine.

For example, the Medical Board of California’s “Guidelines for the Recommendation of Cannabis for Medical Purposes” names medical conditions including cancer, anorexia, AID’s, chronic pain, spasticity, arthritis, and migraines as conditions that respond well to cannabis treatments.

So, why is CBD so effective in treating such a wide array of conditions? CBD acts as a regulator of the endocannabinoid system (ECS), a communications system in the brain and body that plays a pivotal role in homeostasis. Homeostasis helps to regulate vital functions in the body like the immune, digestive, central nervous, and cardiovascular systems. The EC system, therefore, plays an important role in body functions like sleep, perception of pain, metabolism, cognition, and pleasure, and CBD helps modulate these functions. The list of conditions CBD may treat continues to grow, but the following have the most anecdotal evidence.

Sleep

CBD improves the quality of sleep by helping people fall asleep and stay asleep. While it’s been shown to assist with sleeping disorders like insomnia, it also alleviates the symptoms that disturb a good night’s sleep, such as stress, anxiety, and restlessness.

Pain Management

Because CBD is an anti-inflammatory, it’s great for pain, especially with conditions like arthritis, fibromyalgia, migraines, cramps, and even gut-related disorders like colitis and Crohn’s disease. A 2012 study published in the Journal of Experimental Medicine found that CBD significantly reduced chronic inflammation and neuropathic pain in animals. If you have chronic pain, consider a regular CBD regimen as this will likely prove more effective than just taking it once in a while.

Stress, Anxiety, and Depression

CBD calms the body and mind, alleviating stress and stress-related disorders, improving cognitive functions and mood, reducing anxiety (general, social anxiety disorder, obsessive-compulsive disorder), trauma-related disorders like PTSD, and depression.

Neurological Conditions

There is strong scientific evidence that CBD effectively treats neurological conditions like Alzheimer’s disease, Parkinson’s, multiple sclerosis, and epilepsy. For example, well-known documented cases if CBD shows it reducing the severity and number of seizures in children who were previously unresponsive to anti-seizure medications. The CBD-heavy cannabis strain “Charlotte’s Web” was created specifically for Charlotte Figi, who was diagnosed with Dravet Syndrome, a rare and severe form of epilepsy that was causing her to have 300 grand mal seizures a week.

Cancer-Related Symptoms

This includes nausea, vomiting, and lack of appetite associated with chemotherapy, as well as pain. Although more research needs to be conducted, CBD used in combination with chemotherapy could assist in combating cancer cells and suppressing cancer cell growth overall.

Hemp – vs. Cannabis-Extracted CBD

Depending on where you live, you have two CBD choices: CBD derived from hemp or CBD derived from THC.

CBD can be extracted from cannabis and hemp, and there’s a reason why that matters. If you were to see a cannabis plant and a hemp plant next to each other, you’d be hard-pressed to tell the difference. They look the same because they come from the same plant species: Cannabis sativa. The difference is that in order for a plant to be classified as “hemp,” it has to be bred to contain very low levels of THC, the principal psychoactive constituent of cannabis {i.e., what causes a “high”} – less than .3 percent to be exact. When CBD is derived from hemp, there are only minute traces of THC, whereas CBD that comes from cannabis can have larger amounts of THC present. If you are sensitive to THC or you don’t want to experience possible psychoactive effects, you’re better off sticking with hemp-derived CBD. But if you’re not sensitive to a little THC, there are benefits to cannabis-derived CBD.

Hemp-Derived CBD

The 2018 Farm Bill legalized the cultivation of hemp, removing hemp and hemp-derived products from its former Schedule 1 status within the Controlled Substance Act, making CBD derived from hemp federally legal in the U.S. so that it’s accessible to anyone that wants to try it.

At your local health food store, you’ll typically find CBD oil, capsules, tinctures, salves, and edibles like chocolate. The dosage of these products varies, and where to start depends on your tolerance and ailment. Taking 10-25 mg of CBD is a great place to stat for newbies. If you’re especially sensitive to medications you may wish to start at 5 – you may not feel the effects of the medicine, but it will provide a gauge for how your body will respond.

Once you’ve experimented a bit with the options, you may wish to branch out. You can go online and search “hemp-derived CBD products” and find a multitude of choices, but here’s where things get a bit tricky. While the FDA has regulatory authority over CBD, it has not established any definitive set of rules for the industry other than barring cannabidiol products from being sold as dietary supplements. As a result, there are serious quality control issues in the market at the moment. Products can be poorly labeled, have inconsistent quality and/or be overly processed, or they might contain toxins like pesticides, mold, and solvent residues. You will need to research reputable brands to find good-quality CBD.

Look for products that have been tested by a third-party lab, ensuring that the product is microbial, pesticide, and solvent-free. This includes all pages of the report, showing what you don’t want it to have. Buy CBD products made with organic, American-grown hemp or cannabis. Consumer Reports suggests looking for products made in states that have legalized the recreational and medical use of cannabis since they have more regulations and testing procedures in place.

Cannabis-Derived CBD

If you live in a state where recreational use is legal, you can try CBD products from a licensed dispensary. The same goes if you live in a state where medicinal use is legal and you have your medical marijuana card.

While CBD derived from hemp has only trace amounts of THC, CBD derived from cannabis will include various amounts. Some people prefer cannabis-derived CBD, as the two cannabinoids -CBD and THC – work very well together, creating what’s known as the “entourage effect,” where each enhances the therapeutic benefits of the other.

There are strains of cannabis bred specifically to be high in CBD and low in THC, including ‘ACDA,’ ‘Cannatonic,’ ‘Charlottes Web,’ ‘Ringo’s Gift,’ ‘Sour Tsunami,’ ‘Harlequin,’ and ‘Hawaiian Dream.’

With extracts like CBD oils and tinctures, you can find different ratios available. A ratio of 1:1 for example, means there are equal parts CBD to THC. If you don’t want to be “high” or prefer milder psychoactive effects from the THC, look for high CBD ratios like 15:1, 10:1, and 7:1. For some, having just a little THC enhances the overall benefits of CBD without any negative side effects.

Full Spectrum CBD Oil. (Not Hemp Oil)

Because CBD has only just been legalized, it will take a while for scientific research to back up mounting anecdotal evidence of its therapeutic profile and medicinal benefits, but you can be sure it’s coming.

Isolate, Full Spectrum, and Broad Spectrum CBD

When shopping for CBD products, you’ll find three choices that relate to the extraction process: isolate, full-spectrum, and broad-spectrum.

◦ CBD isolate is more than 99 percent pure CBD – the CBD molecules are isolated from the other parts of a hemp or cannabis plant.

◦ Full Spectrum CBD also called “whole-plant formula,” extracts CBD along with other beneficial phytocannabinoids, including trace amounts of THC as well as terpenes and flavonoids.

◦ Full Spectrum CBD (THC FREE) is like full spectrum but contains zero THC. A product such as that is like HempSMART. While CBD isolate is pure CBD, researchers believe that full and broad-spectrum extracts offer more therapeutic value, as they’re more bioavailable and activate more benefits.

10mg CBD Oil

Delivery and Dosage

How you choose to consume CBD depends on what you wish to treat, the effect you hope to achieve, how long you want it to last, and what feels the most comfortable and convenient for you. No “dosing protocol” or medical predictability exists, which makes dosing a bit tricky, so you’ll have to do some experimentation. ‘Low and slow” is key: start with a low dosage and take it slow. Although you cannot die from a cannabis overdose (there’s not a single documented case in the world), you can “over dose” yourself, resulting in symptoms like high anxiety and paranoia from intense psychoactive effects. Don’t rush the process; start with 5-10 mg and go from there.

Smoking or Vaporizing Flower

“Flower” refers to the trichome-covered part of a female cannabis plant. As mentioned, there are strains of cannabis bred specifically for high amounts of CBD and low THC. The benefit of smoking or vaporizing (“vaping”) flower is that the effect is felt almost immediately, making self-regulation of dosage fairly easy. If you have health issues and don’t want to smoke, you can put flower into a vaporizer, an electronic device that heats dried flower to vapor. The issue with vaping is that the higher temperatures inhabit the full benefits of the plant.

CBD Oil Capsules

Also called “canna caps,” these contain a concentrated extraction of CBD. Fast-acting because they’re so easy to metabolize, they’re also discreet and the dosage is easy to control. Read the label, but capsules typically work for 4-6 hours.

CBD Oil Tinctures

These are extracted from flower or plant matter using alcohol, oil, or vegetable glycerin. Dropped sublingually under the tongue, CBD absorbs immediately into the bloodstream. People like tinctures because they’re easy to control, discreet, and fast-acting.

Buyer Beware: A product labeled as “hemp oil” is not necessarily a CBD product. Read the label carefully to see how much CBD it contains. A product labeled “hemp seed oil” does not contain CBD naturally, unless it has been added.

CBD Infused Edibles

From chocolate to gummies to beverages, CBD edibles come in an incredible variety of forms. Edibles require a bit more time to take effect because the digestive system has to break them down, so depending on what’s already in your stomach and how fast your metabolism works, they may take anywhere from 1-3 hours to kick in, and the effect can last between 4-8 depending on the dosage. For this reason, more than any other delivery method, low and slow is the key with edibles. Start with no more than 10 mg and wait and see how you feel.

At the end of the day, our physiology is complex, so it will likely some trial and error to figure out what works for you. Consider keeping a journal, noting what you tried, the dosage, how long it took to kick in, how long it lasted, and how it made you feel – and whether it worked beneficially for your body.

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