Posted on 03/12/202205/30/2022 by Steven M Smith — Leave a comment

Your Endocannabinoid System and What is it?

OVER THE LAST TWO DECADES, RESEARCH ON THE EFFECTS OF CANNABIS ON THE HUMAN BODY LED TO THE DISCOVERY OF THE ENDOCANNABINOID SYSTEM.

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The endocannabinoid system (ECS) is a network of CB1 and CB2 cell receptors and the molecules that act on them. CB1 receptors are found mostly in tissues of the brain and the central nervous system (CNS).

CB2 receptors are found in the immune system, gastrointestinal tract, retina, and peripheral nervous system.

CB1 is expressed in the tissues of both the central nervous system (CNS) and the periphery, with a predominant expression on presynaptic nerves.

CB2, sometimes referred to as the “peripheral cannabinoid receptor”, is mainly expressed on immune cells but can also be found on other peripheral tissues such as the retina and in the CNS(Croxford and Yamamura 2005; Mackie 2006).

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Endocannabinoids act on CB1 and CB2 receptors to regulate core body functions, including metabolism, appetite, sleep, mood, pain, immune function, and muscle movement.

An irregularity of the ECS can result in pain, digestive issues, seizures, mental health concerns, and problems with mobility and balance. Endocannabinoids in the body are degraded by fatty acid amide hydrolase (FAAH).

See the source image — Fatty acid amide hydrolase

Cannabidiol (CBD), another component of medical marijuana, inhibits FAAH, allowing more naturally occurring endocannabinoids to remain active in the body.

Imbalances of the endocannabinoid system are associated with many diseases, explaining why medical marijuana has a beneficial effect on a variety of medical conditions.

Current research on the endocannabinoid system is seeking new treatments for autoimmune, inflammatory, and neurodegenerative diseases, as well as non-addictive ways to relieve pain.

The delta9-Tetrahydrocannabinol (THC) in marijuana resembles the endocannabinoid molecules, anandamide and 2-Ag, manufactured by the human body.

THC binds with CB1 and CB2 receptors to replace or augment naturally occurring endocannabinoid.

Balancing Your ECS Balancing Your ECS

CBD has been all the buzz.

The use of CBD products like tinctures, full-spectrum CBD oil, CBD gummies, and CBD soluble water as supplements has skyrocketed. And for good reason. CBD”s purported therapeutic benefits are more than enough to warrant attention.

Though studies are still ongoing, early signs from research indicate it might help with:

Memory – Mental health – Reward circuits – Digestion – Appetite – Immune system – Cardiovascular system – Skin, and much more.

So, how is it really that one compound might hold such a broad range of benefits?

What is the underlying mechanism that might just make all these benefits possible?

To know the answer to that, you first need to know about your Endocannabinoid System (ECS).

The Endocannabinoid System and Balancing Your ECS Unbeknownst to many CBD consumers, taking CBD supplements affects the equilibrium of their endocannabinoid system.

People worldwide are now taking or heavily considering taking CBD because its purported benefits might help them manage some conditions.

However, these benefits in themselves are simply the outcome of improving your bodies’ internal balance.

And that is precisely what the Endocannabinoid system actually does.

What Is the Endocannabinoid System (ECS)?

The Endocannabinoid System (ECS) is a neurotransmitter system that consists of a series of receptors found throughout the mammalian body. These receptors are in some of the most important structures inside your body, from the brain to all peripheral organs.

These particular receptors interact with endogenous cannabinoids/endocannabinoids.

The resulting interaction controls a vast array of physiological functions, including pain, appetite, mood, immune system, memory, and much more.

The Composition of the ECS

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Balancing Your ECS – How to Go About It the endocannabinoid system covers the brain to the most important organs

Three different components make up the endocannabinoids systems: Cannabinoid Receptors

There are two kinds of cannabinoid receptors: the CB1 receptors and the CB2 receptors.

Located on cell surfaces, what characterizes cannabinoid receptors is their interactions with their namesake, the cannabinoid compounds.

Said interactions result in the therapeutic benefits people say they experience when taking CBD, which is just one of many cannabinoids.

Since the ECS strives to achieve homeostasis in the body, the therapeutic effects are simply its way to achieve that end.

Usually, the body would use the endocannabinoids it produces on its own to do so.

Yet, by taking CBD products, you can help trigger said effects.

CB1 receptors are in high-density within the brain and the nervous system.

Therefore, they do influence brain functions, such as memory and appetite.

THC, the psychoactive cannabinoid that causes the marijuana high, binds to CB1 receptors hence the ‘high’ you experience with it.

On the other hand, CB2 receptors are most prevalent in the body organs, muscle tissues, immune system, and bones.

They influence the body’s pain managing response, particularly, the anti-inflammatory response.

Endocannabinoids

Endocannabinoids are cannabinoids produced by our own bodies.

They interact with and activate the CB1 and CB2 receptors, with each cannabinoid causing different body changes.

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Despite their origins, they are remarkably similar in structure to Phyto cannabinoids, the cannabinoids found in plants like industrial hemp or cannabis.

CBD itself is one Phyto cannabinoid found on those plants.

Enzymes ECS enzymes’ primary function is to break down and recycle endocannabinoids, thereby frequently making sure your body achieves homeostasis.

The Fatty acid amide hydrolase (FAAH) enzyme breaks down anandamide, arguably the most important endocannabinoid.

The other major enzyme, the Monoacylglycerol lipase (MAGL) enzyme, breaks down the 2-AG once they have finished their work.

What Are the Endocannabinoids?

As mentioned above, endogenous cannabinoids, better known as endocannabinoids, are cannabinoids produced by the body.

The two main endocannabinoids include 2-arachidonoyl glycerol (2-AG) and anandamide (AEA).

2-AG seems to control appetite and the immune system. On the other hand, anandamide regulates mood.

When your body experiences imbalances, the ECS initiates a response to restore physiological balance, thereby achieving homeostasis.

What Is Homeostasis and Why It Is Important

The primary function of ECS is to achieve homeostasis.

So, what is homeostasis?

In simple terms, homeostasis means balance. Regarding health matters, homeostasis refers to achieving balance in our internal environment.

Body organs and, by extension, the human body, functions optimally in specific conditions.

Body homeostasis ensures every part of our body is within the right working range and, therefore, functions correctly.

The strife for homeostasis is evident in bodily functions such as temperature regulation, where you sweat to cool down or shiver to warm up.

The ECS plays a massive role in achieving balance in our internal systems, despite the tremendous external environment changes.

What Might Cause ECS Imbalance?

Many environmental factors and situations put stress on our bodies.

Often times, said stress it so much it overwhelms our systems and throws our internal balance into disarray.

Now more than ever, we are particularly exposed to said factors and situations.

By adequately identifying what might negatively affect us, we have the chance to avoid them or, at least, better control the outcome it has on our internal balance. Here are some of the things you should better control if you are looking to balancing your ECS.

Poor Diet

Research establishes that endocannabinoids produced in the periphery organs control our appetite.

Unfortunately, consuming a diet consisting of high sugar and fat levels can harm the endocannabinoid system, causing an imbalance.

Such diets increase the endocannabinoids produced in the intestines and circulating in the blood.

Consequently, the individual is at risk of developing hyperphagia. Hyperphagia is an abnormal desire for food, causing one to consume larger meals much more frequently.

Thus, making them very likely to become obese. Once someone has a lot of fat mass due to an unhealthy diet, the increased fat cells start to produce more endocannabinoids.

This, in turn, will further their desire to continue to eat a lot frequently. The production of endocannabinoids by fat cells is among the reasons why losing weight is difficult.

Emotional Stress

Research indicates that the ECS system plays a vital role in regulating the stress response. Everyday short-term stress is helpful, and in many ways, it is critical to our survival. When exposed to stress, your body will respond by reducing the anandamide levels.

Thus, causing you to feel stressed, anxious, or agitated. At the same time, stress causes an increase in the production of 2-AG, which reduces pain reception. 2-AG also enhances your cognitive functions, including memory, to help you get out of danger.

However, exposure to chronic stress causes desensitization of CB1 receptors. The high levels of 2-AG overstimulate the CB1 receptors.

(Abstract

The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are N-arachidonylethanolamine and 2-arachidonoylglycerol; together the endocannabinoids and CB1R subserve activity dependent, retrograde inhibition of neurotransmitter release in the brain. Deficiency of CB1 receptor signaling is associated with anhedonia, anxiety, and persistence of negative memories. CB1 receptor-endocannabinoid signaling is activated by stress and functions to buffer or dampen the behavioral and endocrine effects of acute stress. Its role in regulation of neuronal responses is more complex. Chronic variable stress exposure reduces endocannabinoid-CB1 receptor signaling and it is hypothesized that the resultant deficiency in endocannabinoid signaling contributes to the negative consequences of chronic stress. On the other hand, repeated exposure to the same stress can sensitize CB1 receptor signaling, resulting in dampening of the stress response. Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endocannabinoid/CB1 receptor signaling provides resilience against the development of stress-related pathologies.)

The body compensates this by desensitizing or reducing the number of CB1 receptors. Consequently, this creates an imbalance in the ECS system. Disease Research linking ECS imbalance to arthritis, depression, PTSD, Parkinson’s disease, schizophrenia, and other diseases is underway. That said, there are indications that certain conditions might have more than a casual relationship with ECS imbalance.

This theory might explain why some patients might better manage their ailments by taking CBD products to rebalance the ECS.

In other instances, the ECS imbalance seems to cause the disease.

Drugs Studies indicate some pharmaceutical and recreational drugs, including alcohol, stimulate an increase in endocannabinoids’ production.

Thus, it might overstimulate cannabinoid receptors, especially CB1 receptors. Consequently, the body downregulates receptors as a compensation mechanism, thereby creating an imbalance in the system.

Your Genetics

There are cases where individuals have inherent ECS unbalances built into their genetic makeup.

Unfortunately, these are something they cannot get rid of completely.

For instance, a 2015 discovery reported in the New York Times indicates that approximately 20% of Americans have a mutation that degrades the anandamide.

Such individuals have an inherent imbalance that compromises their response to stress while increasing their risk of suffering from obesity.

The Best Methods for Balancing Your ECS

Balancing Your ECS – How to Go About physical exercise is one of the most fun ways of balancing your ECS

When such imbalances arise, one possible way of achieving homeostasis is to supplement your diet with CBD products.

CBD interacts with CB1 receptors, thereby supplementing the endocannabinoids in your body that are not enough to restore balance at a given moment.

The compound also boosts the endogenous cannabinoids by reducing their breakdown.

By preventing the degradation of endocannabinoids, CBD ensures your body has an ample supply of homeostasis-inducing compounds. Aside from supplementing with CBD, there are also other means of balancing your ECS, including: Physical Exercising

Engaging in physical exercise is known for its benefits in maintaining a healthy weight level.

Additionally, exercise can also elevate the anandamide levels in your blood, which rebalances the ECS. The increased 2-AG in your blood also enhances your ability to manage pain and reduce anxiety and stress, improving your mood.

Taking Herbs

Some herbs and teas contain compounds that enhance ECS balancing. Herbs containing the terpene beta-caryophyllene such as cloves, oregano, black pepper, and cinnamon can help balance the ECS.

This compound only stimulates the CB2 receptors and helps combat inflammation. Fasting While unconventional, fasting can help balance your ECS. Being in a fasted state enhances increases the 2-AG levels in your body as your body stocks hunger.

The elevated amount of 2-AG will still yield anandamide’s associated benefits, including inflammation and anxiety relief. Eating A Healthy Diet Consuming a poorly-balanced diet consisting of high omega-6 fatty acids induces imbalances in your ECS.

To counter this, you should prioritize consuming a balanced diet with an ample supply of omega-3 fatty acids. Fatty acids from hemp milk, fish and fish oil, walnuts, chia seeds, and flaxseeds end up converting into endocannabinoids.

Thus, help you in balancing your ECS. Detoxing Abusing alcohol, THC, and other recreational and pharmaceutical drugs overstimulates CB1 receptors, thus, causing desensitization. You can counter these effects by detoxing.

Evidence suggests that the CB1 receptors can return to their natural state after months of detoxing. By detoxing and abstaining from drug abuse, your ECS will regain some balance in time.

Meditating

As mentioned above, chronic stress is one of the most common causes of ECS imbalance.

Thus, it’s better to relax. There are no studies yet on whether meditating can help balance your ECS.

However, some reports show mindful meditation as effective in quelling anxiety and stress, something that definitively counts as ‘relaxing.’

Enjoying Some Sunlight Basking in the sun is vital for more than getting some Vitamin D.

Solar UV light is essential in the production of 2-AG, especially during winter months.

Elevating 2-AG by soaking some sunlight can help rebalance your ECS system.

Balancing Your ECS –

The Takeaway

The modern world undoubtedly offers us an ever-increasing set of choices of things that might end up causing an ECS imbalance. It is then up to us to take matters into our own hands and be mindful of our habits.

Regularly engaging in habits that help balancing your ECS and limiting those that do not might go a long way in maintaining our internal balance. And with that, helps us feel better in our day to day lives.

Also, if you need to have a little extra help in balancing your ECS, there’s always CBD products.

Supplementing your endocannabinoids level with a Phyto cannabinoid may boost your ECS back into balance.

Just remember to talk with a doctor before taking CBD, especially if you are already on some other medication.

Inspirational Technologies – is Committed to Your Health Wellness Beauty and Enrichment

Reporting on Today’s Internal Botanical and Skin Product Benefits

4 Hemp Club was Inspired by Steven Smith’s vision

to “Have an older generation put the younger 4 H Club

envisioned. Our Platform Uses HEMP as an Agricultural

Focal Point, deserving of research, development and the

4 Hemp key points Hemp Health Hope and Happiness.”

Posted on 03/08/202203/08/2022 by Steven M Smith — Leave a comment

HAPPY INTERNATIONAL WOMENS DAY!

Happy International Women’s Day March 8th, 2022

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In Celebration, we at Inspirational Technologies will begin a SKIN CARE SERIES for all Women And Men. After all, we need to help each other.

WHY YOU SHOULD BE USING NATURAL HEALTH SKINCARE PRODUCTS

The human skin is the first line of defense against toxins and pathogenic microorganisms. It serves important purposes in keeping our internal organs safe while making sure we are protected from the harsh nature of UV radiation and pollution. The continued exposure to these processes may end up reducing the concentration of chemicals like hyaluronic acid in the skin, thus giving way to dry skin, inflammations and other skin-related diseases.

When this happens, we turn over to skincare products for refuge.

Click to Celebrate International Women’s Day

It will interest you to note that women use an average of 168 chemicals on their body through skin care regimen daily.

The application of these chemicals is expected to keep the skin healthy as they face their daily activities.

Although some of these synthetic chemicals may prove effective in taking care of skin-related issues it is pertinent to note that they are toxic to the skin and may be carcinogenic hence the need to rely on natural ingredients for relief.

Image result for natural health skincare products. Size: 158 x 105. Source: elementshealthspace.com

Some of the benefits of using natural health skincare products include but are not limited to the following:

a. Highly safe and reliable Most of the natural skin care products are formulated from naturally occurring chemicals with little to no side effects. Most of the raw materials or ingredients are found naturally in the skin; thus they only supplement their natural supply rather than introducing a strange chemical with potential carcinogenic properties.

b. It keeps your mind at rest With natural skin care products, no need to worry about the extra chemical or its effect on your body since it is naturally present in different concentration and applying the skin care product is only supplementing them.

c. Possess some health benefits The use of natural health skincare products offers your skin with a vast array of health benefits including hydration, wound healing, reduce inflammation, pain relief and reduced wrinkle formation. Applying these products to your skin keeps it as healthy as possible without any adverse side effect.

d. They are gentler on the skin Natural health skincare products are soft on the skin. They are not harsh, nor do they damage skin cells. Direct application of chemicals does not only damage your skin but may affect the immune system, nervous and reproductive system. Their harsh nature leaves the damages the skin while offering short term results.

e. Healthier environment Synthetic skin care products can serve as potential pollutants. These chemicals are not biodegradable and may find their ways into rivers where they increase the concentration of pollutants.

Hyaluronic acid and skin aging

The most dramatic histochemical change observed in senescent skin is the marked disappearance of epidermal HA, while HA is still present in the dermis.⁹² The reasons for this change in HA homeostasis with aging is unknown. As mentioned above, the synthesis of epidermal HA is influenced by the underlying dermis and is under separate controls from the synthesis of dermal HA.¹⁶^,⁹⁸ Progressive reduction of the size of the HA polymers in ski

n as a result of aging has also been reported.¹⁰⁹ Thus, the epidermis loses the principle molecule responsible for binding and retaining water molecules, resulting in loss of skin moisture. In the dermis, the major age-related change is the increasing avidity of HA with tissue structures with the concomitant loss of HA extractability. This parallels the progressive cross-linking of collagen and the steady loss of collagen extractability with age.¹⁶ All of the above age related phenomena contribute to the apparent dehydration, atrophy and loss of elasticity that characterizes aged skin.

Premature aging of skin is the result of repeated and extended exposure to UV radiation.¹¹⁰^,¹¹¹ Approximately 80% of facial skin aging is attributed to UV-exposure.¹¹² UV radiation damage causes initially a mild form of wound healing and is associated at first with an increase of dermal HA. As little as 5 min of UV exposure in nude mice caused enhanced deposition of HA, indicating that UV radiation induced skin damage is an extremely rapid event.¹⁶ The initial redness of the skin following exposure to UV radiation may be due to a mild edematous reaction induced by the enhanced HA deposition and histamine release. Repeated and extensive exposures to UV ultimately simulate a typical wound healing response with deposition of scarlike type I collagen, rather than the usual types I and III collagen mixture that gives skin resilience and pliability.¹⁶

In the skin, photoaging results in abnormal GAG content and distribution compared with that found in scars, or in the wound healing response, with diminished HA and increased levels of chondroitin sulfate proteoglycans.¹¹¹ In dermal fibroblasts this reduction in HA synthesis was attributed to collagen fragments, which activate α_vβ₃-integrins and in turn inhibit Rho kinase signaling and nuclear translocation of phosphoERK, resulting in reduced HAS-2 expression.¹¹³ We have recently unraveled some of the biochemical changes that may distinguish photoaging and natural aging. Using photoexposed and photoprotected human skin tissue specimens, obtained from the same patient, we have shown a significant increase in the expression of HA of lower molecular mass in photoexposed skin, as compared with photoprotected skin. This increase of degraded HA was associated with a significant decrease in the expression of HAS-1 and an increased expression of HYAL-1, -2 and -3. Furthermore, the expression of HA receptors CD44 and RHAMM was significantly downregulated in photoexposed, as compared with photoprotected skin. These findings indicate that photoexposed skin, and therefore extrinsic skin aging, is characterized by distinct homeostasis of HA.²⁹ We have also assessed photoprotected skin tissue specimens from adults and juvenile patients and observed that intrinsic skin aging was associated with a significant reduction in the content of HA and downregulation of HAS-1, HAS -2, CD44 and RHAMM.²⁸ Similar results for photoprotected skin have also been reported for both genders for HA, HAS-2 and CD44.¹¹⁴

Conclusion

The available data suggest that HA homeostasis exhibits a distinct profile in intrinsic skin aging, which is totally different of that in extrinsic skin aging. Additional insight needs to be gained in understanding the metabolism of HA in skin layers and the interactions of HA with other skin components. Such information will facilitate the ability to modulate skin moisture in a rational manner and may contribute to the refinement of current drugs and the development of novel treatments for skin aging.

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*This site receives compensation for referred sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research development discovery and healing.

Inspirational Technologies – is Committed to Your Health Wellness Beauty and Enrichment

Reporting on Today’s Internal Botanical and Skin Product Benefits

4 Hemp Club was Inspired by Steven Smith’s vision

to “Have an older generation put the younger 4 H Club

envisioned. Our Platform Uses HEMP as an Agricultural

Focal Point, deserving of research, development and the

4 Hemp key points Hemp Health Hope and Happiness.”

Posted on 03/06/2022 by Steven M Smith — Leave a comment

It’s In the Numbers for Cannabis. In the US, Beverages and Pre-Rolls saw the strongest year over year growth rates in 2021

Key takeaways: In the US, Beverages and Pre-Rolls saw the strongest year over year growth rates in 2021, while the Tincture & Sublingual category saw a decline in sales.

On the other hand, Tincture & Sublingual products in Canada, which were released in late 2020 with other ‘Cannabis 2.0’ products, saw over 3000% growth year over year.

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Flower market share is in decline in both the US and Canada. Sales from female consumers in the US have increased 55%, while sales from male consumers have increased 49%.

Gen Z consumers are quickly aging into the market, with US market share to this age group more than doubling over the last two years, from 8.3% to 15%.

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Vapor Pen wallet share decreases with customer age, while Edible wallet share increases with customer age.

Meanwhile, Pre-Roll wallet share is remarkably constant across age groups, indicating that the convenience and familiarity of a pre-rolled joint has universal appeal.

Both Gen Z and Millennial females logged much higher sales shares in Canada last quarter than their American counterparts. In fact, female customers overall contributed 36.7% of total sales in Canada while in America that value was only 32.6%.

Those are the trends and here are the products. When exploring product categories, reports found that certain categories have been more successful than others in the US and Canada.

This is likely caused by a steady decrease in customer participation in the category, rather than a decreased spend among customers who prefer flower.

Image result for cbd Beverage category

The Beverage category is one of few product categories that saw positive market share growth in both the US and Canada between 2020 and 2021. This was driven by an increase in basket penetration over time.

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#cbdtea #cbdoils #cbdcures #hempproducts #hempcommunity #cbdedibles #healthylifestyle #weed #cbdflower #cbdeducation #cbdforpain #cbdtincture #thc #cbdlove #hempcbd #cbduk #cbdforanxiety #anxiety #cbdoilbenefits #cbdbeauty #cbdstore #cbdcream #natural #cbdforpets #hempheals #cbdfacts #cbdwholesale #cbdproducts #cbd #cbdhealth #cbdoil #cbdlife #cbdmovement #hemp #cbdcommunity #cbdheals #cbdwellness #cbdbenefits #cannabis #cannabiscommunity #hempoil #cbdgummies #cbdflowers #wellness #cbdhelps #health #organic #cbdshop #cannabisculture #hemplife #cannabidiol #cbdlifestyle #cbdhemp #cbdskincare #hempflower #bhfyp #mcoa #inspire #hempsmart #inspirationaltechnologies #global #IndustrialHempIndustry AFFLIATE SIGN UP REGISTRATION LINK – Opportunity to Save – Distribute – Become Knowledgeable – Change Lives #cbdoil #coa #hemp #cbdhealth #cbdproducts #cannabis #cbdlife #cannabiscommunity #cbdmovement #hempoil #cbdheals #cbdcommunity #cbdvape #thc #cbdwellness #cbdbenefits #cannabisculture #cbdgummies #cannabidiol #health #organic #wellness #cbdflowers #cbdisolate #cbdhelps #cbdshop #hemplife #cbdedibles #cbdhemp #sativa #cbdtincture #weedporn #cbdlifestyle #cbdoils #indica #cbdcures #cbdskincare #cbdflower #anxiety #fullspectrum #cbduk #ultrabroadspectrum

Posted on 02/23/202202/23/2022 by Steven M Smith — Leave a comment

Inhalers, Patches and Smart Cannabis Dosing, Oh My! RYAH Group ‘One to Watch’

RYAH Group Inc. Is ‘One to Watch’

The company is a leading developer of dose-measuring IoT devices connected with its turn-key platform designed to aggregate and correlate HIPPA-compliant data, suitable to all participants in the patient treatment cycle. The company also specializes in customized, fully integrated, mobile applications and APIs, specifically designed to meet the needs of clinics, clinical trials, government and university research centers, for experimentation and treatment validation – significantly reducing variations in patient-related trials. RYAH unlocks data in the complete therapeutic plant lifecycle – from seed to consumption.

RYAH Group is a technological leader in the plant-based treatment market with its unique combination of proprietary IoT devices and data analytics, supported by patented AI technology

The company’s products pair a growing ecosystem of therapeutic plants with top-rated apps, devices and services
RYAH offers a complete remote dosage delivery and dose-monitoring platform based on data-driven analytics supported by prescribing doctors and their patients
The company is finalizing its anticipated listing on the Canadian Securities Exchange
RYAH holds a unique position on the $100.3 billion medical plant market, with the potential to capture footholds in both the IoT and Data Intelligence industries

Since it began developing and commercializing its smart inhaler solution in 2018, the company has evolved a complete IoT device and data analytics platform that includes multiple delivery mechanisms, designed to capture anonymous patient dosing and feedback, combined with detailed strain analytics, enabling customized dosing regiments. The company has secured numerous partnerships across the globe, including establishing a footprint in the UK, USA, Australia and Canada, and it has closed several deals in the European Union, as well. The company’s Smart-Inhaler has been selected as the dose-measurement, dose-control and data analytics platform for a UK pain management study and one of the world’s most ambitious and largest clinical trials ever to be conducted in cannabis. Product Portfolio The company’s current portfolio incorporates an ecosystem of IoT products, each consisting of three elements: the device, the medicine-carrying component and the mobile application. The product line currently includes a Smart Dry-Herb Dose-Measuring Inhaler in the commercial stage, a Smart Transdermal Patch in the production stage and a Smart Liquid Dispensing Pen in the prototype stage.

RYAH Smart-Inhaler

The RYAH Inhaler is the first dry-herb inhaler that allows users to track and control how much is inhaled, providing consistent and predictable results. This inhaler connects with the RYAH Health App, which features stat-tracking and presets for temperatures and dosages, all of which can be customized to individual needs and doctor recommendations, as well as a post-session review mechanism that allows the collection of session data and feedback for further efficacy analysis for customized dosing capabilities. RYAH’s proprietary stainless-steel cartridges for the inhaler use QR technology that contains lab testing and grower information pertaining to the specific strain, thereby mitigating elicit product use and enabling completely transparent remote medicinal analytics, from seed to consumption. In addition, the RYAH Cartridges provide a unique closed-loop recurring revenue opportunity for the company, as the RYAH Inhaler only works with this type of proprietary cartridges that licensed partners fill with medicine. The partners benefit from all the back-end data, providing them access to consumption habits, statistics and other data on patient preferences.

RYAH Smart-Patch

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The RYAH Smart Transdermal Patch is a lightweight, reusable, mobile-controlled patch used for site-specific therapies. The Patch is an Electronic Topical Delivery Patch system intended for recommendation and administration by pain relief professionals and physical and occupational therapists. The patch data and the heating element is completely IoT and controlled by RYAH’s proprietary smartphone applications, which allows scheduling and ‘boosting’ medicine release, on-demand.

RYAH Smart-Pen

The RYAH Pen is an app-controlled liquid dispenser designed to provide a precise mix of up to three medicine components to create an ‘entourage effect’, enabling customized, wide-spectrum recommendation opportunities by licensed clinicians. The Smart-Pen will feature cartridges that contain CBD, THC and other isolates such as flavonoids or vitamins, or other solutions. There is a built-in mechanism designed to control usage based on recommended dosing schedules. RYAH MD RYAH MD serves as a remote and interactive patient-doctor collaboration and dosing administration platform. Doctors can remotely set dosage amounts for their patients, creating digital prescriptions for the RYAH IoT devices and tracking patient usage in real-time. RYAH MD offers features that include real-time monitoring, appointment booking, doctor-patient video calls and science-based strain recommendations, as well as promoting a better understanding of the effects and benefits of those recommendations among patients. Information is gathered from all of the RYAH devices.

PotBot App

The PotBot App is a medical cannabis education mobile application that leverages patented AI technology to capture structured and unstructured data to assist patients in learning about various treatments in plant-medicine based on their efficacy goals.

The PotBot App is currently one of the top-rated medical cannabis educational mobile applications on the Apple App Store in the United States, with over 300,000 downloads. Through the combination of peer-reviewed and empirical data, the PotBot App provides detailed information on the targeted and tested cannabinoid levels and associated strains from cannabis patients.

The result is personalized and driven by data to inform patients of potential product matches associated with similar ailments and efficacy goals.

Market Outlook RYAH holds a unique position in the $100.3 billion medical plant market, with the potential to capture and capitalize on growth opportunities made available by both the IoT and Data Intelligence sectors. In 2018, the global IoT market was valued at $212.1 billion, and it is expected to grow exponentially to $1.3 trillion by 2026, registering a CAGR of 25.68%. Management Team Dr. Boris Goldstein, Ph.D., is the founder and Chairman of RYAH Group. He is a seasoned entrepreneur, investment banker and venture capitalist. He started his career as the founder of Software House HT, which grew into a worldwide corporation with over 40 offices in 17 countries. Since then, Goldstein has founded and served on the boards of directors and advisory boards for numerous companies in Silicon Valley and Silicon Alley. Goldstein brings experience in fundamental research, investment and technology, authoring multiple patents and books. Gregory Wagner, MBA, is Chief Executive Officer and Director of RYAH Group. He has over 20 years of experience in global financial markets and entrepreneurship. Wagner has held executive roles in the United States and London. He has co-founded and built several startups from the ground up. His current licensures and degrees include FINRA Series 7, 63, 24 and 55, as well as an MBA from Fordham University. Wagner received a Certification in Innovation and Strategy from Harvard University.

TORONTO, ON February 17, 2022 / RYAH Group, Inc. is pleased to announce a collaboration with the University of Milan, Italy to conduct permeation and effectiveness testing of a new wellness line of topical patches developed by RYAH and specifically designed for the RYAH Smart Patch system.

A team of scientists at the University will be conducting various tests (1) to determine permeation effectiveness of vitamin and nutraceutical patches as an alternative slow-release, non-digested solution to consumer intake, and (2) using the RYAH Smart Patch ‘boost capability’ to monitor and calculate the effectiveness precise, intermittent heat has on the delivery of the patch loadings. The project is being led by Professor Antonella Casiraghi, PhD, Researcher and Professor in charge of formulations and pharmaceutical technology, and Professor Paola Minghetti, Head of the Faculty of Pharmacy at the University of Milan. The project will be coordinated locally by Andrea Ferrari, Head of RYAH European Business Development and based in Italy.

The global nutraceuticals market is anticipated to reach US $441.7billion by 2026 with a CAGR of 7.8%. In 2021, the United States accounted for 34.57% of the global Nutraceutical market or $104.5 billion. Nutraceuticals are significantly increasing in popularity in recent years as a result of the rise of preventative care, the COVID-19 pandemic, changes in various trends including changing lifestyles, evolving dietary habits, aging population, and increased life expectancy.

There have been a number of research papers that discuss the potential for increased permeation of certain topical formulations when exposed to a reasonable increase in heat. A 2017 paper, published in Expert Opinion on Drug Delivery, suggested heat as a possible design feature to improve transdermal drug delivery and effectiveness.

The RYAH Smart Patch is an IoT powered connected device that provides deep insights, giving consumers the ability to monitor and track their patch formulation usage, body location of patch, length of use, and personal effectiveness. The Smart Patch also offers a pre-scheduled or ad hoc ‘boost’ capability for specific formulations that may experience increased permeability with a precise, controlled, and gentle heating capability.

“We are pleased to be engaging in another meaningful research project with our partners at the University of Milan. This new project follows an ongoing, ambitious collaboration with the Department of Chemical Analysis led by Professor Gabriella Roda, with the objective to publish a scientific study on the performance of the RYAH Smart Medical inhaler. RYAH remains committed to providing effective delivery solutions combined with powerful data insights across a wide range of medicines, vitamins and nutraceuticals. The development of our wellness line combined with the RYAH Smart Patch system, is a perfect example of our commitment to keep current with important consumer trends in this expanding industry,” said Gregory Wagner, C.E.O. of RYAH Group, Inc.

Posted on 02/23/2022 by Steven M Smith — Leave a comment

Hempcrete Builds Momentum in Certification by International Building Code Council in March 2022

Las Vegas, NV, Feb. 22, 2022, The dream green building material for many building professionals may be one step closer to being certified as one of the United States’ national building materials in the US building codes, as reported that hempcrete was submitted as an appendix in the International Residential Codes (IRC) last month by the US Hemp Building Foundation.

The International Code Council experts are set to evaluate the paperwork submitted in March 2022 and then again in September 2022.

Once accepted, hempcrete will be an approved natural building material in the United States.

According to the news source, once hempcrete is approved or certified as a national building material, the material will be “accessible to the standard person to construct with” and “allow you to build with it without needing an alternative material variance.”

Certification of hempcrete will ultimately help permitting departments gain more familiarity with the material which is new to many since legalized under the 2018 Farm Bill, especially since it has a big barrier.

The barrier?

Many building professionals aren’t familiar with it or think it’s a substitution for concrete or think it’s something to get high on.

Yes, it’s a green dream to some but still unknown to others. And then there are the states that make getting a permit for hemp a bit tricky.

Since “no national guidelines, test methods or specifications for hempcrete exist” and building codes differ across the board, approval “depends on whether local officials embrace innovation”.

The US Hemp Building Association has been trying to establish “best practices and rules for acceptance” by the IRC and many are optimistic that new hempcrete codes will spark a “groundswell of interest”.

This shouldn’t be too hard with all the benefits hempcrete offers.

The insulation material “resists mold, fire and pests” and practically lasts forever.

Not to mention, it absorbs carbon.

One source noted that “hempcrete, the non-structural insulation made of hemp hurd (shiv) and lime binder, provides a superior insulation product when installed up to 1 foot thick in wall assemblies.

The material is vapor-permeable, thermally regulating, fire resistant and repels mold and pests.

Hempcrete insulation is carbon negative due to the large amounts of carbon sequestered by the hemp plant via photosynthesis while growing.

” The building industry is very “traditional” and doesn’t see many “new” materials.

Most of the materials used in the building industry have remained the same for years and those same materials have some negative environmental and health impacts.

Hempcrete, on the other hand, is not only sustainable and green, but it also makes ecological and financial sense.

It’s favorable in many ways so when the IRC enshrines hempcrete as a certified natural building material later this year, the potential for the building industry could be huge.

To date, few farmers in this country grow hemp strictly for building purposes.

It’s mostly grown for CBD, bioplastics, food, or even mulch. One generally doesn’t see it grown specifically for hempcrete.

And farmers need “reliable customers and economies of scale” and to be in close proximity to a processing center or they’ll pay exorbitant prices for shipping.

Builders that do use it now, generally can’t get enough locally so they have to import it from overseas and the quality varies.

With the industrial hemp market growing exponentially, resources and contacts are invaluable.

The industrial hemp market is expected to reach $12.01 billion by 2028

and is expected to expand at a compound annual growth rate (CAGR) of 16.2% from 2021 to 2028,

per the most recent study by Grand View Research, Inc.

In other News, Actual Hemp Houses are being built as reported by

By Jean Lotus

The professional association representing the US hemp building industry moved forward to certify hemp and lime (hempcrete) insulation in US building codes this month. Hempcrete was submitted as an appendix in the International Residential Codes on Jan. 10 by the US Hemp Building Foundation, the non-profit arm of the US Hemp Building Association.

The idea is to give U.S. building permitting departments a familiarity with the material, which is new to the United States after hemp was legalized under the 2018 Farm Bill. “These documents will show a pathway for using hempcrete as a building material,” USHBA President Jacob Waddell told Let’s Talk Hemp. “The goal is to allow you to build with hempcrete without needing an alternative material variance,” he added. An international committee of hemp building experts and advocates prepared the paperwork to submit to the International Code Council. IRC code experts will evaluate the paperwork in March and again in September to enshrine hemp + lime as an approved natural building material.

Eventually, inclusion in the IRC should “allow for hempcrete to be accessible to the standard person to construct with it,” Waddell said. Hempcrete, a non-structural insulation made of hemp hurd (shiv) and lime binder, provides a superior insulation product when installed up to 1 foot thick in wall assemblies. The material is vapor-permeable, thermally regulating, fire resistant and repels mold and pests. Hempcrete insulation is carbon negative due to the large amounts of carbon sequestered by the hemp plant via photosynthesis while growing.

Used Widely in Europe The US building industry has some catching up to do when it comes to the international use of hemp in building materials. Hempcrete has been employed as a carbon-negative insulation for 30 years in Europe, as an insulating construction material for large department stores in the United Kingdom and multistory residential buildings and public facilities in France. Patchwork of US Building Departments Right now in the United States, builders, engineers and architects who want to use hempcrete must gain approval project-by-project in the absence of an overarching national code to point to, said Texas-based developer Ray Kaderli, of the Hemp Build Network. Kaderli’s company was just permitted by the city of San Antonio to build a hempcrete-insulated three-bedroom/two-bath 1,300 sq. ft. home. Kaderli, a member of USHBA, praised the organization for moving forward with certification for hempcrete. “With a new industry there are many things to do,” Kaderli said in an email. “This was one of the most important first steps. I’m grateful [USHBA] had the insight and discipline to focus in this direction.”

The certification process also leads the way to apply to certify hempcrete in the International Building Codes for commercial buildings in 2024, when the next application process begins, USHBA president Waddell said. The material still needs to pass various ASTM fire tests as well as tests for structural bracing, Waddell said, for which the foundation will continue to raise funds. Straw Bale Builders Paved the Way USHBA hired engineering and natural building consultants, including two straw bale construction pioneers who helped get straw bale construction certified in the US residential building codes in the early 2000s. About two dozen hemp-building experts worked on the IRC submission for countless hours since October, Waddell said.

Right now, the application submitted to the IRC only includes one-story structures to be insulated with hempcrete wall assemblies without extra engineering. This is a start that will be built upon to expand hempcrete’s role in the building codes, as more data and research is submitted and approved, Waddell said. “Submitting to the IRC is just the first step in a very long process to get hempcrete where we’re able to use it more readily,” Waddell said.

The USHBA has about 200 active members and raised about $50,000 through its foundation for certification expenses and a series of other projects, including workforce development and creating educational materials, Waddell said. The organization will host a members-only online event on Saturday, Jan. 30, where more information about the IRC certification will be shared. 6,000-sq. ft Hemp Home Befuddled Permit Officials

The Massachusetts building permit official who approved one of last year’s largest hempcrete projects built on US soil last year, was initially confused at the rough inspection of the Cape Cod Hemp House, said Mary Dempsey, of Mpactful Ventures.

“The building inspector took one look and said, ‘Wait a minute, where’s your plywood?’ Then he muttered, ‘I gotta go study these plans better,’” she told Let’s Talk Hemp. Even though the Cape Cod Hemp House relied on engineering approval and didn’t have difficulty getting a permit, Dempsey said including hempcrete in the IRC codes will help local building permitting authorities better understand how it works and what it can and cannot do.

Hempcrete will figure into the construction of eco-friendly homes and buildings.

Mpactful Ventures and Dempsey helped steer the USHBA study group to gather the paperwork and research together to submit to the IRC. “People from all over the world were helping by reading this [document] to hopefully move an entire industry forward,” Dempsey said. “I’m really proud to have been part of it.” This article also appeared in HempBuild Magazine.

Is It Possible to Reach Carbon Negativity?

It is possible to reach carbon negativity — but it will take a coordinated effort to reduce emissions from their source and a significant number of offsets to get there.

One of the best ways to realistically reach carbon negativity is to employ different methods of carbon reduction to complement lowering emissions from the source. These include nature-based solutions, enhanced nature solutions, and direct air carbon capture — all of which can be done directly by companies, or through offsetting projects, which is typically easier and more verifiable.

It takes effort, a coordinated approach, and conscious investment — both of money and time — to reach true carbon negativity. But it is possible, as some major brands and corporations are proclaiming they will reach this goal as early as 2030.

How Can Companies and Individuals Reach Carbon Negative Goals?

There are many simple and practical ways for people and companies to get within striking distance of being carbon negative. From there, it is up to them to make the extra effort to achieve this status associated with offsetting more carbon than they emit.

First things first, make sure all energy used in direct operations comes from renewables or other carbon-free sources, such as nuclear. This applies to company activities that directly use energy and individual activities that use energy within the home.

Next, it is imperative to reduce indirect emissions as much as possible. For a company, this can be done by reviewing a supply chain to find suppliers and logistics that create less emissions or by limiting employee Scope 3 emissions, such as those attributable to commuting to and from work. For individuals, this can be done by making smart choices outside the home, from riding that bike to eating that locally grown food.

Lastly, after you’ve tallied up the total carbon footprint for yourself or your company, invest in more offsets than the amount of carbon emitted. It is important to ensure that the offsets you purchase are verified and of good quality, ideally with co-benefits for nature and communities in areas that they are generated. Remember: one credit typically equals 1 metric ton of carbon removed from the atmosphere — you just need to buy one more credit than tons you’ve emitted to reach carbon negative status.

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Posted on 02/20/202202/22/2022 by Steven M Smith — Leave a comment

Hemp, Nature’s “wonder crop” is in the spotlight again during the USDA Secretary’s recent tour of Lincoln University’s Dickinson Research Facility.

Las Vegas, NV, Feb. 15, 2022 Hemp, Nature’s “wonder crop” is in the spotlight again during the USDA Secretary’s recent tour of Lincoln University’s Dickinson Research Facility. reports today that hemp’s role in sustainable agriculture has garnered the attention of USDA Secretary, Tom Vilsack, as he recently announced that $1 billion in grants will be offered by the federal government to support climate-friendly farming when he toured the facility that studies agriculture.

According to the news source, grants under this program are intended to “engage agriculture, forestry and rural communities in the nation’s fight against climate change” and bolster sustainable agriculture.

What’s more climate-friendly than hemp? Environmentalists believe this “wonder crop” has the potential to make huge strides in the regenerative agriculture movement. Let’s take a look at why they believe that and how industrial hemp farming projects could see some of that $1 billion in grant money. First, hemp can improve soil health. It can be cultivated in almost any environment across the country regardless of the climate and generate high yields with a short 120-day harvest cycle (ideal for crop rotation).

Weed or wonder crop? How hemp harvests could transform the farming landscape

The self-sustaining Smartbox processes the hemp plant into high-value hemp seed oil that can be used as a biodiesel (some of which can fuel the Smartbox’s own generator), fuel pellets or livestock bedding, and hemp seed cake.

“As a cover crop, hemp restores degraded soil by blocking out the room for weeds – reducing the need for synthetic herbicides and adding diversity to crop rotations.” After harvest, hemp leaves behind biomass that can be “up-cycled into added-value products or returned to the soil, feeding essential nutrients back into the ground.”

Second, hemp supports bioremediation.

Bioremediation is when you use living things to heal and cleanse soil after years of toxic build-up. Hemp has a deep root structure and guards against weeds, naturally preparing the soil for rotation. One can liken hemp’s root structure to a vacuum cleaner – accumulating heavy metals and other toxins from the soil before it enters surrounding groundwater.

Third, hemp grows faster than trees and can “sequester large quantities of carbon dioxide back into the ground.”