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180 Life Sciences Corp. has selected a lead synthetic CBD analogue that is expected to move forward in clinical development.

MENLO PARK, Calif., July 28, 2021 180 Life Sciences Corp, a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain, announced today that it has selected a lead Synthetic CBD Analogue that is expected to move forward in clinical development for both inflammation and pain.

As part of a continuing collaboration since 1998 with the pioneer of cannabis chemistry, Raphi Mechoulam (Hebrew University, Jerusalem), Sir Marc Feldmann’s (the Company’s Co-Executive Chairman and Co-Founder) laboratory, and 180 Life Sciences’ scientists, identified the non-psychoactive CBD analogue as a lead molecule in the Company’s SCA platform.

The analog was selected based on a wide-ranging screen of derivatives of cannabidiol and cannabigerol made by Prof Mechoulam.

The Company believes that the analog appears to have (1) a novel composition of matter which would enable patent protection, (2) robust preclinical efficacy in several established mouse models for treating pain and inflammation in vivo , and (3) ease of scalability for future good manufacturing practice (GMP) manufacturing. Its safety profile is being explored in greater detail.

Dr. James Woody, 180 Life Sciences’ Chief Executive Officer, stated, “We believe that our lead compound HUM-217, a CBD derivative generated by cannabis chemistry pioneer Prof Raphael Mechoulam, meets all the criteria desirable to advance to clinical development. We look forward to continuing to pursue new therapeutics for one of the world’s largest drivers of disease, Inflammation.”

Prof Sir Marc Feldmann, 180 Life Sciences Executive Co-Chairman added, “It is a real pleasure to announce the progress that has been made, which we believe is a significant step forward towards the more effective use of pure synthetic cannabinoids in medicine. We look forward to continuing the development of these compounds in clinical trials.”

*About 180 Life Sciences Corp. 180 Life Sciences Corp. is a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. 180 Life Sciences is leading the research into solving one of the world’s biggest drivers of disease – inflammation. The Company is driving groundbreaking studies into clinical programs, which are seeking to develop novel drugs addressing separate areas of inflammation for which there are no effective therapies. The Company’s primary, most advanced platform is a novel program to treat fibrosis using anti-TNF (tumor necrosis factor) which is in the clinic.

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CBD Honey? No Really, May Bee the Solution.

“Hemp is a high pollen producing crop flowering during a period of floral resource scarcity and supports a diverse array of bees in the northeastern U.S. landscape.”

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In a new study published in the journal Environmental Entomology, researchers in the Department of Entomology at Cornell University in New York wondered if the growing legalization of cannabis for recreational, medical and industrial purposes is having any effect on bees.

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While marijuana is becoming in New York, industrial hemp is a fast-growing industry and the flowers are essentially the same. In a simple test (repeat visits to New York hemp farms and collected bees with nets), the researchers found 16 different bee species happily buzzing around the buds.

That variety highlights the “species richness” of Cannabis sativa when it comes to attracting bees.

“Industrial hemp offers a unique floral resource to bees in agricultural landscapes. Hemp flowers late in the summer releasing an abundance of pollen during a period of native and agricultural floral dearth. As a result, hemp pollen may offer a vital subsistence resource to bees at a point in the season when they are resource-limited, thereby helping to alleviate the pressures imposed by spatial and temporal variation in resource availability that is characteristic of simplified agricultural landscapes.”

The researchers weren’t as concerned about the growing creation of cannabis honey (we know you are – hang on) as much as how the dominance of cannabis would affect the bees.

It turns out that besides being attractive to a diversity of bees, cannabis blossoms in the late summer when most other plants are finished and bees are looking for pollen. By extending their season, cannabis may actually be helping to strengthen the bees to fight off the diseases that have decimated their populations in recent years. What about the cannabis honey?

Right.

Most products labeled cannabis honey are actually infused with CBD or THC.

While beekeepers claim the honey from bees specializing in cannabis flowers contains cannabinoids, it’s tough to differentiate between benefits that might come from them and the natural benefits of honey.

The Israeli cannabis technology company PhytoPharma International is offering pure, non-infused, highly bioavailable cannabis-derived honey called Pure Bee.

It’s available in two forms — non-intoxicating CBD Honey and psychoactive THC Honey – and is said to take effect in 10 minutes, much faster than most edible cannabis products.

So, do bees really get a buzz from marijuana? Unfortunately, no. Bees lack cannabinoid receptors and merely pass them on to their honey.

They buzz the buds merely for the fun and the exercise.

That’s just another good reason to be kind to bees.

 

 

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8 – 8 – 2021 Happy CBD Day! From Inspirational Technologies

About National CBD Day The CBD industry celebrates National CBD Day on August 8 every year.

 The CBD community continues to commemorate CBD Day, which focuses on educating and creating awareness about CBD among consumers through media coverage and social media.

Issues covered include ongoing studies, CBD uses, and its benefits. However, CBD brands also provide deals to enjoy during this holiday.

 

CBD is a derivative of hemp, which has faced its share of political problems, with leaders banning its use.

The hemp plant has been around for centuries, with growers using it for fiber and other things. However, it was until 2018 that hemp became legal federally.

The 2018 Farm Bill that became law recognizes hemp as legal if it has 0.3% THC or less.

The CBD industry continues to gain popularity as more people learn of CBD’s potential wellness benefits.

 

Today, you can utilize CBD in a variety of ways. Users can consume CBD in the form of oil or capsules or choose delicious gummies, which come in various mouth-watering flavors.

Brands also provide CBD topicals like creams and salves that offer targeted relief on affected body parts only.

However, preliminary research has shown CBD to help with pain, stress, anxiety, and inflammation, among other benefits. However, more studies are needed to provide additional data on CBD’s capability to alleviate such health conditions and others.

 

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Six Steps To Better Sleep

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SIX WAYS TO BETTER SLEEP

If you’re like one of the millions of Americans who struggle to get restful sleep, consider implementing these steps into your bedtime routine. Hempsmart Smart Drops are a great addition to your sleep routine, helping you achieve more restorative sleep and overall well-being. hempsmart™ hempsmart™ hempsmart™ is committed to using only the highest quality all-natural ingredients, cutting edge science-based formulations, and premium broad-spectrum hemp extracts in therapeutic amounts to formulate our product-lines with a sophistication and effectiveness beyond compare. It is our goal to help transform personal health into planetary health.

If you’re like one of the millions of Americans who struggle to get restful sleep, consider implementing these steps into your bedtime routine. 

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CBD vs. THC: What Are the Differences? Why it Matters.

Concern about the dangers of marijuana abuse led to the banning of cannabinoids for use in the U.S. and many other countries in the 1930s and 1940s.

It took decades until they came to be considered again as compounds of value, and even now their uses are highly restricted. What Is Cannabis? Cannabis is a naturally growing herb that has been used for thousands of years to treat health conditions

. It’s also used in perfumes, soaps, candles and some foods. Cannabis originated in Central Asia, but today it’s grown worldwide. The term cannabis (popularly known as marijuana) is used to describe a product of the Cannabis sativa plant that is bred for its potent, sticky glands that are known as trichomes. These trichomes contain high amounts of tetrahydrocannabinol (called THC), which is the cannabinoid most known for its psychoactive properties. Cannabis Components Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely by cannabis species. These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (known as THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol, cannabichromene, cannabigerol, tetrahydrocannabivarin and delta-8-THC. Cannabis vs. Hemp Hemp oil — obtained by pressing benefit-rich hemp seeds — is slightly different than cannabis oil, although they both come from the same genus, Cannabis, and the same species, Cannabis Sativa. The term hemp is used to describe a Cannabis Sativa plant that contains only trace amounts of THC. Hemp is a high-growing plant that’s commonly grown for industrial uses, such as oils and topical ointments, as well as fiber for clothing, construction, paper and more. Cannabis Oil vs. CBD Oil Cannabis oil and CBD oil are not the same thing. So what is CBD oil? Cannabidiol (CBD) oil has a high concentration of cannabidiol, while cannabis oil contains both CBD and THC. CBD oil is created by extracting CBD from either the cannabis or hemp plant and then diluting it with a carrier oil like coconut or hemp seed oil. CBD does not produce a euphoric “high” or psychoactive effect because it doesn’t affect the same receptors as THC. CBD cannabis oil or CBD hemp oil are both said to be non-psychoactive. However, it gets confusing because any oil that is CBD-dominant is considered a CBD oil, and it produces different effects from THC-dominant cannabis oils. Most CBD oil comes from industrial hemp, which typically contains more CBD than marijuana. History According to the U.S. National Library of Medicine, cannabis use dates back at least 3,000 years. It was introduced into the Western mindset in the 1840s by W.B. O’Shaughnessy, a surgeon who learned of its beneficial properties while working in India for the British East Indies Co. In 1937, the U.S. Treasury Department introduced the “Marihuana Tax Act,” which imposed a levy of $1 per ounce for “health-focused” use of cannabis and $100 per ounce for recreational use. This was opposed by physicians who were not required to pay a special tax for prescribing cannabis, use special order forms to obtain it and keep records detailing its professional use. The American Medical Association believed that evidence of cannabis’ harmful effects was limited and the act would prevent further research into its worth health-wise. By 1942, cannabis was removed from the U.S. Pharmacopoeia because of persistent concerns about its potential to cause harm. Final Thoughts While studies have certainly shown the benefits of cannabis used for some health purposes, there are many strains of cannabis, and they are not all equal. If you are using cannabis oil, make sure it is purchased through a reputable and lab-tested company. Last but not least, remember that cannabis is a very powerful oil, and only small amounts are needed for it to have a powerful effect on the body and mind.

 

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Florida Department of Agriculture and Consumer Services for a town hall meeting with the Cannabis Director on May 27th, from 3:00 – 4:00 p.m.

Replay available 5/28/2021  Go to Http://lims.flaels.org to register.
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Hello, 

This is a reminder to join the Florida Department of Agriculture and Consumer Services for a town hall meeting with the Cannabis Director on May 27th, from 3:00 – 4:00 p.m.

Please see the attached agenda for more information.

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Join on your computer or mobile app
Click here to join the meeting
Or call in (audio only)
+1 850-391-8548,,993606967# United States, Tallahassee
Phone Conference ID: 993 606 967#

May 27, 2021 Agenda
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