Posted on 03/08/202203/08/2022 by Steven M Smith — Leave a comment

HAPPY INTERNATIONAL WOMENS DAY!

Happy International Women’s Day March 8th, 2022

In Celebration, we at Inspirational Technologies will begin a SKIN CARE SERIES for all Women And Men. After all, we need to help each other.

WHY YOU SHOULD BE USING NATURAL HEALTH SKINCARE PRODUCTS

The human skin is the first line of defense against toxins and pathogenic microorganisms. It serves important purposes in keeping our internal organs safe while making sure we are protected from the harsh nature of UV radiation and pollution. The continued exposure to these processes may end up reducing the concentration of chemicals like hyaluronic acid in the skin, thus giving way to dry skin, inflammations and other skin-related diseases.

When this happens, we turn over to skincare products for refuge.

Click to Celebrate International Women’s Day

It will interest you to note that women use an average of 168 chemicals on their body through skin care regimen daily.

The application of these chemicals is expected to keep the skin healthy as they face their daily activities.

Although some of these synthetic chemicals may prove effective in taking care of skin-related issues it is pertinent to note that they are toxic to the skin and may be carcinogenic hence the need to rely on natural ingredients for relief.

Some of the benefits of using natural health skincare products include but are not limited to the following:

a. Highly safe and reliable Most of the natural skin care products are formulated from naturally occurring chemicals with little to no side effects. Most of the raw materials or ingredients are found naturally in the skin; thus they only supplement their natural supply rather than introducing a strange chemical with potential carcinogenic properties.

b. It keeps your mind at rest With natural skin care products, no need to worry about the extra chemical or its effect on your body since it is naturally present in different concentration and applying the skin care product is only supplementing them.

c. Possess some health benefits The use of natural health skincare products offers your skin with a vast array of health benefits including hydration, wound healing, reduce inflammation, pain relief and reduced wrinkle formation. Applying these products to your skin keeps it as healthy as possible without any adverse side effect.

d. They are gentler on the skin Natural health skincare products are soft on the skin. They are not harsh, nor do they damage skin cells. Direct application of chemicals does not only damage your skin but may affect the immune system, nervous and reproductive system. Their harsh nature leaves the damages the skin while offering short term results.

e. Healthier environment Synthetic skin care products can serve as potential pollutants. These chemicals are not biodegradable and may find their ways into rivers where they increase the concentration of pollutants.

Hyaluronic acid and skin aging

The most dramatic histochemical change observed in senescent skin is the marked disappearance of epidermal HA, while HA is still present in the dermis.⁹² The reasons for this change in HA homeostasis with aging is unknown. As mentioned above, the synthesis of epidermal HA is influenced by the underlying dermis and is under separate controls from the synthesis of dermal HA.¹⁶^,⁹⁸ Progressive reduction of the size of the HA polymers in ski

n as a result of aging has also been reported.¹⁰⁹ Thus, the epidermis loses the principle molecule responsible for binding and retaining water molecules, resulting in loss of skin moisture. In the dermis, the major age-related change is the increasing avidity of HA with tissue structures with the concomitant loss of HA extractability. This parallels the progressive cross-linking of collagen and the steady loss of collagen extractability with age.¹⁶ All of the above age related phenomena contribute to the apparent dehydration, atrophy and loss of elasticity that characterizes aged skin.

Premature aging of skin is the result of repeated and extended exposure to UV radiation.¹¹⁰^,¹¹¹ Approximately 80% of facial skin aging is attributed to UV-exposure.¹¹² UV radiation damage causes initially a mild form of wound healing and is associated at first with an increase of dermal HA. As little as 5 min of UV exposure in nude mice caused enhanced deposition of HA, indicating that UV radiation induced skin damage is an extremely rapid event.¹⁶ The initial redness of the skin following exposure to UV radiation may be due to a mild edematous reaction induced by the enhanced HA deposition and histamine release. Repeated and extensive exposures to UV ultimately simulate a typical wound healing response with deposition of scarlike type I collagen, rather than the usual types I and III collagen mixture that gives skin resilience and pliability.¹⁶

In the skin, photoaging results in abnormal GAG content and distribution compared with that found in scars, or in the wound healing response, with diminished HA and increased levels of chondroitin sulfate proteoglycans.¹¹¹ In dermal fibroblasts this reduction in HA synthesis was attributed to collagen fragments, which activate α_vβ₃-integrins and in turn inhibit Rho kinase signaling and nuclear translocation of phosphoERK, resulting in reduced HAS-2 expression.¹¹³ We have recently unraveled some of the biochemical changes that may distinguish photoaging and natural aging. Using photoexposed and photoprotected human skin tissue specimens, obtained from the same patient, we have shown a significant increase in the expression of HA of lower molecular mass in photoexposed skin, as compared with photoprotected skin. This increase of degraded HA was associated with a significant decrease in the expression of HAS-1 and an increased expression of HYAL-1, -2 and -3. Furthermore, the expression of HA receptors CD44 and RHAMM was significantly downregulated in photoexposed, as compared with photoprotected skin. These findings indicate that photoexposed skin, and therefore extrinsic skin aging, is characterized by distinct homeostasis of HA.²⁹ We have also assessed photoprotected skin tissue specimens from adults and juvenile patients and observed that intrinsic skin aging was associated with a significant reduction in the content of HA and downregulation of HAS-1, HAS -2, CD44 and RHAMM.²⁸ Similar results for photoprotected skin have also been reported for both genders for HA, HAS-2 and CD44.¹¹⁴

Conclusion

The available data suggest that HA homeostasis exhibits a distinct profile in intrinsic skin aging, which is totally different of that in extrinsic skin aging. Additional insight needs to be gained in understanding the metabolism of HA in skin layers and the interactions of HA with other skin components. Such information will facilitate the ability to modulate skin moisture in a rational manner and may contribute to the refinement of current drugs and the development of novel treatments for skin aging.

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*This site receives compensation for referred sales of some or all mentioned products. We however place humanitarian value over monetary interests. Our monetary income goes back into research development discovery and healing.

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Reporting on Today’s Internal Botanical and Skin Product Benefits

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Posted on 02/23/202202/23/2022 by Steven M Smith — Leave a comment

Inhalers, Patches and Smart Cannabis Dosing, Oh My! RYAH Group ‘One to Watch’

RYAH Group Inc. Is ‘One to Watch’

The company is a leading developer of dose-measuring IoT devices connected with its turn-key platform designed to aggregate and correlate HIPPA-compliant data, suitable to all participants in the patient treatment cycle. The company also specializes in customized, fully integrated, mobile applications and APIs, specifically designed to meet the needs of clinics, clinical trials, government and university research centers, for experimentation and treatment validation – significantly reducing variations in patient-related trials. RYAH unlocks data in the complete therapeutic plant lifecycle – from seed to consumption.

RYAH Group is a technological leader in the plant-based treatment market with its unique combination of proprietary IoT devices and data analytics, supported by patented AI technology

The company’s products pair a growing ecosystem of therapeutic plants with top-rated apps, devices and services
RYAH offers a complete remote dosage delivery and dose-monitoring platform based on data-driven analytics supported by prescribing doctors and their patients
The company is finalizing its anticipated listing on the Canadian Securities Exchange
RYAH holds a unique position on the $100.3 billion medical plant market, with the potential to capture footholds in both the IoT and Data Intelligence industries

Since it began developing and commercializing its smart inhaler solution in 2018, the company has evolved a complete IoT device and data analytics platform that includes multiple delivery mechanisms, designed to capture anonymous patient dosing and feedback, combined with detailed strain analytics, enabling customized dosing regiments. The company has secured numerous partnerships across the globe, including establishing a footprint in the UK, USA, Australia and Canada, and it has closed several deals in the European Union, as well. The company’s Smart-Inhaler has been selected as the dose-measurement, dose-control and data analytics platform for a UK pain management study and one of the world’s most ambitious and largest clinical trials ever to be conducted in cannabis. Product Portfolio The company’s current portfolio incorporates an ecosystem of IoT products, each consisting of three elements: the device, the medicine-carrying component and the mobile application. The product line currently includes a Smart Dry-Herb Dose-Measuring Inhaler in the commercial stage, a Smart Transdermal Patch in the production stage and a Smart Liquid Dispensing Pen in the prototype stage.

RYAH Smart-Inhaler

The RYAH Inhaler is the first dry-herb inhaler that allows users to track and control how much is inhaled, providing consistent and predictable results. This inhaler connects with the RYAH Health App, which features stat-tracking and presets for temperatures and dosages, all of which can be customized to individual needs and doctor recommendations, as well as a post-session review mechanism that allows the collection of session data and feedback for further efficacy analysis for customized dosing capabilities. RYAH’s proprietary stainless-steel cartridges for the inhaler use QR technology that contains lab testing and grower information pertaining to the specific strain, thereby mitigating elicit product use and enabling completely transparent remote medicinal analytics, from seed to consumption. In addition, the RYAH Cartridges provide a unique closed-loop recurring revenue opportunity for the company, as the RYAH Inhaler only works with this type of proprietary cartridges that licensed partners fill with medicine. The partners benefit from all the back-end data, providing them access to consumption habits, statistics and other data on patient preferences.

RYAH Smart-Patch

The RYAH Smart Transdermal Patch is a lightweight, reusable, mobile-controlled patch used for site-specific therapies. The Patch is an Electronic Topical Delivery Patch system intended for recommendation and administration by pain relief professionals and physical and occupational therapists. The patch data and the heating element is completely IoT and controlled by RYAH’s proprietary smartphone applications, which allows scheduling and ‘boosting’ medicine release, on-demand.

RYAH Smart-Pen

The RYAH Pen is an app-controlled liquid dispenser designed to provide a precise mix of up to three medicine components to create an ‘entourage effect’, enabling customized, wide-spectrum recommendation opportunities by licensed clinicians. The Smart-Pen will feature cartridges that contain CBD, THC and other isolates such as flavonoids or vitamins, or other solutions. There is a built-in mechanism designed to control usage based on recommended dosing schedules. RYAH MD RYAH MD serves as a remote and interactive patient-doctor collaboration and dosing administration platform. Doctors can remotely set dosage amounts for their patients, creating digital prescriptions for the RYAH IoT devices and tracking patient usage in real-time. RYAH MD offers features that include real-time monitoring, appointment booking, doctor-patient video calls and science-based strain recommendations, as well as promoting a better understanding of the effects and benefits of those recommendations among patients. Information is gathered from all of the RYAH devices.

PotBot App

The PotBot App is a medical cannabis education mobile application that leverages patented AI technology to capture structured and unstructured data to assist patients in learning about various treatments in plant-medicine based on their efficacy goals.

The PotBot App is currently one of the top-rated medical cannabis educational mobile applications on the Apple App Store in the United States, with over 300,000 downloads. Through the combination of peer-reviewed and empirical data, the PotBot App provides detailed information on the targeted and tested cannabinoid levels and associated strains from cannabis patients.

The result is personalized and driven by data to inform patients of potential product matches associated with similar ailments and efficacy goals.

Market Outlook RYAH holds a unique position in the $100.3 billion medical plant market, with the potential to capture and capitalize on growth opportunities made available by both the IoT and Data Intelligence sectors. In 2018, the global IoT market was valued at $212.1 billion, and it is expected to grow exponentially to $1.3 trillion by 2026, registering a CAGR of 25.68%. Management Team Dr. Boris Goldstein, Ph.D., is the founder and Chairman of RYAH Group. He is a seasoned entrepreneur, investment banker and venture capitalist. He started his career as the founder of Software House HT, which grew into a worldwide corporation with over 40 offices in 17 countries. Since then, Goldstein has founded and served on the boards of directors and advisory boards for numerous companies in Silicon Valley and Silicon Alley. Goldstein brings experience in fundamental research, investment and technology, authoring multiple patents and books. Gregory Wagner, MBA, is Chief Executive Officer and Director of RYAH Group. He has over 20 years of experience in global financial markets and entrepreneurship. Wagner has held executive roles in the United States and London. He has co-founded and built several startups from the ground up. His current licensures and degrees include FINRA Series 7, 63, 24 and 55, as well as an MBA from Fordham University. Wagner received a Certification in Innovation and Strategy from Harvard University.

TORONTO, ON February 17, 2022 / RYAH Group, Inc. is pleased to announce a collaboration with the University of Milan, Italy to conduct permeation and effectiveness testing of a new wellness line of topical patches developed by RYAH and specifically designed for the RYAH Smart Patch system.

A team of scientists at the University will be conducting various tests (1) to determine permeation effectiveness of vitamin and nutraceutical patches as an alternative slow-release, non-digested solution to consumer intake, and (2) using the RYAH Smart Patch ‘boost capability’ to monitor and calculate the effectiveness precise, intermittent heat has on the delivery of the patch loadings. The project is being led by Professor Antonella Casiraghi, PhD, Researcher and Professor in charge of formulations and pharmaceutical technology, and Professor Paola Minghetti, Head of the Faculty of Pharmacy at the University of Milan. The project will be coordinated locally by Andrea Ferrari, Head of RYAH European Business Development and based in Italy.

The global nutraceuticals market is anticipated to reach US $441.7billion by 2026 with a CAGR of 7.8%. In 2021, the United States accounted for 34.57% of the global Nutraceutical market or $104.5 billion. Nutraceuticals are significantly increasing in popularity in recent years as a result of the rise of preventative care, the COVID-19 pandemic, changes in various trends including changing lifestyles, evolving dietary habits, aging population, and increased life expectancy.

There have been a number of research papers that discuss the potential for increased permeation of certain topical formulations when exposed to a reasonable increase in heat. A 2017 paper, published in Expert Opinion on Drug Delivery, suggested heat as a possible design feature to improve transdermal drug delivery and effectiveness.

The RYAH Smart Patch is an IoT powered connected device that provides deep insights, giving consumers the ability to monitor and track their patch formulation usage, body location of patch, length of use, and personal effectiveness. The Smart Patch also offers a pre-scheduled or ad hoc ‘boost’ capability for specific formulations that may experience increased permeability with a precise, controlled, and gentle heating capability.

“We are pleased to be engaging in another meaningful research project with our partners at the University of Milan. This new project follows an ongoing, ambitious collaboration with the Department of Chemical Analysis led by Professor Gabriella Roda, with the objective to publish a scientific study on the performance of the RYAH Smart Medical inhaler. RYAH remains committed to providing effective delivery solutions combined with powerful data insights across a wide range of medicines, vitamins and nutraceuticals. The development of our wellness line combined with the RYAH Smart Patch system, is a perfect example of our commitment to keep current with important consumer trends in this expanding industry,” said Gregory Wagner, C.E.O. of RYAH Group, Inc.

Category: Skin Care

HAPPY INTERNATIONAL WOMENS DAY!

Happy International Women’s Day March 8th, 2022

Hyaluronic acid and skin aging

Conclusion

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Inhalers, Patches and Smart Cannabis Dosing, Oh My! RYAH Group ‘One to Watch’

RYAH Group Inc. Is ‘One to Watch’

For More Information on Cannabis and CBD and YOU. Click On the Following Link

Cannabis CBD and Me

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Hyaluronic acid and skin aging

Conclusion

For More Information on Cannabis and CBD and YOU. Click On the Following Link

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RYAH Group Inc. Is ‘One to Watch’

For More Information on Cannabis and CBD and YOU. Click On the Following Link

USE PROMO CODE ” QPRBBV78NY ” (COPY & PASTE) @ E-COMMERCE WEBSITE & SAVE 15% OFF ALL ORDERS –

CLICK HERE TO BE DIRECTED TO MY SMARTCBDelivery.com Site. Free Delivery, Priority Mail in US, Same Day Packaging and Processing, 100% Happiness Guaranteed, 3rd Party Testing (COAs on Website).

AllRightsReserved2022

Share this:

For More Information on Cannabis and CBD and YOU. Click On the Following Link

USE PROMO CODE ” QPRBBV78NY ” (COPY & PASTE) @ E-COMMERCE WEBSITE & SAVE 15% OFF ALL ORDERS –

CLICK HERE TO BE DIRECTED TO MY SMARTCBDelivery.com Site. Free Delivery, Priority Mail in US, Same Day Packaging and Processing, 100% Happiness Guaranteed, 3rd Party Testing (COAs on Website).

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