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Posted on 12/02/2021 by Steven M Smith — Leave a comment

Medical Marijuana Oral Strips Being Innovative and Effective Delivery Method – Now in Canada

Sublingual marijuana strips are the answer to your prayers! As the name suggests, this product is weed in ‘strip’ form. You place it beneath the tongue, and it interacts with the absorbent membranes, better known as the oral mucosa. If you have ever used cannabis or CBD oil, you know that rule #1 is to place the drops beneath your tongue.

“Tilray’s medical brands, Aphria, Symbios, and Tilray, are relentlessly committed to investing in patient wellness through a portfolio of new innovative product offerings, GMP-certified cultivation, and the earned trust of the medical community,” Irwin D. Simon, Tilray’s chairman and CEO stated. “The launch of the Aphria-branded medical strips is a compelling proof point in this regard, and, given the growing expansion of medical cannabis across the globe, we believe we are exceptionally well-positioned in this high-growth, high-margin market moving forward.”

Medical Marijuana Oral Strips

Each Aphria medical strip is supported by QucikStrip’s proprietary technology, and it has a thin, edible film with quickly dissolving micronized cannabinoids that are absorbed directly into the bloodstream, allowing for a fast-acting and precise dosing experience offering relief from various conditions.

The strips are now available across Canada in three different cannabis ratios: THC 10, CBD 20:1, and THC: CBD 10:10 (coming soon). Each pack of Aphria oral strips comes with 30 individually wrapped strips for precise, single-dose delivery.

“At Aphria Medical, our goal is to be the trusted partner for patients by providing them with high-quality, precise, and efficacious medical cannabis treatment,” Blair MacNeil, president at Tilray Canada said in a statement. “Delivering on this mission means meeting patients ‘where they are,’ including those who are unable or reluctant to swallow medication or do not prefer the taste of cannabis oil.”

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A Question of Bioavailability

Proponents of sublingual marijuana strips point to its relatively high bioavailability rate compared to other consumption methods. The absorption rate for oral marijuana ranges between 4% and 20%. In other words, when you use a cannabis edible containing 50mg of THC, between 2mg and 10mg is absorbed into the bloodstream.

A study by Miller et al., published in Frontiers in Pharmacology in November 2018, looked at what the body does to CBD. The researchers found that bioavailability after smoking was 31%. Vaporizing weed offers an even higher absorption rate of between 34% and 56%. As for sublingual absorption, the bioavailability rate is between 12% and 35%, depending on the study you read.

Therefore, while sublingual marijuana strips ‘only’ offer you the same bioavailability rate as smoking weed, you benefit from the rapid onset of effects and no smoke! From a medical standpoint, using a strip beneath the tongue reduces exposure to carcinogens, offers a fast and powerful impact, and is very easy to do!

Medical Marijuana Oral Strips Being Innovative and Effective Delivery Method – Now in Canada Reported in Benzinga.

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Posted on 11/25/202111/25/2021 by Steven M Smith — Leave a comment

What Is Delta-8-THC?

Δ8-tetrahydrocannabinol (commonly known as Delta 8 THC) extracted from the hemp plant has been shown to have many therapeutic effects including…

What Is Delta-8-THC?

Delta-8-THC is similar to both delta-9-THC and CBD, the non-intoxicating cannabinoid. D8 shares many of the same medicinal benefits of both D9 THC and CBD.

Moreover, its intoxicating effects lie somewhere in between those of D9 THC and CBD.

Like these other more well-known cannabinoids, D8 is excellent for reducing inflammation, relieving pain, taming anxiety, preventing nausea, and much more.

But the thing about D8 THC is there’s not really enough of it to go around. While cannabis flower can consist of up to 30 percent THC and CBD, D8 THC is usually produced in quantities of less than a fraction of a percent. This difficiency of D8 makes it economically unfeasible to produce in mass quantities.

Or does it…. Interestingly, CBD can be converted to D8 THC after extraction. And CBD oils can be legally mass-produced from hemp (non-intoxicating strains of cannabis). Now you’ve got an intoxicating (albeit mildly) compound without having to grow marijuana, which, as we all know, is federally illegal.

Is Delta-8 THC Legal?

If there’s one thing the government doesn’t like it’s when people figure out ways to get around their rules. So, when D8 started becoming the new rage, the USDA decided to make it clear that all synthesized cannabinoids are Schedule I controlled substances.

So now the question becomes, what exactly does “synthesized” actually mean. And therein lies the D8 debate. While the feds say D8 is synthesized, the National Hemp Association, begs to differ. The group claims that because D8-THC is made from natural CBD, it does not qualify as “synthetically derived.”

The jury is still out on the legality of D8 and D8 still out on the open market. So far, you don’t need a medical marijuana card. You can buy delta-8 THC online. So far as we know, no one has been arrested for producing and selling D8. While it’s looking more and more likely that the federal government will either legalize or decriminalize marijuana, the question remains as to whether or not the feds will consider D8 to be a synthetic cannabinoid and choose to continue to regulate it.

. The Importance of Delta-8-THC In Medicine Aside from wielding an array of medicinal benefits, one thing that makes D8 THC so valuable as a medicine is that D8-THC is highly stable and has a long shelf life, whereas D9 THC does not. D9 oxidizes over time converting into cannabinol (CBN) which is not as medicinally useful as D8 THC.

So, the short of it is that D8 can hang around in the pharmacy or medicine cabinet a lot longer than D9 while providing many of the same benefits and lowering the risk of excessive intoxication. In various studies, D8 has emerged as a safe and effective pain reliever, anti-inflammatory, anti-anxiety, and anti-nausea treatment.

All of these claims are also made about CBD, however, D8 offers that little bit of an uplifting effect which might make it better for treating depression than CBD. One of the most promising uses of D8, however, might be as an adjunct in the treatment of cancer.

A clinical study done in 1995 explored delta-8 THC’s efficacy in reducing or preventing nausea in children diagnosed with cancer who were undergoing chemotherapy. Data showed that D8 did, indeed, safely and effectively reduced the side effects of chemo.

Many D8 users claim that it is more effective at reducing nausea than common pharmaceutical medications. We expect to see a lot more of this interesting cannabinoid compound in the future — especially in states where marijuana is legal for recreational or medical use where officials are far less likely to care about one more cannabinoid.

Legalization of hemp

The 2018 Farm Bill legalized hemp and hemp products as long as they have less than point three percent of delta-9 THC, the compound in marijuana that causes a high. But the bill doesn’t address delta-8. “It lives in that gray area,” attorney Bill Roark said.

Roark, who teaches cannabis law and regulation, said people may believe delta-8 is legal because it is derived from hemp. “I don’t think anyone can say that the intent of the Farm Bill was to find another way to create a legalized psychoactive drug,” he said. The Food and Drug Administration recently issued a warning that some delta-8 THC products can have serious health risks.

It said there have been adverse event reports in the last year involving 22 patients. They experienced vomiting, hallucinations and other issues. “You don’t know what you’re getting.

You’re getting an adulterated hemp material and so it really needs to be buyer beware,” said Dr. Kent Vrana, a pharmacologist with the Penn State College of Medicine.

When Reisinger was asked whether people are using delta-8 THC to get high, he said, “Not in our experience. I can’t say for every single person. Nine times out of 10, there’s not a psychoactive element that’s hit.

While there’s the potential, we want to be more safe than sorry.” Nineteen states have regulated, restricted or banned the sale of delta-8 THC products. Pennsylvania is not one of them.

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Posted on 11/23/2021 by Steven M Smith — Leave a comment

Cannabis Global Expands into Solventless Cannabis Extracts at Lynwood Facility

LOS ANGELES, CA – November 23, 2021 Cannabis Global, Inc,. an innovation-oriented company investing in disruptive cannabis technologies, today announces an important enhancement to its cannabis product manufacturing capabilities at its Natural Plant Extract of California facility in Lynwood, a suburb of Los Angeles. The facility is now producing solventless cannabis concentrates for use in its own cannabis products, including edibles, beverages and pre-rolls.

Cannabis Global

Most of the cannabis extract products on the market are prepared using solvents such as butane, propane, and carbon dioxide to extract the oils and cannabinoids from the plant.

These products ultimately have most of the solvents removed, but the taste profile of the original plant material is altered in the overall process. The solvent-less extraction methods used by the Company instead rely 100% on water, ice, heat and pressure to extract the desirable components from the cannabis plant .

“Consumers are increasingly turning to solvent-less products for three reasons: purity, taste and experience,” commented Arman Tabatabaei, CEO of the Company. “We do not have to remove the chemical solvents from these products as none are ever added. It’s just water, heat and pressure. Many consumers prefer the natural taste of solvent-less produced extracts and believe such products offer a superior user experience. We expect continued growth in the marketplace as consumers increasingly gravitate toward these high-quality products.

“Solvent-less operations at the Company’s Natural Plant Extract of California facility include both ice water hash production, which uses water and ice to separate the valuable trichomes from the plant materials, and rosin production, which uses heat and pressure to produce an ultra-premium concentrate.

The Company plans to utilize these solventless concentrates to enhance cannabis products, such as premium pre-rolls, edibles and beverages, which are in various stages of availability and pre-production.

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Posted on 11/17/202111/17/2021 by Steven M Smith — Leave a comment

Dipping From The Same Pot. Federal Legalization Of Cannabis Will Shake Up Florida Structure

Florida is a fully vertically integrated state, and this has had some pretty massive impact on the way the legal cannabis market has grown in the state.

Florida, long thought known to have a Medical marijuana policy which would make sense have instead, implemented a system in which all cannabis companies are their own grower, processor, and distribution channels under one corporate entity with zero allowance for cooperation or subcontracting outside of some very special cases of outside products being licensed for production with one of the currently licensed Medical Marijuana Treatment Centers (MMTC, Florida’s term for these vertical cannabis companies).

Evidence of the system’s shortcomings can be found in a number of places and has permeated every corner of the “green rush” here.

Licensing – The first place to look for a clue as to the effects of a government-forced cartel system is in the market itself, based on the numbers available from the Florida Office of Medical Marijuana Use.

The numbers tell us two different stories: one of a stifled market with little incentive for innovation or growth, and one of an industry held back by regulations.

When looking at the effects vertical integration has had on the market itself, the most glaring thing is the limited number of licenses.

Florida started with only eight licenses, then approved four more, then another four, and eventually culminating in the 22 currently licensed operators.

Of those 22, only 13 are currently producing and dispensing products.

This is nearly four years after 71.3% of Floridians voted for Amendment 2, legalizing medical cannabis here in the Sunshine State.

This is fewer license operators than states significantly smaller, and newer to the legal market.

Vertical Integration has created a government-regulated monopoly virtually free from competition, entrepreneurship, and many of the jobs and opportunities normally associated with a growing industry.

Brian Vicente of Vicente Sederberg LLC said in an interview for Cannabis Business Times, “By mandating that anyone that’s allowed to do either of those activities needs to own both, you’re basically limiting yourself to rich people that can enter the market. I think that’s a negative thing in terms of promoting economic and racial diversity in this new industry.”

The point was further evidenced with the original licensure requirement of 30 years in business as a commercial nursery, which has since been ruled unconstitutional.

Product availability –

The second major effect that can be seen from these numbers is the lack of product availability and the slow rollout of normally available delivery methods.

Recreational Delivery Companies in Most States Deliver From A Local Dispensary.

Federal Legalization will allow delivery from Cannabis Depots where shipments

will be tracked into Depots from around the country.

See our post on ComplyBag Technologies

Florida started with only CBD available. When dispensaries first began opening a few months later they could only sell CBD over the counter and had to sell THC by delivery only.

For the first three years of legalization, Floridians were only allowed concentrates and tinctures. It took a lawsuit from Cathy Jordan to get Floridians the right to use whole flower cannabis, which also led to a near doubling of the market.

In case it didn’t jump out immediately, yes that said Florida was legal for three years before whole flower medication was available, and further cements the first downside by being the largest and most blatant constraint on the industry.

The industry was effectively kept at 50% of its capacity for the first three years.

Florida still has edibles only for those who seek Medical Approval for this delivery method and even faced a push this year by state legislator Gayle Harrell to cap cannabis products at 10% total THC.

As Of September 2, 2021

Limitations of vertical integration Outside of the industry in nearly every state. Cannabis titan MedMen has been one of the most successful marijuana firms to date, pushing the vertical integration model for the last several years.

In the last 18 months though, they have been among the hardest hit by a trend of market corrections, culminating in Interim CEO Ryan Lissack telling CNN that, “While vertical integration has been a big focus in the industry, our growing belief is that cannabis is evolving like every other consumer vertical: with a fragmented value chain and specialists at each layer.”

As other states are legalizing cannabis for medical and adult-use purposes across the country, Florida is still dragging its feet on things that should be a given when discussing medical marijuana.

As the major players nationally, and internationally, are moving away from the large mega-corporations and vertical operations, Floridians are still stuck with limited product options from a state-mandated oligopoly.

While there is nothing wrong with successful businesses diversifying into other segments of the supply chain, the evidence suggests that forcing this model onto the industry at large creates a stifled industry that lacks competition, small businesses, and the need for innovation. Specialization is the future, and it’s currently the one thing Florida lacks.

While the National Legalization undergoes it own legalization pains, we must look to states that have “moved the chains of aftermarket legalization”. In California, movement of cannabis products in the State and Subsequent Move to outlying areas are being utilized to help satisfy the recreational market. We in the USA who are interested, involved, curious and betting on the right way to proceed, need to take a step back and LOOK at The Bigger Picture.

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Posted on 11/14/202111/14/2021 by Steven M Smith — Leave a comment

President Joe Biden Announced Friday Intention To Nominate Dr Califf as Food and Drug Administration (FDA) Commissioner, Who Once Prescribed Marijuana

President Joe Biden announced on Friday that he intends to nominate a new Food and Drug Administration (FDA) commissioner who has acknowledged the potential medical benefits of marijuana and says he actually prescribed a cannabinoid drug as a doctor.

Dr. Robert Califf, who previously served a short stint as the FDA head under the Obama administration, hasn’t been especially vocal about marijuana issues.

But at a 2016 federally hosted research summit on cannabis, he recognized various therapeutic applications for the plant and its components and emphasized that the agency is interested in promoting research and development. “We understand that people have identified a number of possible uses of marijuana and marijuana-derived products. For example, AIDS wasting, epilepsy, neuropathic pain, treatment of spasticity associated with multiple sclerosis, cancer and chemotherapy-induced nausea,” Dr. Califf said.

“And I had the chance to prescribe some of this in my cardiology practice in people with extreme heart failure who get a wasting cachectic syndrome.” Notably, he also said that while FDA had yet to find that botanical marijuana is “safe and effective for any indication,” that’s not to say there aren’t any good uses for it, and additional studies could shed light on the situation.

FDA’s position on cannabis is “not because we’ve had a ton of applications to look at,” he pointed out. “It’s because we haven’t gotten them into the pathway,” Califf said. “What this means is that no one has demonstrated to FDA that any such product is safe or effective for the treatment of any disease or condition. To change that we need studies conducted using marijuana to rigorously assess the safety and effectiveness of marijuana for medical use.”

“Then we need to get those studies submitted to FDA and a marketing application for review under the legal standard set out in the federal Drug and Cosmetic Act,” he said.

“This assures that the drug product meets the statutory standards for approval.” “This is what we really want and we actively encourage it and want to work with people to make this happen,” he added.

“To do this, we know we need to facilitate the work of companies interested in appropriately bringing safe, effective and quality products to market, including scientifically based research concerning these medicinal uses.”

“We believe this process, which includes collaboration with other federal and state agencies, researchers and manufacturers working on issues related to the use of cannabidiol and other constituents of marijuana in the U.S. remains the best way to identify new treatments that are safe and effective for patients and to protect patients from products that are not what they purport to be.”

At the summit, Califf also noted that FDA has approved synthetic cannabis products like Marinol for the treatment of anorexia associated with AIDS and nausea related to chemotherapy treatment.

The approval of these substances “supports the point I made earlier that our decisions on the approval of any medicine relies on the science to determine the safety and effectiveness of new medicines. And it’s also consistent with the approach we’ll continue to take going forward in this area,” he said.

Overall, the remarks suggest that, if confirmed, it doesn’t seem that Califf wouldn’t be hostile toward attempts to explore the therapeutic potential of cannabis. But he does seem to defer to statutory processes within FDA that favor pharmaceutical approaches to these medicines that have so far kept marijuana in a tightly regulated drug category.

Separately, some vaping stakeholders have raised concerns about the prospective nominee, pointing to a 2019 op-ed he authored that advocated for a ban on flavored vape products as a way to mitigate the risks of the e-cigarette or vaping use-associated lung injury (EVALI) crisis.

“I believe that we should move to enact strict regulation to limit the harm done by vaping products, augmented by an aggressive public education program that is particularly aimed at vulnerable young people, but not excluding adults,” Dr. Califf wrote at the time.

However, he acknowledged that an “outright prohibition of vaping products seems impracticable on several grounds,” adding that the “regime of legal prohibition also dissuades people from seeking help with addiction for fear of stigma that might negatively affect future employment and social mobility.”

I f Califf does become commissioner, he’ll have his work cut out for him on the cannabis front.

For example, industry stakeholders are eagerly awaiting action by the FDA to allow CBD to be marketed as a food item or dietary supplement.

T he agency has said that it is exploring regulatory pathways to allow for such cannabidiol commerce, but bipartisan lawmakers have introduced legislation this session to force a change.

FDA was mandated under appropriations legislation enacted in 2019 to provide an update on its regulatory approach to CBD, and it did so in March of last year.

The update stated that “FDA is currently evaluating issuance of a risk-based enforcement policy that would provide greater transparency and clarity regarding factors FDA intends to take into account in prioritizing enforcement decisions.”

A nother issue that FDA is focusing on concerns delta-8 THC products that are made through a synthetic process using hemp-derived CBD.

The agency issued warnings to consumers about the potential risks of the cannabinoid in September.

FDA also recently announced that it plans to use Reddit and other “novel” data sources to gain a better understanding of public health issues surrounding use of CBD and other “emerging” marijuana derivatives like delta-8 THC.

With respect to broader marijuana policy, FDA would play a critical role in any moves to reschedule or deschedule cannabis.

If a scheduling petition is accepted, the agency would need to assess the scientific, medical and public health implications before submitting that review to the Justice Department with its recommendations.

FDA Acting Commissioner Janet Woodcock, meanwhile, frustrated advocates earlier this year after dodging a congressman’s question about whether marijuana is more harmful than tobacco.

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Posted on 11/10/202111/10/2021 by Steven M Smith — 1 Comment

Cannabis Global in Distribution and Purchase Option Agreement for Cannabis Transport System Comply Bag(R)

LOS ANGELES, CA November 10, 2021 Cannabis Global, Inc. , an innovation-oriented company investing in disruptive cannabis technologies, today announces it has entered into a distribution agreement with Humboldt Bliss to distribute the Company’s Comply Bag®, cannabis transport system with integrated smartphone track and trace app.

Cannabis Global

As part of the agreement, the Company also also granted Humboldt Bliss an option to purchase a controlling interest in Ethos Technology LLC, dba Comply Bag®, a wholly-owned subsidiary of Cannabis Global, for $4 million, which controls the products and the associated intellectual property.

David Welch, the managing partner at DRWelch, a Los Angeles-based law firm specializing in regulatory compliance and intellectual property issues with a strong specialization in the cannabis industry, who serves as general counsel of Humboldt Bliss, commented, “We see strong possibilities relative to Comply Bag® especially relating to what most people in the cannabis industry believe will be an upcoming national market for cannabis. Comply Bag® is the best way to stop diversion of cannabis from the legal market into the illicit market and we believe likely to become a standard requirement for Government approved cannabis facilities. As more licensed and legal cannabis commerce occurs, the secure tracking and tracing of cannabis shipments will become a vital interest of both corporations and regulatory agencies.”

Comply Bag® utilizes proven security, tamper resistance, and tracking

features that will allow cannabis companies to transport products

as safely as large financial institutions transport cash and marketable securities.

The product includes the integration of the METRC applications programming interface (API)

into a custom smartphone app that will allow cannabis shippers and receivers to scan shipments

with the information being integrated directly into the leading cannabis track and trace system.

At least 15 states, including California. #CannabisGlobal

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