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A Quick Guide to the Psychedelic Mushroom Boom

The majority of the psychedelics community has rarely made contact with the world of venture capital and high-growth startups.

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This is dangerous because it doesn’t allow for those that work with psychedelic substances to understand what the next 10 years will bring their way… and as of right now the future doesn’t look too bright.

A Venture Capital (VC) firm, is in its simplest form just an entity that invests the money of rich folks into the companies that it believes will become the most financially valuable. There are of course other considerations for some investing groups such as: patient outcomes, environmental impact and sustainability, and general ESG methodologies. But for the most part VC firms work to provide a , financial gain,to their investors by providing cash to startups that want to grow their business fast.

Let’s say that you are a psychotherapist who’s been running their own clinic for a few years. You were trained by MAPS to do psychedelic assisted therapy and have incorporated the service into your practice. Business is booming. Everyone wants access to your transformative care.

Perhaps you want to open up a second clinic where you can hire on some more therapists with the proper training, but you don’t have the money saved up yet to open up another location.

You could wait a few years, go to a bank to get a loan, or you could seek out an investment.

If you choose to go raise money for your venture you’ll be met with a lot of questions most of which will be pointed at one thing: scale. Most investors won’t put down capital for you to just open up one additional clinic. You’ll need to describe a vision of growing fast and scaling your brand to be the most impactful, widely distributed clinic on the planet.

Why? Because investors lose money on most investments that they make. Almost all of their returns are made from the few investments that knock it out of the park. The billion dollar unicorn that can grow their money more than 100x.

None of this is to say that good companies that can generate a high return don’t exist, but it’s very difficult to find that balance. Within our current system, companies need to compete with one another. That competition plays out through cutting costs, moving quickly, and oftentimes deprioritizing people, the environment, and quality.

It’s also very difficult to prioritize long term results. Every VC firm collects a new pool of money every few years called a . Most funds only run for 7 years, 10 years on the long end. Within 10 years you need to see a company sold off or going public for you to cash out and see the fruits of your investment. A company that has a 25 year mission to revolutionize patient care, but has to suffer losses for the first 10? Not going to happen.

As I mentioned earlier, there are strategies for forming firms around values, impact, and longer term results. But it’s extremely difficult. A firm can focus on investing in B Corps, but B Corp status is very time and resource intensive to pursue. There are a few companies in the space that have done it including MAPS and The Third Wave, but it’ll be a long road before we see a meaningful percentage of psychedelics companies adopt this style of doing business.

All of us from Auryn Fund, to Field Trip, to our own Tabula Rasa Ventures are trying hard to make sure that the future of this industry reflects the incredible community that’s built it. But we need to be having more open conversations along with detailed strategies for how to do investment right.

If you read the PALA story.

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Quick Guide to Psychedelic Startups

How to Raise Capital for a Psychedelic Startup: Industry Info You Need to Know

In the recent past, psychedelics were considered dangerous drugs. Today, more and more scientists recognize their medical potential. Investors are already investing in the young industry.

Psychedelic drugs have a complicated history. They had a heyday in the 1960s but then fell into disuse. Recent research has partially brought psychedelics back. Today, scientists see them as promising compounds for treating many diseases.

Given the above, it is quite fair to say that the era of the so-called psychedelic renaissance has begun. Since 2020, the number of psychedelic companies has started to increase greatly.

Let’s take a look at the reasons for the increased demand in the psychedelic industry. Learn how to raise capital dealing with this type of business.

Psychedelics Boom

Despite Covid-19 and the collapse of the economy, investors are starting to pay attention to this industry. They bet that psychedelic-derived drugs can become a real business and help millions of people. Researchers, activists, and journalists have been the driving force behind the psychedelic renaissance.

Benefits of Psychedelics

Many startup companies are developing drugs based on psilocybin (the active ingredient in magic mushrooms), LSD, MDMA, and ibogaine. They are banned in the United States, except ketamine, which is also used in the development of such medicine. These companies hope to develop a psychedelic therapy treatment for a wide range of mental illnesses. They include depression, anxiety, addiction, and post-traumatic stress disorder (PTSD).

Medical regulators are also gradually turning toward psychedelics, as they show potential in treating depression. In 2019, the Food and Drug Administration (FDA) called Usona Institute’s psilocybin program for major depressive disorder “breakthrough therapy.”

However, researchers will have a tough road to winning FDA approval.

How Medical Companies Turned to Psychedelics

In early 2020, the drug company Mind Medicine (MMEDF) went public. It received the financial backing of Kevin O’Leary and the guidance of cannabis entrepreneur Bruce Linton. In one interview, O’Leary explained his reasons for investing in psychedelics and talked about the lagging efforts to treat growing psychiatric disorders.

In 2013, Linton became a co-founder of Canopy Growth (CGC), the largest cannabis company in the U.S. He left in 2019 and later became director of Mind Medicine. The main goal of the company is similar to Compass Pathways. They plan to bring psychedelics to market and conduct research on LSD, mushrooms, and other drugs.

Investing in Psychedelics

Venture capital investors were at the centre of the psychedelic boom. In early 2020, startups in the field said they were beginning to see signs of growing investor appetite.

Venture capital firms focused on psychedelic companies soon began to appear. Insider’s list of the top 11 venture capitalists in the field shows $139.8 million invested in such startups in just a few years.

Kevin O’Leary and PayPal co-founder Peter Thiel make big bets on magic mushrooms. Their big plans for mind-altering mushrooms have nothing to do with festivals or raves but deal with biotech instead.

Negev Capital, a psychedelic medical intervention investment fund, invests in companies that are developing new drugs to treat mental disorders based on psychedelic compounds. Negev has invested in 20 psychedelic drug development companies and has more than $30mln under the management

The fund recently doubled down on its substantial investment in Small Pharma Inc, a neuropharmaceutical company specialising in developing new treatments for mental illness with a focus on depression.

Another representative of psychedelic medicine is ATAI Life Sciences. It’s a “drug discovery platform” from Germany. The company invests in research of possible uses of psychedelics and other drugs for medical purposes. As of January 2021, they had raised more than $210 million, much of it from Thiel Capital and Christian Angermayer.

ATAI Life Sciences has taken a majority stake in Recognify, which was founded by Thomas Südhof, winner of the 2013 Nobel Prize in Physiology and Medicine. Recognify’s aim is to develop drugs to help treat schizophrenia. The company focuses on cognitive impairments (CIAS) that interfere with verbal learning and memory. Their new drug, RL-007, although not derived from psychoactive compounds, has already undergone positive clinical trials.

Atai Life Sciences Goes Public; Now the Largest Publicly Traded ...

Another company is Compass Pathways (CMPS), which went public in the United States back in September 2020. The British company, invested in by Thiel and Angermayer, has patented a synthetic form of psilocybin. It helps people with treatment-resistant depression.

The company launched clinical trials that involved 233 patients at several sites across Europe and North America. It is the most rigorous trial on psilocybin, which adds great weight to previous, smaller studies of the drug. In November 2018, FDA called the company’s treatment “breakthrough therapy.” This means the approval may come soon if trials are successful. Compass will start Phase 3 trials in the near future.

Cybin is a biotech company focused on the development of psychedelic therapeutics. In October 2021, it completed its 74th pre-clinical study of psychedelic compounds for potential therapeutic applications in several psychiatric disorders. Over 50 new compounds have been evaluated with the help of experienced contract research organizations.

Image result for Cybin is a biotech company focused on the development of psychedelic therapeutics. In October 2021,

The company seeks to build a portfolio of world-class psychedelic molecules that could become commercially viable drug candidates for both internal development and future partnerships.

The current psychedelic boom is only the beginning of the industry’s development and expansion. Considering investors’ attention to this type of medicine, more startups will emerge in the future. Active research on psychedelics has resumed in recent years, after its peak in the 1950s and 1970s. It may lead to great scientific progress and heal millions of people.

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Many startup companies are developing drugs based on psilocybin (the active ingredient in magic mushrooms), LSD, MDMA, and ibogaine. They are banned in the United States, except ketamine, which is also used in the development of such medicine. These companies hope to develop a psychedelic therapy treatment for a wide range of mental illnesses. They include depression, anxiety, addiction, and post-traumatic stress disorder (PTSD).

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Marijuana Companies laying off hundreds of workers, deemed “essential”.

Marijuana companies lay off hundreds, retrench amid economic woes

Women, minority execs show few gains in U.S. cannabis industry, according to the latest data from the MJBiz Diversity, Inclusion and Equity Report.


Image depicting economic woes, layoffs, recession

While business around the world shuttered as COVID-19 spread, the marijuana industry was deemed “essential” in nearly 30 states and stood to gain from the pandemic.

But more than two years later, amid rising inflation and fears of a recession, North American cannabis companies are cutting hundreds of jobs, closing retail outlets and cultivation facilities or shuttering altogether.

The marijuana industry mirrors mainstream companies that saw similar demand and now are struggling to right-size their businesses.

Sales of Peloton bikes spiked when gyms closed and people sought fitness alternatives; but the New York-based company has axed more than 4,000 jobs so far this year.

The pandemic-era e-commerce boom that boosted Shopify’s business also appears to have cooled, and the Canadian company, which makes the technology that powers online stores, has laid off about 1,000 workers.

The cannabis industry layoffs and retrenchment have affected plant-touching companies large and small as well as tech businesses such as Akerna of Colorado, Dutchie of Oregon and delivery operator Eaze of California.

The factors behind the cannabis retrenchment are numerous. They include falling wholesale marijuana prices, cash-strapped consumers and structural changes affecting the industry, experts said.

Among the more notable plant-touching companies that have been caught up in the fallout in recent months:

  • California-based cannabis advertising giant Weedmaps cut 10% of its roughly 600-member workforce, citing market contractions in California, Colorado and Oklahoma.
  • Arizona medical marijuana grower Nature AZ Medicine laid off around 100 employees as medical sales drop and recreational sales spike.
  • Michigan-based Lume Cannabis closed four of its roughly 30 stores in the state but did say it plans to open three additional stores in more populated areas. The realignment, disclosed in July, comes at a time when marijuana prices in Michigan have tumbled because of market saturation.

Corporate turnarounds

In addition to inflation and economic woes, cannabis businesses are grappling with staffing issues.

For one, many public marijuana companies are undergoing turnarounds, which often translate into the shedding of employees.

“The guys who come in to handle turnarounds don’t understand the market and cannabis,” said Avis Bulbulyan, CEO of Siva Enterprises, a California-based marijuana consulting firm.

Edmonton, Alberta-based Aurora Cannabis said in June that it was cutting 12% of its workforce as part of a corporate restructuring.

The company expects the move will save up to 90 million Canadian dollars ($69 million) and put it on the path to profitability. The company’s goal is to turn its first profit next year.

Another Canadian public company, Canopy Growth Corp., disclosed in August it cut 245 employees – or about 8% of its workforce – as part of sweeping changes across the company designed to help stem recent losses and nudge the struggling producer to profitability.

Canopy said it expected the cuts and adjustments to generate up to CA$150 million in savings in 12-18 months.

Canopy also closed its cultivation facilities on 23 acres in Niagara-on-the-Lake, Ontario, last year.

Echoes of the dairy industry

“The legal cannabis business is volatile,” said Daniel Sumner, professor of agricultural and resource economics at the University of California, Davis and co-author of “Can Legal Weed Win? The Blunt Realities of Cannabis Economics.”

“It’s a new industry,” he said, “and companies are coming and going and being acquired in all parts of the industry – not just growing and processing and selling.”

Consolidation in the marijuana industry is similar to what happened to Wisconsin’s dairy industry, which lost 10% of its farms in 2019 and 44% over the past 10 years.

“Production went way up, but the number of farms went way down,” Sumner said. “It’s consolidation. A lot of that consolidation means if you’re a manager, you call it labor-saving efficiencies.

“But if you’re a worker, you lost your job.”

Despite the cost of other products rising because of inflation, the price of marijuana has declined, another factor impacting companies’ ability to retain employees.

In Colorado, for example, the wholesale price per pound of marijuana was $709 as of July 1 – an all-time low – and down 46% from $1,309 a year ago and nearly 60% from $1,721 in January 2021, according to Colorado Department of Revenue data.

“Farm-level cannabis costs coming down is the reality of this business,” Sumner said. “It’s partly improved management; some is technology.”

But, Sumner said, like other agricultural crops, price declines in the marijuana industry should be expected.

“Adjusting for inflation, we now spend 10% of our income on food – not 4% like we did two generations ago – and there’s no reason to think cannabis won’t follow that trajectory.”

 Structural changes

And just as practices shifted from a customer-focused approach at grocery and liquor stores where someone would tell you about the products, practices at cannabis retail stores also are likely to see changes that result in the need for fewer employees.

“Everybody used to buy their beef or their fish from the person who really knew beef and fish – you walked in and talked to the baker, the butcher or the fish monger about what you want,” Sumner said.

“That’s the way it’s handled in cannabis now. But cannabis is moving away from it. It will be cheaper and more available, but there won’t be the services and employment.”

Like other industries, venture capital funding also has become scarce for cannabis businesses seeking investors to fuel their growth.

Without financing, it’s tough to keep as many employees as possible on staff, said Karson Humiston, founder and CEO of Denver-based cannabis recruiting network Vangst.

“People are really tightening the belt and working to preserve cash because funding is hard to come by,” Humiston said.

“When companies have a harder time raising capital, they need to make sure they have enough cash to weather the storm. The first thing to go is expensive headcount.”

The majority of job cuts are at the senior level – not hourly employees who work in grows or retail shops, Humiston said.

And with many multistate operators using more gig employees than in the past, Vangst is having its busiest summer ever.

“People are still purchasing and consuming cannabis, so these hourly workers are essential,” she said.

“Cannabis still needs to be grown, packaged and delivered to customers. Those are hourly roles.”

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When US Farmers heard that President Trump had legalized the cultivation of hemp across the US just before Christmas, one Colorado farmer immediately thought: “Oh boy, here we go! Things are going to move very fast.”

That Colorado farmer tends to about 15 acres (six hectares) of hemp, the species of the cannabis plant that doesn’t have any psychotropic effect – it cannot be used to make a person “high”.

Hemp, or cannabis sativa, to give it its Latin name, is the straitlaced cousin of cannabis indica, which is better known as marijuana.

Hemp – It’s Last 50 Years United States Story in Brief !

1 – Unfortunately for hemp, being a near-relative and lookalike of marijuana has meant that it has always been tarnished by association.

2 – So while hemp is a very useful crop that can be turned into everything from clothes to shoes, paper, animal feed and building insulation, the cultivation of it was banned in many countries during the 20th Century.

3 – In the US it was outlawed in 1970 by President Richard Nixon, and that remained the case until December last year, when the Agriculture Improvement Act of 2018 was passed into law.

4 – Hemp farmers now expect US production to skyrocket, and industry estimates back that up.

5 – New Frontier Data expects US sales of hemp products to reach $2.6 Billion by 2022. At the same time it predicts Global hemp industry sales to jump to $5.7 Billion by 2020, from $3.7 Billion in 2018.

6 – The chemical compound in marijuana that makes a user high is called tetrahydrocannabinol or THC. Hemp contains a trace amount of THC, but not enough to make a person high

7 – While hemp can now be grown legally across the US without a licence, marijuana can be cultivated only in about half the states, often only under licence and solely for medical use

8 – Hemp farming has a long history in the US, with first President George Washington growing the crop

9 – Hemp can grow up to 20ft or six metres high, twice as tall as marijuana

10 – You need to become involved, NOW.

“Soaring demand worldwide for a key chemical compound called cannabidiol or CBD, which is found in the flowers of the hemp plant, is behind the growth.”

“CBD – which is also present in marijuana, but does not make the user high – helps to treat epilepsy. As such it is used to make epidiolex, an anti-epilepsy drug that is now prescribed in both the US, and by the National Health Service in the UK.”

“Once more consumers get educated about CBD, that’ll drive more demand,” says Elliot Brown, another Colorado hemp farmer.

Mike Lewis, a hemp farmer in Kentucky, agrees that CBD production is now going to lead the hemp industry as opposed to the crop’s industrial uses.

“Everyone in the hemp industry is turning to CBD because that’s where the money is,” he says.

Whether CBD and products containing it actually do have widespread health benefits, or could in fact harm you over the longer term, is still being debated in the medical community, as the Guardian newspaper reported last year.

In the meantime the boom in demand for hemp is good news for the US environment because the fast-growing and hardy plant needs very little water, and therefore requires far less irrigation than corn, wheat or soybeans in dry areas.

Hemp plants can also be planted very close together, making it high yielding. And unlike marijuana, whose plants are half as tall and have bigger leaves, hemp isn’t fussy about temperature and humidity.China is currently the world’s largest exporter of hemp products, but the US industry wants to change that.

“At some point we’ll see American hemp production eclipse China,” says Bob Hoban, a commercial lawyer who represents growers of both types of cannabis across the US.”We’re already seeing a massive investment in production infrastructure, and that takes time. We’ll eventually reach the point where hemp will not just appeal to the cannabis industry and their consumers.”

However, Erica Stark, executive director of the National Hemp Association, cautions that the industry needs to walk before it can run.

Last year just 78,176 acres of land in the US was planted with hemp, compared with 47 million acres dedicated to wheat, and 90 million acres to both soybeans and corn. “The danger we’re facing now is over-enthusiasm,” says Ms Stark. “We just don’t have the infrastructure to go into full commercial production. Yet.”

Farmers in Florida are now planting their first crops in Broward- Dade counties in south Florida and have high expectations for the state’s economic growth. We at HempSMART, are excited for the opportunity to deliver to you in the United States, a Premium CBD (THC Free) product line that is 100% Legal with a 30 Day happiness guaranteed satisfaction. Click on this statement to be linked to our website and order our products or Join Us to become involved in a great opportunity. Thank you so much for your time and consideration.

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Latest News On CBD

FDA still not sure of CBD. See upcoming Post on their agenda to take public statements, ends July 2nd.

To Be Continued