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Cannabis and the Endocannabinoid System: The Wonders of CBDs

 

Cannabis and the Endocannabinoid System: The Wonders of CBDs

Updated with PAiNT Research Palette – Green

Co-edited by Steven Smith, PAiNT Research   Mature Hemp Field Crop Hemp Is Now A Viable Agriculture Phenomenon Cannabis and the Endocannabinoid System; The Wonders of CBDs CBD Molecule The following is a reprint with updated references. Cannabinoids are the chemical compounds made by the cannabis plant that unlock its many healing secrets. There are over 100 known cannabinoids and these chemicals imitate the endocannabinoids naturally produced in the human body. The shiny little crystals you see on cannabis buds are called trichomes where cannabinoids are stored. Human bodies (and many animals) have endocannabinoid systems (ECS), meaning that cannabinoids are naturally made so they can bind to endocannabinoid receptors creating changes in our physiology. To understand the master gland and immune system of the human body it is crucial to have a basic understanding of the endogenous cannabinoid system, otherwise known as the endocannabinoid system (ECS). The endocannabinoid system is essential to human health because it maintains homeostasis in the body. Research into the endocannabinoid system has increased in recent years as scientists begin to reveal how complex and important this system is to our bodies. The legal cannabis movement started in San Francisco in the early 1990’s when it was discovered that cannabis treated many symptoms that AIDS patients suffered from, including pain. It was medical marijuana laws that changed the legal status of cannabis nationwide, opening the doors for research and an adult-use market and creating a path towards full legalization. Cannabis patients across the country have used the plant to treat a growing number of medical conditions. In Colorado alone, there are nine different qualifying conditions for a medical card: cancer, glaucoma, HIV or AIDS, cachexia (wasting syndrome), persistent muscle spasms, seizures, severe nausea, severe pain, and Post Traumatic Stress Disorder (PTSD).

  What Do CBD’s Do? The endocannabinoid system (ECS) is responsible for maintaining homeostasis in the body. Homeostasis is defined as: “any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival.” If homeostasis is successful, life continues; if unsuccessful, disaster and ill health ensues. The endocannabinoid system is made up of three parts: cannabinoid receptors, endocannabinoids, and metabolic enzymes.   • Endocannabinoid receptors are found throughout the body on the surface of cells in the brain, organs, tissues, and glands. These receptors are embedded in cell membranes and produce varying reactions when stimulated by cannabinoids. • Cannabinoids come from two distinct places — the body, which produces naturally occurring endocannabinoids, and foods like the cannabis plant, which produces phytocannabinoids. • Metabolic enzymes act like a natural referee in that they destroy endocannabinoids once they are used up by the body. The two main metabolic enzymes are fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). This self-regulating system ensures the interaction of CBDs with the ECS only happens when needed and therefore keeps the workings of the endocannabinoid system relatively quiet to the conscious brain. Because homeostasis is so important to health, all vertebrates and invertebrates are known to have an endocannabinoid system.

  Cannabinoids can also be produced synthetically. Marinol (dronabinol) and Cesamet (nabilone) are synthetic versions of THC that have FDA approval to be marketed and sold as a prescription drug. Synthetic cannabinoids do unlock the endocannabinoid system to produce effects, but they often fail to incorporate the entourage effect which states that the sum of the different cannabinoids works better as a whole unit than any cannabinoid individually. With an understanding of the endocannabinoid system and its role in ensuring homeostasis in the body, it may be easier to see how this could be true. The Endocannabinoid System Despite its critical importance, the endocannabinoid system (ECS) was only discovered in the early 1990s when Lisa Matsuda, a researcher at the National Institute of Mental Health, and her colleagues discovered a DNA sequence that defines a THC-sensitive receptor in a rat’s brain. This discovery was quickly followed up with further evidence by Dr. Raphael Mechoulam, the famous chemist who discovered THC. With less than 30 years of research, the endocannabinoid system is one of the least studied systems in the body. Currently, restrictions on cannabis research limit what scientists can examine in terms of furthering the understanding of how cannabis and hemp interact with the endocannabinoid system. Two cannabinoid receptors have been discovered by researchers: CB1 and CB2.

CB1 is found in the central and peripheral nervous system. It’s also found in the brain and is the receptor that THC interacts with, giving the user a “high.” CB2 receptors are predominantly found in the immune system and the gastrointestinal system where they regulate inflammatory responses in the bowels. CB2 receptors are also found in the brain, although not as densely as CB1 receptors. These receptors, a large part of the endocannabinoid system, play roles in regulating cardiovascular activity, appetite, mood, memory, and pain in the body. CBD does not fit exactly into either CB1 or CB2 receptors. CBD stimulates both receptors and causes a reaction without binding directly, creating changes in cells that contain them. CBD also binds to a protein-receptor couple, TRPV-1, responsible for regulating body temperature, pain, and inflammation. CBD is also known for counteracting the effects of THC, activating serotonin receptors, and inhibiting a gene attributed to several cancers.   CBD has grown in popularity recently as research and anecdotal evidence increasingly demonstrates the impact it can have on the body. The body’s endocannabinoid system reacts to CB1 and CB2 based upon the organ or bodily system that is sensitive to one or both. The brain is especially sensitive to CB1, the lungs to CB1, the spleen to CB2, the vascular system CB1, the pancreas to CB1 & CB2, the liver to CB1 & CB2, reproductive organs to CB1, the colon to CB2, the muscles to CB1, the immune system to CB2, and the bones to CB2. The endocannabinoid system (ECS) is also involved in regulating a variety of physiological and cognitive processes including fertility, pregnancy (during pre- and postnatal development) appetite, pain-sensation, mood, and memory, and in mediating the pharmacological effects of cannabis. The ECS is also involved in mediating some of the physiological and cognitive effects of voluntary physical exercise in humans and other animals, such as contributing to exercise-induced euphoria as well as modulating locomotor activity and motivational salience for rewards. In humans, the plasma concentration of certain endocannabinoids (i.e., anandamide) have been found to rise during physical activity; since endocannabinoids can effectively penetrate the blood–brain barrier, it has been suggested that anandamide, along with other euphoriant neurochemicals, contributes to the development of exercise-induced euphoria in humans, a state colloquially referred to as a runner’s high. Cannabinoids Cannabinoids are broadly known for their anti-seizure, anti-inflammatory, anti-nausea, anti-fungal, and anti-cancer effects — and science has just scratched the surface. How much these effects are expressed is a result of the entourage effect is not fully known. The entourage effect states that the cannabinoids work better in tandem than they do alone. THC and CBD produce stronger healing properties together that are shown differently based on their concentrations and the presence of other cannabinoids. In addition, terpenes, the oils that give cannabis its fragrance, contribute to the therapeutic effects of the plant on the body when paired with cannabinoids. The powerful combination of these naturally occurring chemicals produces the medical effects that have given cannabis its reputation as a wondrous medical agent.

  In California, there are twelve qualifying conditions for a medical cannabis card, including one described as, “any other chronic or persistent medical symptom that substantially limits the ability of the person to conduct one or more major life activities (as defined by the Americans with Disabilities Act of 1990) or, if not alleviated, may cause serious harm to the patient’s safety or physical or mental health.” There are over 100 known cannabinoids and we’ve only briefly described a few. There is a lot more research to be done to understand the intricacies of each cannabinoid and how they interact with each other. Cannabinoids can bind to receptor sites in either the brain (CB-1) or the body (CB-2). Cannabinoids will produce different effects on the body depending on which type of receptor site they bind to. Cannabis strains are filled with multiple cannabinoids that when consumed, bind to these sites, creating a symphony of effects on the body and thus corresponding to the wide variety of healing properties. This is why one plant can treat many different conditions. Cannabinoids begin as cannabinoid acids that are activated when heated. This heat-based activation, also known as decarboxylation, removes the acid from the molecule, turning it into a bioavailable compound that the body can register. The decarboxylated molecule is often more powerful and produces a different effect on the body than the acidic version. This is why you see both “THCA” and “THC” when looking at the contents of a cannabis strain.  

🌿 Introduction: A Living System of Discovery The endocannabinoid system (ECS) remains one of the most fascinating regulatory networks in human biology. From mood and sleep to immune balance and pain modulation, the ECS is a master regulator. Cannabinoids like CBD interact with this system in ways that continue to inspire both scientific inquiry and public imagination. With the PAiNT Research Optics Palette – Green, we bring a sharper lens to this evolving field—highlighting not only the breakthroughs but also the blind spots that demand further exploration.

🔬 Current Research Strides

  • Clinical Expansion: CBD has moved from anecdotal wellness use into formal clinical trials for epilepsy, anxiety, inflammation, and neurodegenerative conditions.
  • Mechanistic Insights: Researchers are mapping receptor subtypes (CB1, CB2, and beyond), uncovering how cannabinoids influence neurotransmitter release, immune signaling, and vascular health.
  • Formulation Innovation: Advances in delivery systems—nanoemulsions, transdermal patches, and targeted oral formulations—are improving bioavailability and consistency.
  • Agricultural Progress: Hemp cultivation under the 2018 Farm Bill has expanded genetic diversity, enabling strains optimized for high-CBD, low-THC production.

⚖️ Current Limitations

  • Regulatory Barriers: Federal scheduling and fragmented state laws continue to slow large-scale, multi-site clinical trials.
  • Data Gaps: Long-term safety data, especially for chronic use and polypharmacy interactions, remain incomplete.
  • Standardization Issues: Variability in plant genetics, extraction methods, and labeling practices undermines reproducibility and consumer trust.
  • Equity in Access: Research and product development often overlook marginalized communities most affected by health disparities and cannabis criminalization.

🎨 The PAiNT Optics Palette – Green

This editorial lens emphasizes sustainability, wellness, and regenerative potential. “Green” is not only the color of the plant but also a metaphor for growth, balance, and ecological responsibility. Through this palette, PAiNT Research frames CBD and ECS science as part of a broader movement toward integrative health and environmental stewardship.

🚀 Preparing for PAiNT Your Wagon

This blog is the first in a living research series. The next installment, PAiNT Your Wagon, will expand the conversation—exploring how predictive AI, narrative storytelling, and community engagement can accelerate cannabinoid research and policy reform. Together, these pieces will form a living research blog, where each chapter builds on the last, offering readers not just information but a roadmap for advocacy, innovation, and wellness.

✅ Closing Note The ECS is not just a scientific curiosity—it is a bridge between biology, wellness, and culture. By applying the PAiNT Research Optics Palette – Green, we illuminate both the promise and the challenges of CBD research, preparing the ground for deeper inquiry and collective action.  

AllRightsReserved-InspirationalTechnologies2024

I hope this information was helpful and informative. If you have any more questions, please feel free to ask me. 😊 Inspirational Technologies – IT is Time

We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

We are often faced with our own personal conflicts which directly influence our interactions with our peers and family. 

When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.
 

At Inspirational Technologies

Our mission is to shape public perception and policy through credible, engaging narratives that empower communities. With the PaiNT Network, we are extending that mission into the realm of predictive intelligence. By blending editorial rigor with AI foresight, we are creating a platform that doesn’t just inform—it inspires action.

As Steven Smith notes:

Looking Ahead The launch of PaiNT Research is only the beginning. In the coming months, Inspirational Technologies will:

• Roll out “Engage → Palette” cycles on our blog, showing how dialogue evolves into curated insights. • Publish “PaiNT Your Wagon” action briefs to guide policymakers and advocates. • Release “PaiNT You a Picture” visuals to make complex science accessible. • Amplify insights through “PaiNT the Town”, ensuring that predictive intelligence reaches the audiences who need it most.

P a i N T   Pallette 2025
P a i N T Your Wagon 2025
P a i N T You a Picture 2025
P a i N T the Town 2025

A Call to Collaboration We believe that predictive intelligence is not a solitary pursuit—it is a collective canvas. Every voice adds a brushstroke. Every perspective adds depth. Together, we can paint a future where research is not just conducted but understood; not just published but lived. Join us as we launch PaiNT Research. Explore the categories. Share your insights. Because the future is not something we wait for—it’s something we paint together.

Brought to you by the PaiNT Network (2025) an inspiration from Inspirational Technologies

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We, at Inspirational Technologies are at the forefront of Inspirational and Front runners on the frontier of current technology. ___________________________________________________________________________________________________All Rights Reserved – Inspirational Technologies 2025 We hope this information has been helpful and informative. Don’t hesitate to reach out with any further questions. 😊

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1st Hemp USA News is a resource of Inspirational Technologies (2021)
Created 3/1/2014
Logo by Steven M Smith Created 3/1/2014
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A Decade of Hemp Innovation: Inspirational Technologies’ Journey and Next Chapter

A Decade of Hemp Innovation: Inspirational Technologies’ Journey and Next Chapter

This is my past, present, and future vision by Steven M. Smith, Founder & CEO of Inspirational Technologies – September 2025 – Over a decade ago, Inspirational Technologies set out to combine natural wellness with advanced science, and now we’re taking a bold leap forward. Founded in 2013 by Steven Smith, our journey began as a small Florida startup with a mission to connect traditional botanical remedies with modern technology. From those modest beginnings, we’ve evolved into a leader in hemp-based innovation, driven by resilience, discovery, and a strong sense of purpose. Today, we’re thrilled to unveil a new chapter for Inspirational Technologies—building on our foundation and embracing the future of hemp and cannabinoids to bring relief to even more people.

2013–2015: Laying the Groundwork

Created 3/1/2014
Logo by Steven M Smith Created 3/1/2014

In the early years (2013–2015), we laid critical groundwork. Steven Smith’s background in plant sciences and passion for holistic health drove the initial focus on researching plant-based compounds, particularly those in hemp and other medicinal herbs. We were essentially a research lab with a big dream: to validate traditional botanical remedies using rigorous modern science. During this time, we established an education hub on our website (InspirationalTech.org) to share research updates and demystify hemp for the public. This proved vital in combating public misconceptions, as many people at the time still conflated hemp with psychoactive cannabis. Indeed, throughout the 20th century, stigma and prohibition had severely complicated cannabis research, and in the early 2010s hemp was legally categorized alongside narcotics despite its lack of THC. Navigating this environment was challenging – regulations were murky, funding was limited, and we often had to explain that hemp isn’t about “getting high,” but about healing. [Frontiers…: from …] [What Does…usinesses?]

Industial Hemp Field

Challenges: Regulatory uncertainty was the toughest hurdle in our infancy. Government rules around cannabis research were ambiguous or restrictive, making it difficult to source materials and secure funding. Public perception was another obstacle; early on, some investors and consumers were wary, not yet educated on the difference between non-intoxicating hemp compounds and marijuana. We tackled these challenges through education and transparency. By openly sharing scientific findings and safety data on our website and in community seminars, we started changing minds.
In 2014, our persistence paid off: we secured our first private investment, providing much-needed R&D capital, and validated our vision to those who believed in the potential of cannabinoids. That same year we launched our website as a content hub, positioning Inspirational Technologies as a trustworthy voice explaining the science of CBD and hemp. This focus on education built credibility and began eroding the stigma.
Successes: Despite the headwinds, by 2015 we had established a solid foundation. We had a small lab, a growing network of academic collaborators, and early data hinting at hemp’s therapeutic promise. For example, our team initiated studies on hemp-derived compounds and their effects on conditions like inflammation and anxiety, drawing on expertise from university partners. These academic collaborations not only guided our research but also validated our early findings in peer-reviewed settings, showing that our work was on the right track. We closed 2015 with optimism – and a budding reputation as pioneers willing to push botanical science into new territory.

2016–2018: Expanding into Hemp and Cannabinoids

By the mid-2010s, cannabidiol (CBD) was gaining mainstream attention as a potential wellness game-changer. Research interest in CBD was exploding worldwide, and public awareness of hemp’s benefits was on the rise. Inspirational Technologies embraced this momentum and shifted focus squarely onto hemp-derived cannabinoids. This period marked our evolution from a general plant research startup into a dedicated hemp innovation company.
Research Milestones: Between 2016 and 2018, we embarked on ambitious studies of CBD’s potential health benefits. Our research teams (now working with medical scientists) explored how CBD could help reduce anxiety, alleviate inflammation, and even act as a neuroprotective agent for the brain. Early results were promising: for instance, preliminary experiments suggested CBD had notable anti-inflammatory effects (supporting what many others were finding), and could modulate stress responses in animal models. We weren’t alone in these discoveries – around this time scientific literature was burgeoning with cannabinoid research. Academic partners working with us published validating findings, adding credibility. The scientific community was confirming what we believed: CBD and related cannabinoids held real therapeutic promise. Notably, evidence began emerging that CBD might provide relief in anxiety without the downsides of THC. (In fact, a few years later a clinical trial would show CBD can quell anxiety symptoms effectively without impairment.) The more data we gathered, the more confident we became that our path was the right one. [CBD shown…e with THC], [CBD shown…e with THC]
Product Development: Research findings quickly fed into product ideas. By 2017, we had developed our first prototypes of CBD-infused wellness products, including a topical cream for pain relief and a tincture (oral drops) for stress and general wellness. Formulating these was an exciting step from lab bench to real-world application. We sourced high-quality hemp extracts and combined them with synergistic herbs, leveraging our roots in botanical science to create unique blends. Each prototype was tested for safety and efficacy in small trials. The feedback from early testers was encouraging – users reported less joint pain after applying the cream, and better sleep with the tincture. This R&D phase taught us about effective dosing, bioavailability (for example, how well the body absorbs CBD in different forms), and user preferences. It set the stage for the full product line we’d launch once the regulatory coast was clear.
Obstacles: If you rewind to 2017, selling a hemp-based product was not straightforward. Federal law still treated hemp extracts in a gray zone, which made distribution and marketing a tricky affair. We could develop products and even give out samples, but large-scale sales were hampered by legal ambiguity. Shipping CBD across state lines lived in a legal limbo – technically hemp was still a Schedule I substance federally, even though it has no high-inducing THC. This meant we had to proceed carefully and focus on states with clear hemp programs. We also had to be very cautious about marketing language, avoiding any medical claims that could draw ire from regulators (the FDA had started warning companies about unproven claims). Yet, we persisted, keeping our operations lean and compliant. We engaged with industry groups advocating for hemp law reform, and continuously educated lawmakers and the public on CBD’s safety. All of this groundwork positioned Inspirational Technologies to spring ahead when the law finally caught up with science. [What Does…usinesses?], [What Does…usinesses?]
A Turning Point – Legalization: Late 2018 brought the breakthrough we and the entire industry had been waiting for. The U.S. Congress passed, and the President signed, the Agriculture Improvement Act of 2018 the “Farm Bill” (see our story)

December 2018 – The Farm Bill Legalized Hemp

2019–2022: Growth through innovation and Partnerships

With legal clarity achieved, Inspirational Technologies moved full speed from R&D into the marketplace. The period from 2019 to 2022 was one of rapid growth, new partnerships, and establishing our leadership in the hemp wellness space. We transitioned from a small startup into a recognized brand with a national reach.

Commercial Launch: In early 2019, we officially launched our first line of CBD-based wellness products to the public. The line included the refined versions of our topical CBD cream and sublingual tincture, now branded under the Inspirational Technologies banner, as well as capsules and an all-natural CBD balm. We leveraged e-commerce and select health store partnerships for distribution. The timing was perfect: consumer interest in CBD had exploded, and people were eager to try these newly legal remedies. In fact, by 2020 nearly one-third of U.S. adults had used a CBD product, a huge leap in adoption from just 14% in 2019. We were ready to meet the demand with products formulated on a foundation of science and quality. Each batch was lab-tested for purity and potency, and we published the results online to continue building trust through transparency.

1st Hemp USA 2021
1st Hemp USA 2021 Inspirational Technologies

Partnership with hempSMART:
A key milestone in this phase was our strategic partnership with hempSMART in 2019.
HempSMART – a California-based company known for its science-driven CBD formulations – shared a similar ethos with us. By partnering, we aimed to combine our strengths: Inspirational Technologies’ research and product innovation, with hempSMART’s established marketing channels and customer base. Together, we celebrated on product development and education. For example, we co-hosted webinars featuring experts like Paula Vetter (hempSMART’s medical advisor) to inform consumers about CBD’s benefits. This partnership expanded our reach across the U.S. and even into international markets where hempSMART had a presence. It was a win-win: hempSMART gained new formulations and R&D support, while we gained a ready distribution network and a boost in brand visibility. Collaboration has always been in our DNA, and this was a powerful example of how working with like-minded innovators could amplify our impact.
Scaling Up: Internally, these years saw our team grow and our capabilities scale. We onboarded new talent – from formulation chemists to regulatory consultants – to handle everything from product manufacturing to compliance in a fast-evolving regulatory environment. In 2020, hempSMART opened a larger production facility in Florida, enabling us to increase output to meet surging demand.
Our efforts at maintaining high standards earned recognition: by 2021, Inspirational Technologies was being recognized as a leader in hemp-based innovation, with industry magazines featuring our story and calling out our commitment to quality. We also invested in intellectual property, filing patents related to advanced cannabinoid extraction techniques and delivery methods (like a water-soluble CBD nanoemulsion to improve absorption).
This era wasn’t without its challenges, of course. The regulatory landscape, while improved, remained complex – the FDA still hadn’t fully figured out how to categorize CBD products, and we had to stay on top of patchwork state regulations. Public perception, however, continued trending in our favor. By 2022, 60% of Americans had tried CBD and believed in its benefits, reflecting a massive shift in acceptance. What was once fringe had become mainstream, found in everything from gummies and lattes to pain salves. We made sure Inspirational Technologies stood out in this crowded market by doubling down on science and trust – emphasizing evidence-backed uses, avoiding hype, and advocating for sensible regulations to protect consumers. Our reputation for integrity became one of our strongest selling points. [CBD Statis…bes Health]
Highlights 2019–2022: We achieved several key milestones in this growth phase: new product launches (including a popular CBD + herbal adaptogen capsule in 2021), revenue growth that outpaced our projections, and an expanding loyal customer community. We also saw the broader hemp industry flourish, validating our faith in this plant. (U.S. CBD product sales skyrocketed from about $108 million in 2014 to nearly $1.9 billion by 2022, illustrating the boom we were part of.) Inspirational Technologies had firmly established itself — not just as a company selling wellness products, but as an innovator helping to shape an entire industry. [CBD Statis…bes Health]

2023 and Beyond: Embracing a New Frontier

The stage is set for an exciting new chapter. As the metrics above show, the environment in 2023–2025 is remarkably different from a decade ago. Consumer acceptance of hemp remedies is at an all-time high, and the market has grown exponentially. With widespread legality and a mountain of supporting research, cannabinoids are poised to transform mainstream healthcare and wellness. In this context, Inspirational Technologies is embracing a new frontier. Our new direction will leverage everything we’ve learned over the past 12 years and push further to realize the full potential of hemp-based science. Here’s what to expect as we move forward:
1. Pioneering Advanced Therapeutics: The heart of our new direction is a commitment to deeper scientific exploration of cannabinoids and their medical potential. CBD opened the door, and now we’re walking through it with a toolkit of cutting-edge science. We are expanding our R&D to study lesser-known cannabinoids like CBG (cannabigerol) and CBN (cannabinol), which are also derived from hemp but have unique properties. For instance, recent research from Yale University highlighted CBG’s strong potential for pain relief without opioid risks, and ongoing studies suggest CBN may aid sleep. We believe these compounds, especially in synergy (the “entourage effect”), could address health issues that CBD alone hasn’t fully solved. To that end, Inspirational Technologies is initiating clinical collaborations to formally test cannabinoid-based therapies for specific conditions. We’re in discussions with medical centers to launch trials on a CBD-CBG blend for chronic neuropathic pain and on a cannabinoid regimen for anxiety and PTSD. The goal is to move beyond wellness products into the realm of evidence-backed therapeutics – bridging the gap between supplement and medicine. It’s an ambitious step, but it’s aligned with our founding mission of merging nature with advanced science. The scientific promise is truly compelling: studies show cannabinoids might offer safer alternatives to opioids for pain, relieve anxiety without harsh side effects, and even help in neurodegenerative diseases like Alzheimer’s. In 2018, the U.S. FDA approved its first CBD-based prescription drug for severe childhood epilepsy, validating that cannabinoids can meet the highest standards of medicine. We foresee a future where cannabinoid therapies are a trusted part of mainstream healthcare, and we want to be at the forefront of that movement. Our new direction prioritizes rigorous research, so doctors and patients can have confidence in the hemp-derived treatments we develop. [Cannabinoi…ain relief], [Cannabinoi…ain relief] [Cannabinoi…ain relief] [CBD shown…e with THC], [CBD shown…e with THC] [Frontiers…: from …] [What Does…usinesses?]

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2. Emerging Applications in Disease Relief: We are also broadening the applications of our products to target more specific needs. Over the years, customers have shared incredible stories of finding relief with our creams and tinctures – from an athlete’s persistent knee pain easing to an anxious traveler finally enjoying a calm flight. These experiences inspire us to tailor solutions for some of the most prevalent and pressing health challenges. Chronic pain, for example, affects millions and often leads to dependence on painkillers. With cannabinoids showing effectiveness in reducing inflammation and pain signaling, we are formulating targeted pain-relief applications, such as an advanced arthritis cream and oral supplements for inflammatory conditions. Mental health is another focus: anxiety and sleep issues are on the rise, and many are seeking natural relief. We’re exploring blends of CBD with terpenes and botanicals known for calming effects, to support those struggling with stress or insomnia. Early next year, we plan to release a CBD+CBN nightly tincture aimed at improving sleep quality naturally. On the more advanced end, we’re keeping an eye on research that suggests cannabinoids could play a role in serious conditions like cancer. A recent comprehensive study even found evidence that cannabis compounds might help fight certain cancer cells and improve patients’ quality of life. While we remain grounded in science (and such uses will require extensive validation), it underscores a key point: the therapeutic horizon of hemp is still expanding. Our new product roadmap is designed to adapt as new discoveries emerge. If a study finds that a CBD-THC combination (with minimal THC) works best for a given condition, we have the agility and knowledge to formulate accordingly – always within legal bounds. In short, we’re widening our scope from general wellness to targeted solutions for disease relief, driven by what science and our users tell us. [Cannabinoi…ain relief] [New Study…naging …], [New Study…naging …]
3. Market Expansion and Leadership: As we venture into these new arenas, Inspirational Technologies is committed to growing sustainably and responsibly. The hemp and CBD industry is maturing – consolidation is happening, regulations are catching up, and consumers are becoming more discerning. We see this as a positive evolution and aim to be a leader in the next phase of the market’s development. Part of our new direction involves stepping up our role in industry advocacy. We are actively engaging with policymakers and regulatory bodies to help shape commonsense regulations for hemp products. Our stance is that quality and safety standards are needed to weed out bad actors selling mislabeled or impure products. We’re advocating for measures like third-party lab testing requirements, proper labeling, and research-based dosage guidelines. We’re also preparing for the potential regulatory changes ahead. The FDA in the U.S. has hinted at developing a new framework for CBD in dietary supplements or foods, and bipartisan bills in Congress aim to clarify CBD’s legal status further. We welcome clearer regulations, and our team is proactively ensuring that whenever new rules come, we will not just comply but excel under them.
On the market front, we are exploring geographic expansion. Hemp’s acceptance is global now – countries across Europe, Latin America, and Asia-Pacific are embracing hemp CBD as laws evolve. Through the next couple of years, we plan to enter select international markets. We’re already laying groundwork in Canada and the EU, navigating their approval processes to offer our products abroad. Additionally, we’ll continue forging strategic partnerships. Just as our alliance with hempSMART accelerated U.S. growth, we’re eyeing partnerships in new regions (for example, a potential joint venture in Europe with a local wellness company) to bring our expertise to new audiences. At home, as the competitive landscape grows, we differentiate by staying true to science and innovation.
Product innovation remains key: our R&D pipeline includes not only new formulations but also new delivery technologies (imagine a transdermal patch for steady cannabinoid release, or a smart dispenser that gives personalized doses based on an app). Advanced technology – from bioinformatics to AI-driven data analysis – will increasingly inform how we design and validate our products, fulfilling the “advanced science” part of our mission with even greater precision.
Finally, as we look beyond 2025, Inspirational Technologies’ core values stay constant. The resilience, curiosity, and purpose that got us through the past decade will guide us in the next. We envision a future where a person with chronic pain might use a cannabinoid therapy we helped develop instead of habit-forming opioids; where someone with anxiety can find calm through a natural remedy backed by clinical evidence; and where hemp-based innovations contribute to a healthier, more sustainable world. The journey from a startup in 2013 to here has taught us that nature’s solutions and human ingenuity are an unstoppable combination. Our new direction doubles down on that truth. [Cannabinoi…ain relief]

Milestones and Future Goals at a Glance

To recap our journey and where we’re headed, here’s a summary of Inspirational Technologies’ major milestones over the past decade and our key goals for the future:
Year/Period Major Milestones Future Goals
2013 Founding: Steven Smith establishes Inspirational Technologies in Florida with a mission to merge natural wellness and advanced science. Begins research into hemp and medicinal herbs. Global Health Impact: Leverage hemp compounds to improve lives worldwide, bridging nutraceuticals and pharmaceuticals.
2014 First Investment & Website Launch: Secures initial private funding. Launches InspirationalTech.org as an educational hub to share research and combat misconceptions about hemp. Educational Leadership: Continue to educate consumers and health professionals about cannabinoids, setting industry standards for transparency.
2015 Research Foundations: Early lab studies on hemp compounds suggest potential benefits (anxiety reduction, anti-inflammatory effects). Establishes academic collaborations to validate findings. Research & Development: Invest in clinical trials and R&D for new cannabinoid therapies (e.g., pain, anxiety, neuroprotection), turning promising research into approved treatments.
2016–2017 Focus on CBD & Product Prototypes: Pivots to focus on hemp-derived CBD as interest grows. Develops first CBD product prototypes (topical cream and tincture) blending botanical science with tech. Product Innovation: Develop next-gen products (e.g., multi-cannabinoid formulas, improved delivery systems like patches or nano-emulsions) for more effective relief.
2018 Regulatory Breakthrough: U.S. Farm Bill 2018 legalizes hemp federally [What Does…usinesses?], [What Does…usinesses?], removing major legal barriers. Inspirational Tech poised to enter the national market with tested products. Quality & Compliance: Lead in product quality, exceeding regulatory requirements. Work with regulators (FDA, etc.) to establish clear guidelines that ensure consumer safety and trust.
2019 Product Launch & hempSMART Partnership: Launches first retail products nationwide. Partners with hempSMART to expand reach and co-develop offerings, boosting brand visibility and distribution. Strategic Partnerships: Build new alliances (with wellness companies, research institutes, healthcare providers) to expand globally and integrate hemp solutions into mainstream wellness and medicine.
2020–2021 Rapid Growth: Surges in customer adoption amid rising CBD popularity. Expands team and facilities; recognised in industry for science-driven approach. U.S. CBD use jumps (33% of Americans by 2020) despite lingering stigma. Market Expansion: Enter new markets in Europe, Canada, and Asia as global hemp legalization progresses. Continue to adapt to market trends and consumer needs with agility.
2022 Industry Leadership: Establishes itself as a leading hemp innovation company. By 2022, U.S. CBD sales reach $1.9B [CBD Statis…bes Health] and 60% of adults have tried CBD [CBD Statis…bes Health] – a testament to growing acceptance that Inspirational Tech helped foster. Industry Leadership & Advocacy: Influence the hemp industry’s evolution by advocating for sustainable practices, environmental responsibility in cultivation, and social responsibility in marketing (ensuring products are used appropriately for wellness).
2023 New Initiatives: Kicks off new R&D projects on cannabinoids like CBG/CBN for pain and sleep. Prepares for clinical collaborations to formally study cannabinoid therapies. Company culture shifts toward biotech startup mindset (hiring medical liaisons, data scientists). Therapeutic Breakthroughs: Aim to achieve at least one FDA-approved cannabinoid therapy in the next 5–7 years, bringing a natural yet scientifically-vetted medicine to patients (e.g., a prescription CBD/CBG pain reliever).
2024 Preparation for New Direction: Aligns strategy with market trends and scientific advances. Strengthens compliance team for anticipated regulations. Engages with lawmakers on CBD policy. Concepts for personalized cannabinoid wellness programs (leveraging AI) in development. Personalized Wellness: Utilize technology (AI and data analytics) to tailor cannabinoid-based solutions to individual needs, ushering in an era of personalized, plant-based medicine.
2025 & Beyond Announcing New Direction: Unveils a forward-looking strategy focusing on advanced research, broader health applications, and global expansion. Poised to integrate hemp-based innovation into healthcare on a larger scale, staying true to the vision of holistic wellness powered by science. Vision 2030: By 2030, become a global pioneer in cannabinoid science, with a portfolio spanning consumer health products, licensed medical treatments, and technological platforms – all while maintaining the trust and holistic principles that have defined Inspirational Technologies since 2013.
Conclusion: by Steven M. Smith
“As we step into this new chapter, Inspirational Technologies remains guided by the same principle that sparked our founding: the belief that nature and science together can improve lives. Our journey from 2013 to 2025 has been one of learning, innovating, and breaking barriers. We transformed challenges into opportunities – whether overcoming legal hurdles or shifting public perception – and in doing so, we’ve helped pave the way for hemp-based wellness worldwide. The future of hemp and cannabinoids is bright. From emerging scientific breakthroughs to evolving market dynamics, all signs point to an era where these natural compounds take a more central role in health and wellbeing.
With our rich history and renewed focus, we’re ready to lead in that era. The coming years will see Inspirational Technologies diving deeper into research, launching exciting new solutions, and reaching people in ways we once only imagined. We extend our heartfelt thanks to our supporters, partners, and customers who have believed in our mission. Together, we are forging a new path for natural wellness – one that honors ancient wisdom, embraces modern innovation, and inspires a healthier future for all.”
Stay tuned for more updates as we embark on this journey ahead. The best is yet to come.
[Cannabinoi…ain relief], [New Study…naging …]

Sources

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In New Hampshire, under HB 1278, doctors can now recommend cannabis for potential benefits.

new hampshire medical marijuana

New Hampshire Governor Chris Sununu (R) recently signed into law a significant expansion of the state’s medical marijuana program, a move that broadens access to cannabis for patients with a wide range of conditions.

This new legislation, HB 1278, marks a major shift from previous restrictions, which limited eligibility to specific, enumerated conditions, reported Marijuana Moment.

Broadening Access: What New Law Means For Medical Marijuana Patients

The new law significantly alters the landscape of medical marijuana use in New Hampshire. Under HB 1278, doctors can now recommend cannabis for “any debilitating or terminal medical condition or symptom for which the potential benefits of using therapeutic cannabis would, in the provider’s clinical opinion, likely outweigh the potential health risks for the patient.”

This provision is set to replace the previous, more restrictive list of qualifying conditions, allowing for greater flexibility in patient care.

This broader eligibility could potentially address a range of conditions previously overlooked, such as severe menstrual cramps, symptoms of long COVID and anxiety related to dental procedures or post-surgical pain control.

Recent Legislative Changes In NH

The enactment of HB 1278 follows two other recent legislative changes signed by Sununu that also expand the medical marijuana program.

One of these bills adds generalized anxiety disorder as a qualifying condition, while another broadens the pool of healthcare providers who can certify patients for the program.

However, not all of Sununu’s recent decisions regarding medical marijuana have been supportive. Last month, he vetoed a bill that would have allowed medical marijuana businesses to open additional cultivation locations, including greenhouses. Sununu’s veto statement criticized the bill for lacking sufficient detail on safety, security, and location requirements.

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We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

We are often faced with our own personal conflicts which directly influence our interactions with our peers and family. 

When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.

Steven M Smith InspirationalTech.org CEO since 2013.

Thank you for consideration.
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Continue reading In New Hampshire, under HB 1278, doctors can now recommend cannabis for potential benefits.
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CBD May Be the “Missing Link”! – Understanding Cannabis and the “Endogenous Cannabinoid” or Endocannabinoid System.

 

 

 

 

Mature Hemp Field Crop Hemp Is Now A Viable Agriculture Phenomenon

 

Cannabis and the Endocannabinoid System

The Wonders of CBDs

CBD Molecule

Cannabinoids are the chemical compounds made by the cannabis plant that unlock its many healing secrets.

There are over 100 known cannabinoids and these chemicals imitate the endocannabinoids naturally produced in the human body.

The shiny little crystals you see on cannabis buds are called trichomes where cannabinoids are stored.

Human bodies (and many animals) have endocannabinoid systems (ECS), meaning that cannabinoids are naturally made so they can bind to endocannabinoid receptors creating changes in our physiology.

To understand the master gland and immune system of the human body it is crucial to have a basic understanding of the endogenous cannabinoid system, otherwise known as the endocannabinoid system (ECS).

The endocannabinoid system is essential to human health because it maintains homeostasis in the body.

Research into the endocannabinoid system has increased in recent years as scientists begin to reveal how complex and important this system is to our bodies.

The legal cannabis movement started in San Francisco in the early 1990’s when it was discovered that cannabis treated many symptoms that AIDS patients suffered from, including pain.

It was medical marijuana laws that changed the legal status of cannabis nationwide, opening the doors for research and an adult-use market and creating a path towards full legalization.

Cannabis patients across the country have used the plant to treat a growing number of medical conditions.

In Colorado alone, there are nine different qualifying conditions for a medical card: cancer, glaucoma, HIV or AIDS, cachexia (wasting syndrome), persistent muscle spasms, seizures, severe nausea, severe pain, and Post Traumatic Stress Disorder (PTSD).

 

What Do CBD’s Do?

The endocannabinoid system (ECS) is responsible for maintaining homeostasis in the body. Homeostasis is defined as: “any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival.”

If homeostasis is successful, life continues; if unsuccessful, disaster and ill health ensues.

The endocannabinoid system is made up of three parts:

cannabinoid receptors, endocannabinoids, and metabolic enzymes.

 

• Endocannabinoid receptors are found throughout the body on the surface of cells in the brain, organs, tissues, and glands. These receptors are embedded in cell membranes and produce varying reactions when stimulated by cannabinoids.

• Cannabinoids come from two distinct places — the body, which produces naturally occurring endocannabinoids, and foods like the cannabis plant, which produces phytocannabinoids.

• Metabolic enzymes act like a natural referee in that they destroy endocannabinoids once they are used up by the body. The two main metabolic enzymes are fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

This self-regulating system ensures the interaction of CBDs with the ECS only happens when needed and therefore keeps the workings of the endocannabinoid system relatively quiet to the conscious brain.

Because homeostasis is so important to health, all vertebrates and invertebrates are known to have an endocannabinoid system.

 

Cannabinoids can also be produced synthetically. Marinol (dronabinol) and Cesamet (nabilone) are synthetic versions of THC that have FDA approval to be marketed and sold as a prescription drug.

Synthetic cannabinoids do unlock the endocannabinoid system to produce effects, but they often fail to incorporate the entourage effect which states that the sum of the different cannabinoids works better as a whole unit than any cannabinoid individually.

With an understanding of the endocannabinoid system and its role in ensuring homeostasis in the body, it may be easier to see how this could be true.

The Endocannabinoid System

Despite its critical importance, the endocannabinoid system (ECS) was only discovered in the early 1990s when Lisa Matsuda, a researcher at the National Institute of Mental Health, and her colleagues discovered a DNA sequence that defines a THC-sensitive receptor in a rat’s brain.

This discovery was quickly followed up with further evidence by Dr. Raphael Mechoulam, the famous chemist who discovered THC.

With less than 30 years of research, the endocannabinoid system is one of the least studied systems in the body.

Currently, restrictions on cannabis research limit what scientists can examine in terms of furthering the understanding of how cannabis and hemp interact with the endocannabinoid system.

Two cannabinoid receptors have been discovered by researchers: CB1 and CB2.

CB1 is found in the central and peripheral nervous system. It’s also found in the brain and is the receptor that THC interacts with, giving the user a “high.”

CB2 receptors are predominantly found in the immune system and the gastrointestinal system where they regulate inflammatory responses in the bowels.

CB2 receptors are also found in the brain, although not as densely as CB1 receptors.

These receptors, a large part of the endocannabinoid system, play roles in regulating cardiovascular activity, appetite, mood, memory, and pain in the body.

CBD does not fit exactly into either CB1 or CB2 receptors.

CBD stimulates both receptors and causes a reaction without binding directly, creating changes in cells that contain them.

CBD also binds to a protein-receptor couple, TRPV-1, responsible for regulating body temperature, pain, and inflammation.

CBD is also known for counteracting the effects of THC, activating serotonin receptors, and inhibiting a gene attributed to several cancers.

 

CBD has grown in popularity recently as research and anecdotal evidence increasingly demonstrates the impact it can have on the body.

The body’s endocannabinoid system reacts to CB1 and CB2 based upon the organ or bodily system that is sensitive to one or both.

The brain is especially sensitive to CB1, the lungs to CB1, the spleen to CB2, the vascular system CB1, the pancreas to CB1 & CB2, the liver to CB1 & CB2, reproductive organs to CB1, the colon to CB2, the muscles to CB1, the immune system to CB2, and the bones to CB2.

The endocannabinoid system (ECS) is also involved in regulating a variety of physiological and cognitive processes including fertility, pregnancy (during pre- and postnatal development) appetite, pain-sensation, mood, and memory, and in mediating the pharmacological effects of cannabis.

The ECS is also involved in mediating some of the physiological and cognitive effects of voluntary physical exercise in humans and other animals, such as contributing to exercise-induced euphoria as well as modulating locomotor activity and motivational salience for rewards.

In humans, the plasma concentration of certain endocannabinoids (i.e., anandamide) have been found to rise during physical activity;

since endocannabinoids can effectively penetrate the blood–brain barrier, it has been suggested that anandamide,

along with other euphoriant neurochemicals,

contributes to the development of exercise-induced euphoria in humans, a state colloquially referred to as a runner’s high.

Cannabinoids

Cannabinoids are broadly known for their anti-seizure, anti-inflammatory, anti-nausea, anti-fungal, and anti-cancer effects — and science has just scratched the surface.

How much these effects are expressed is a result of the entourage effect is not fully known.

The entourage effect states that the cannabinoids work better in tandem than they do alone.

THC and CBD produce stronger healing properties together that are shown differently based on their concentrations and the presence of other cannabinoids. In addition, terpenes, the oils that give cannabis its fragrance, contribute to the therapeutic effects of the plant on the body when paired with cannabinoids.

The powerful combination of these naturally occurring chemicals produces the medical effects that have given cannabis its reputation as a wondrous medical agent.

 

In California, there are twelve qualifying conditions for a medical cannabis card, including one described as, “any other chronic or persistent medical symptom that substantially limits the ability of the person to conduct one or more major life activities (as defined by the Americans with Disabilities Act of 1990) or, if not alleviated, may cause serious harm to the patient’s safety or physical or mental health.”

There are over 100 known cannabinoids and we’ve only briefly described a few.

There is a lot more research to be done to understand the intricacies of each cannabinoid and how they interact with each other.

Cannabinoids can bind to receptor sites in either the brain (CB-1) or the body (CB-2).

Cannabinoids will produce different effects on the body depending on which type of receptor site they bind to.

Cannabis strains are filled with multiple cannabinoids that when consumed, bind to these sites, creating a symphony of effects on the body and thus corresponding to the wide variety of healing properties.

This is why one plant can treat many different conditions.

Cannabinoids begin as cannabinoid acids that are activated when heated.

This heat-based activation, also known as decarboxylation, removes the acid from the molecule, turning it into a bioavailable compound that the body can register.

The decarboxylated molecule is often more powerful and produces a different effect on the body than the acidic version. This is why you see both “THCA” and “THC” when looking at the contents of a cannabis strain.

Here is a list of a few of the well-known types of cannabinoids and their effects:

THCA

Delta 9 THC is arguably the most widely known cannabinoid. When people refer to “getting high” they are referring to the experience of the psychoactive effects of THC.

THC begins as THCA, tetrahydrocannabinolic acid, which is one of the most abundant cannabinoids found in cannabis.

When THCA is heated and turned into THC, it binds to CB1 receptors in the brain producing psychoactive effects.

THC is the only known cannabinoid to produce a psychoactive response, a high, and strong therapeutic benefits.

CBDA
Cannabidolic acid is very abundant in the cannabis plant and turns into CBD when heated.

Preclinical studies demonstrate that CBDA is a strong antiemetic used to treat vomiting and nausea and is often given to mitigate the side effects of opioid use or chemotherapy.

CBD
Cannabidiol has exploded in popularity in recent years.

CBD has been the subject of much scientific interest after it hit the mainstream in 2014, following a CNN documentary in which a non-psychoactive, CBD rich cannabis strain, helped a five-year-old girl with severe epilepsy drastically reduce her daily seizure count.

The FDA has approved the first ever CBD-based drug for seizures. CBD is making waves in its ability to treat pain, nausea, anxiety, sleep disorders, and more.

 

CBGA
Cannabigerolic acid is a precursor to one of the three main cannabinoid lines: THCA, CBDA, and CBCA.

CBGA is the chemical parent to THC and CBD. Enzymes direct it down one of these lines before heat can change it into different forms. CBGA can help reduce inflammation and relieves pain.

CBG
Cannabigerolic is considered a minor cannabinoid because it is present in very low levels. It’s also powerful in treating glaucoma because it is a strong vasodilator meaning that it widens blood vessels. This helps increase blood flow and provide oxygen to the tissues that need it.

CBG is showing promise as an effective antibacterial, anticancer, and neuroprotectant.

CBCA
Cannabichromenic acid is one of the three main cannabinoid lines. It is used to treat fungal infections like athlete’s foot and ringworm.

CBC
Cannabichromenic, binds poorly to CB1 receptors in the brain, but it binds well with other pain-related receptors, helping to increase the body’s levels of natural endocannabinoids. CBC may be impactful against cancer because of this. CBC has also been shown to be an inhibitor of acne.

In conjunction with the THC and CBD, CBD also appears to have antidepressant effects.

CBN
Cannabinol is the result of THCA over time breaking down and turning into CBN. CBN has been shown to delay symptom onset of Lou Gehrig’s disease in mice indicating that it may help with motor neural diseases. CBN is also known for its anti-asthmatic, anti-inflammatory, and sedative properties.

THCV
Tetrahydrocannabivarin is similar to THC, but with a few less carbon atoms. THCV has been shown to be an anticonvulsant, has neuroprotective properties and may be an appetite suppressant.

CBDV
Cannabidivarin is a less potent version of CBD. The CBDV molecule is similar to CBD but has been changed in some ways. CBDV is an anti-nausea and anti-epileptic. CBDV is a powerful anticonvulsant. A 2012 study shows that CBDV stopped seizures in mice and rats.

In general, CBDs, cannabidiols, can be taken into the body in different ways – from smoking cannabis to eating CBD-rich food substances, as a drink, as an aerosol spray into the cheek, or transdermally.

CBD oil, containing only CBD derived from hemp as the active ingredient, is legal in all 50 States and has no tetrahydrocannabinol (THC) in the oil. Some types of CBD oil may contain THC or one of many other CBD-like compounds that can be refined into a distillate and then made into oils, pills, foods, candies, drinks, many forms of hash, salves, creams, and many other substances used as medicine.

Other Foods that Contain CBDs

You may be surprised to know that cannabinoids aren’t limited to their presence within cannabis and hemp plants and feature in many household foodstuffs that you probably already have in your kitchen.

The cannabinoids that are produced in plants are called phytocannabinoids.

So, if you want to enhance your body’s own endocannabinoid system, look at the following list of foods and consider adding them to your diet.

Black Pepper contains the terpene beta-caryophyllene (BCP) that will bind to the same cannabinoid receptors that THC does and produces a calming, relaxing effect and is also known for its anti-inflammatory action. Current research is going on into BCP’s effects within cancer treatment and for conditions such as arthritis and osteoporosis. To achieve instant and natural calming effects, it is recommended to eat 3 or 4 cloves (high in BCPs) or use them in cooking or teas.

Dark Chocolate that contains cacao as its main ingredient is high in anandamide. Cacao or its full name Theobroma Cacao (translates as “food of the gods”) has been known to be a superfood for millennia. It contains a high concentration of a cannabinoid called anandamide, which is also naturally produced in the body. Anandamide is known as the body’s own natural antidepressant and is often referred to as the human body’s natural version of THC.

Rosemary, Cloves, Basil, Oregano, Lavender & Cinnamon all contain cannabinoids, most commonly beta-caryophyllene (BCP). The terpene’s present in these herbs help contribute to the specific aroma that each one has. These terpenes are also present in marijuana plants and contribute to their aromas.

Hops – humulus lupulus – share a common ancestor with the cannabis family of plants if you follow the history back to the Order Urticales and the Family Cannabinaceae — they share similar properties genetically.

Flax Seed has many compounds within it that are very similar to the cannabinoid cannabidiol (CBD) as well as containing CBD itself. The CBD within flax has anti-inflammatory properties and develops autoimmune response.

CBD Legal Status

In the United States, CBD’s legal status depends on the source from which it is derived. When derived from marijuana it is a Schedule I controlled substance under the federal Controlled Substances Act (CSA). When CBD is derived from hemp or some other lawful source it is not a controlled substance. Hemp is excluded from the definition of marijuana under the Controlled Substances Act (CSA). CBD is not specifically scheduled in the CSA and is therefore lawful when derived from hemp, which is not a controlled substance and the definition of which includes cannabinoids.

In 2013, a CNN program brought increased attention to the use of CBDs in the treatment of seizure disorders. Since then, 16 states have passed laws to allow the use of CBD products with a doctor’s recommendation (instead of a prescription) for treatment of certain medical conditions. This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content. Of these 30 states, eight have legalized the use and sale of cannabis products without requirement of a doctor’s recommendation.

The 2014 Farm Bill legalized the sale of “non-viable hemp material” grown within states participating in the Hemp Pilot Program. This legislation defined hemp as cannabis containing less than 0.3% of THC delta-9, grown within the regulatory framework of the Hemp Pilot Program.

The 2018 Farm Bill allowed for interstate commerce of hemp derived products (CBD oil), though these products still fall under the purview of the FDA.

Legal CBD Oil and Your Health

The body’s endocannabinoid system is vital for the overall balance of the immune system, sleep, the digestive tract, cognitive functioning, and the health of the nervous system.

Hemp extract, which is legal in all 50 States (CBD oil) has been shown to provide incredible support to the human endocannabinoid system.

Numerous studies have proven CBD oil to relieve chronic pain, reduce anxiety and depression, as well as benefit heart health and many other ailments.

Also, hemp extracted CBD oil has been used to treat patients diagnosed with Parkinson’s, Alzheimer’s, diabetes, and even cancer with positive effects.

According to an article published in Forbes in 2018, the CBD market was looking to grow by 700% by the year 2020 because of positive health benefits experienced by a growing number of individuals.

According to a new estimate from cannabis industry analysts The Brightfield Group, the hemp CBD market alone could hit $22 billion by 2022.

Skeptics who assume CBD is just 21st-century snake oil, may be surprised to learn that the substance is being studied as a potential treatment for maladies as diverse as schizophrenia, insomnia and cancer.

“CBD is the most promising drug that has come out for neuropsychiatric diseases in the last 50 years,” said Dr. Esther Blessing, an assistant professor at New York University School of Medicine, who is coordinating a study of CBD as a treatment for post-traumatic stress disorder and alcohol use disorder.

“The reason it is so promising is that it has a unique combination of safety and effectiveness across of very broad range of conditions.”

The National Institutes of Health database lists about 150 studies involving CBD as a treatment for conditions as varied as infantile spasms and Parkinson’s disease. And the research has led to medical treatments.

The Food and Drug Administration approved a cannabidiol-based drug called Epidiolex as a treatment for severe forms of epilepsy, representing the first government-sanctioned medical use for CBD.

Preliminary research also indicates that CBD may be effective as an antipsychotic in reducing the symptoms of schizophrenia, with fewer side effects compared with current antipsychotic drugs.

CBD has also shown promise to reduce cravings among people addicted to opioids, according to a study published in Neurotherapeutics in 2015.

It may fight cancer, too. The authors of a review published in the British Journal of Clinical Pharmacology in 2012 wrote: “evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.”

CBDs and Evolution

What is the evolutionary impetus for the creation of cannabinoids? Even single-cellular organisms like cyanobacteria – the descendant of the original photosynthetic bacteria – produce chemicals that act on cannabinoid receptors. But the cannabinoid receptors evolved much later, first appearing in the ancient Hydra (not the god) around 500 million years ago.

It is still unclear why plants produce cannabinoids without corresponding receptors to bind with. Some insects do the same. There may be an undiscovered mechanism by which plants regulate themselves with phytocannabinoids that has yet to be found – like so many other aspects of the ECS.

In humans, the ECS has developed into a homeostatic system – a fundamental adaptive mechanism that enables our bodies to maintain health through the stresses of life.

CBDs are all the rage these days and has become a wellness craze.

Unfortunately, it is fashionable to fixate on a single cannabis component. But we should not lose sight of the fact that well-known herbal medicine provides countless remedies relevant to modern disease.

Ultimately, purified pharmaceuticals are not inherently superior to multicomponent, whole plant formulations.

These whole plant remedies have been used for millennia and we would be well-advised to not forget the wisdom of the ancients.

At this point in time, single-molecule CBD and single-molecule THC are both FDA-approved medications.

The medical development of cannabinoids should build upon traditional knowledge and herbal folk-wisdom, which often involved a mixture of various CBD herbs and foods, including CBD-rich cannabis, which has been part of the human pharmacopeia for thousands of years.

At least with herbs we have a long, successful history, while novel pharmaceutical development is experimental without many longitudinal studies.

History, on the other hand, has proven that hemp and other CBD rich foods, herbs, drinks and spices have been at the heart of the human diet since our first ancestors discovered CBD-rich nourishment which is crucial for human health.

As we welcome hemp and cannabis back into the pantheon of medicinal herbs, let’s honor the “crude” plants that have sustained humankind since time immemorial.

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I hope this information was helpful and informative. If you have any more questions, please feel free to ask me. 😊

Inspirational Technologies – IT is Time

We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

We are often faced with our own personal conflicts which directly influence our interactions with our peers and family. 

When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.

Steven M Smith InspirationalTech.org CEO since 2013.

Thank you for consideration.

Inspirational Technologies
InspirationalTech.org for your Health Wellness Beauty and Inspirational Goals

For More Information on Cannabis and CBD and YOU.

AllRightsReserved2024

1st Hemp USA News is a resource of Inspirational Technologies (2024)
Continue reading CBD May Be the “Missing Link”! – Understanding Cannabis and the “Endogenous Cannabinoid” or Endocannabinoid System.
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Can CBD Improve My Health and Wellness?

 Oil, gummies and what you should know.

The global cannabidiol, or CBD, market is exploding, with analysts projecting it will hit 22.05 billion by the year 2030. That’s nearly 20% of the size of the global soft drinks market even though CBD was only legalized in the U.S. in 2018 while the soda market has existed here for nearly 200 years.

In a few short years, CBD products have sprouted up everywhere and are available for purchase in the form of oils absorbed on one’s tongue, edibles such as gummies, candies, foods, pills or beverages, topical applications of ointments, creams or lotions absorbed on one’s skin, and inhalation by vaping or smoking.

What is CBD?

CBD is a chemical compound largely derived from hemp in the cannabis (marijuana) sativa plant. The plant has over 85 chemicals that are identified as cannabinoids, but cannabidiol is the most frequently used one for medical purposes due to its lack of psychoactive effect.

There are three main types of CBD:

  • full-spectrum CBD, which contains all beneficial compounds naturally found in the cannabis plant;
  • broad-spectrum CBD, which contains only some such compounds;
  • and CBD Isolate or “pure CBD,” which doesn’t contain any delta-9-tetrahydrocannabinol, or THC, nor any other compound from the hemp plant.

Legally, no CBD products can contain more than 0.3% (by dry weight) of THC, the mind-altering substance in marijuana known for its psychoactive effects.

Because of this, “CBD is not intoxicating and will not make you high” as some people believe, explains Janice Newell Bissex, MS, RDN, FAND, holistic cannabis practitioner at Jannabis Wellness. Instead, “CBD interacts with our endocannabinoid system,” she says. One’s endocannabinoid system (ECS) is a widespread neuromodulatory system that “plays a role in regulating pain, mood, immune function and inflammation,” says Josh Redd, NMD, the founder of RedRiver Health and Wellness and author of “The Truth About Low Thyroid.”

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What does CBD do?

In this interaction with one’s endocannabinoid system, the chemical compound works to calm one’s nervous system, reduce inflammation and alleviate some chronic pain symptoms. Harvard Medical School says “there is moderate evidence that CBD can improve sleep disorders, fibromyalgia pain, muscle spasticity related to multiple sclerosis and anxiety.”

Bissex adds that some people find that CBD can also be a helpful treatment for traumatic brain injuries or seizures. Redd says the chemical compound has properties that can alleviate some epilepsy symptoms and provide autoimmune management as well.

Is CBD considered a drug?

Though CBD does affect the structure or function of the body, as the Food and Drug Administration (FDA) defines a drug, CBD is not classified as a narcotic drug. The Centers for Disease Control and Prevention (CDC) notes that CBD is not impairing, and the World Health Organization‘s Commision in Narcotic Drugs found that the chemical “has no potential for abuse and no potential to produce dependence.” Bissex adds that CBD has a good safety profile and is “generally well tolerated.”

Redd agrees that the chemical is well received by most users but says we still “lack long-term studies.” He adds that “the biggest concern with CBD is that the market is not fully regulated, and the quality and purity of CBD products can vary.” The CDC similarly notes a lack of regulation and says that because scientists are still learning about how CBD affects the body, it strongly suggests keeping CBD products “in childproof containers and out of the reach of children.”

The agency also warns adult users of potential harms and side effects associated with taking CBD products. These include liver damage, upset stomach, changes in one’s appetite, irritability and interference with other drugs one is taking that may cause more serious problems. Bissex says other side effects of using CBD products may also include “vivid dreams, fatigue and low blood pressure.”

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We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

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Continue reading Can CBD Improve My Health and Wellness?
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What Is CBD & How Does it Work?

CBD has been taking the health and wellness industries by storm. From oils and tinctures to gummies and lotions, the numerous varieties of CBD products available today are remarkable. The incremental growth of the CBD oil market alone is estimated to be $3.52 billion between 2019 and 2024. But what actually is CBD and how does it work? Read on for a beginner’s breakdown to what CBD is, why it works in the human body and who can use CBD for what.

 

What is CBD?

Cannabidiol, often abbreviated to CBD, is a naturally occurring compound found in the Cannabis sativa plants, hemp and cannabis. Manufacturers extract and process the CBD to isolate it for various uses; besides the oils, there are edibles and topicals.

How is CBD different from THC?

THC, or tetrahydro-cannabidiol, is the main psychoactive component in the cannabis plant that creates a “high” sensation. THC is primarily consumed through inhalation of smoke or through edibles, oils or capsules. Both THC and CBD interact with bodily systems, but according to research, THC interacts primarily with CB1 receptors which are linked to the high or euphoric feeling. Hemp plants contain a higher percentage of CBD while maintaining very low levels of THC.

How Does CBD Work in the Body?

CBD works directly with the human body’s endocannabinoid system, or ECS. CBD intercepts both the CB1 and CB2 receptors in the ESC, which are primarily responsible for transmitting messages to the brain. The ECS regulates a broad spectrum of biological and physiological processes including pain management, inflammation, sleep, mood, digestion and more.

What Are the Health Benefits?

The health benefits of CBD are being recognized. In June 2018, the FDA approved the first prescription medication containing CBD, Epidiolex. It is used to treat rare and difficult-to-control forms of epilepsy. Because CBD regulates receptors, researchers hope that early research showing promise for certain autoimmune diseases will show the same results in humans. Proprietary research indicates CBD could help:

-inflammation

-chronic pain

-anxiety

-depression

Though CBD is rapidly gaining in popularity, there are more clinical trials and studies needed to confirm its full impact and effectiveness. There has been some evidence of side effects accompanying CBD, but if you are a first time user consulting your doctor, or a medical professional is always a good place to start.

Is CBD Legal?

December 2018 – The Farm Bill Legalized Hemp

 

Cannabis- and hemp-related laws in the United States are evolving and changing rapidly. Hemp, when produced at levels below 0.3% delta-9 THC, is not considered a controlled substance at the federal level. Hemp-derived CBD is accessible in most of the 50 states. A Drug Enforcement Administration registration is not required to grow or research it.

Industrial hemp, given in its legal definition in the 2018 Farm Bill, is legitimate if companies are transparent in their manufacturing process and label claims. But each state has its own laws and regulations, so check with your state’s protocols before purchasing CBD.

CBD Takeaways

The hype surrounding CBD is real and does seem relevant. Though there is still more research needed surrounding the impact and potential side effects of CBD, anecdotal evidence and early-stage studies have shed some positive light. If you are curious about using CBD and aren’t sure where to start, begin with a reliable source. Always turn to third-party lab test results to ensure the quality, potency and purity of your CBD product. Choose independent companies with labs like Real Tested CBD to explore which CBD products have tested accurately to label claims and serve best for you.

CBD seems to be popping up everywhere claiming to cure every illness under the sun, but does it really work and if so how? Sometimes it can feel like a modern version of the snake oil salesman and I must admit I was skeptical.  After many recommendations from friends and a big interest from my community, I decided to give it a try and I am excited to share my experience after 8 weeks of consistent use

What Is CBD & How Does it Work?

CBD (short for Cannabidiol) is one of more than a hundred phytocannabinoids, which is unique to cannabis and provides benefits to the body through the endocannabinoid system. Cannabinoids are chemical compounds that interact with your biological processes to produce a desired effect.

So how does CBD work in your body? Your Endocannabinoid System (ECS) works to balance all your body’s functions and the phytocannabinoid CBD can help to replenish deficiencies due to stress and inflammation. Learn more about CBD Basics

A common misconception is that taking CBD can lead to being “high”. Hemp derived CBD products only contain trace amount of THC, which help amplify the therapeutic benefits.

Want to learn more about CBD? Check out this article from the WHO showing that CBD is non-habit forming and safe for consumption.

This article from Project CBD also provides a great science background on CBD.

How to Choose a High-Quality CBD

Just like the food you eat, CBD quality is key! I highly suggest you do your research and talk to your doctor before taking any supplement.

When looking for high-quality CBD you want to ensure the product is third-party lab tested, to ensure it is free from heavy metals and harmful pesticides and you want a full spectrum CBD with a tiny amount of THC, which makes it more effective.

What Did I Hope to Gain with CBD?

I started taking the CBD in mid-May and like many of you my anxiety had been at an all-time high. While I am on low-dose anxiety medication and have been for many years, I was excited to see if the CBD could help regulate my moods. I knew very well that CBD could not eliminate my anxiety, but I was curious to see if it could help with the peaks and valleys of tension and stress that at the time were consuming me daily!

My CBD Dosing

Keep in mind that your dosage will be customized to your body, and your needs and can take up to 3 months to see the full effects. It took me about 2 weeks to find a good routine/dose that worked best for me.

8:30am: 1 – 25mg full spectrum soft gel with my coffee. The gel is a slow release and meant to slowly balance you throughout the day. * I started on the 10mg and worked up to the 25mg 

Side Note: They did suggest taking the capsules with a fatty food for better absorption, which I was doing until I recently switch back to intermittent fasting.

5:00pm – 1/2 dropper (5mg/0.5ml) Daily Drops, pre witching hour, or as needed to manage peaks and valleys of stress. I find the time when I transition from my day job to #momlife + blog life can be most stressful

Bedtime: 3/4 dropper (7mg/0.75ml) daily Drops before bed split into two doses to more easily absorb under my tongue. Letting it absorb vs. swallowing right away helps it absorb into your bloodstream quicker AND it tastes a little less gross. Cannabis has a distinct taste that reminds me of a medicinal herb, but it’s nothing awful.

Episodic Dose: You can also use your drops episodically as needed. So, if I find myself feeling particularly overwhelmed or anxious, or I know I’m headed into a stressful situation, I will do a 1/2 dropper (5mg/0.5ml) of the Daily Drops.

Science Tip: The drops under the tongue are absorbed and take effect faster but are quicker to leave your body so that is why they work for episodic stress. The capsules on the other hand have a slower onset but have a lasting effect throughout the day.

Did CBD Work for Me?

YES! Despite my skepticism, the consistent addition of CBD to my routine has made a big difference in both my anxiety levels and how quickly I am able to wind down for bed at night.

In order to share more than just my anecdotal experience, I decided to track my stress factors for the first 7 days of my CBD experience.

Stress manifests for me as:

  • So many to-do lists/post-its
  • Uncontrolled screen-time
  • Throwing myself into work (particularly the blog)
  • Excessive multi-tasking
  • Racing heart rate

Here are my results for the first 7 days of CBD use

  • Day 1: 5/5 predictors present
  • Day 2: 5/5 predictors present
  • Day 3: 4/5 predictors present
  • Day 4: 1/5 predictors present
  • Day 5: 0/5 predictors present
  • Day 6: 0/5 predictors present
  • Day 7: 0/5 predictors present

Do I still have rough days? Absolutely! But the way I know the CBD is working is that if I miss a day, I immediately notice I am more irritable, more controlled by my anxiety and quicker to snap at family and friends. It’s such a gradual balancing that leaves me feeling like the best version of myself!

 Each person’s experience will be unique. Like any supplement you should consult with your doctor before use and keep in mind that results may take up to 3 months to be evident.

We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

We are often faced with our own personal conflicts which directly influence our interactions with our peers and family. 

When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.

Everyone is trying to get better sleep today, and there is no shortage of products that promise to help ease you into deeper slumber, from weighted blankets to fancy sound machines. But more and more people are adding CBD to their sleep checklist as well.

city and different bed each night, the drummer started to look for more “natural ways to wind down.” That’s when he discovered CBD.

“I used to have trouble with sleep,” Barker tells Rolling Stone, “And I would take a ton of melatonin, valerian tea, Tylenol PM, or Nyquil,” he admits, “but CBD was like the best kind of result that I got.”

The immediate benefits that Barker found with CBD led him to create Barker Wellness, a new line of cannabinoid-infused products that includes a unique CBD tincture for sleep. While CBD is not a medically approved solution for sleep, experts say a little CBD could go a long towards promoting more soothing, stress-free slumber.

How Does CBD Work for Sleep?

“CBD is a compound that supports a powerful, yet widespread network of receptors in the body called the endocannabinoid system (ECS), which is known to help regulate energy, mood, sleep, and more,” explains Dr. Jason Wersland, Founder and Chief Wellness Officer of Therabody, the newly rebranded company that now includes the popular Theragun percussion devices. “Researchers have found that CBD, found naturally in the hemp plant, interacts with ECS receptors throughout the body much like molecules the body naturally produces.”

Experts say the best CBD products for sleep also help you wind down by addressing some of the root causes of restlessness and stress.

“Most people don’t realize the quality of sleep is closely related to stress and maintaining a strong immune system, and you need both systems properly in check if you want an optimal immune response to anything,” adds Jay Hartenbach, CEO of CBD brand Medterra. “If your cortisol levels are elevated, it can keep you awake. CBD is thought to decrease this and keep your body in a homeostasis state.”

If you’re just easing into CBD, Hartenbach suggests finding CBD products that also contain other ingredients that work together to help you feel more restful and relaxed. “CBD, amino acids, L-theanine and 5-HTP, and relaxing herbs like passion flower, chamomile, and lemon balm have each individually been shown to help with providing a full restful night and have been expertly formulated to work together for desired results to address the most common issues,” Hartenbach says. “Proper sleep and circadian control are absolutely essential to an optimally functioning immune system. If your body lacks restful sleep, so does your immunity.”

Will CBD for Sleep Make You Drowsy or High?

The best CBD for sleep is designed to help you ease into slumber – not knock you out. And unlike THC, which may have some psychoactive effects, Wersland says “CBD is non-intoxicating and will not make you feel high.”

If you’re new to CBD, trying a CBD gummy for sleep is an easy way to test out its effects in an easy-to-take format (basically like a gummy bear or gummy vitamin). Many brands also have flavorless CBD oils (or “CBD tinctures”), which come out of a dropper, letting you control exactly how much you want to take. Wersland’s suggestion: start small and then see how the tincture affects you. “If you’d like to take one full dropper that’s 33mg of full-spectrum CBD you can,” he says, “or you can take a ¼ of a dropper which is about 8mg of CBD.”

Of course, CBD is primarily meant for therapeutic benefits and is not meant to replace any doctor-recommended prescriptions if you suffer from serious insomnia. You should also see a doctor if you have a severe sleep disorder, restlessness or anxiety, as CBD is not meant to treat those issues.

A recent clinical trial has identified potential therapeutic benefits of cannabigerol (CBG), a cannabinoid that has not been as widely studied as THC or CBD.

The study, conducted by researchers at Washington State University (WSU) and the University of California, Los Angeles (UCLA), indicates that CBG may significantly reduce anxiety and stress, and could also improve memory.

Published in the journal Scientific Reports, the research involved a double-blind, placebo-controlled field trial with 34 healthy adults.

Participants received either 20mg of hemp-derived CBG or a placebo tincture over two sessions. They completed online assessments before and after taking the cannabinoid, including surveys on anxiety and stress, as well as verbal memory tests.

The study found that CBG led to “significant overall reductions in anxiety as well as reductions in stress” compared to the placebo. Additionally, participants who took CBG showed enhanced verbal memory, which the researchers noted was “completely, entirely unexpected.”

“The finding that it significantly enhanced [memory] was kind of shocking to me and completely, entirely unexpected, which was why I triple-checked the direction and the result,” Cuttler added.

Future Research Directions: What’s Next for CBG?

Cuttler stressed that while the results are promising, further research is needed to confirm these findings and explore CBG’s full range of effects. “Replication and further research are crucial,” she said.

The trial’s results were informed by a prior survey in which 51% of CBG users reported using CBG to alleviate anxiety, with nearly 80% finding it more effective than traditional anxiety medications.

Cuttler is seeking approval for a follow-up clinical trial to be conducted in a laboratory setting to verify these findings and assess CBG’s physiological impacts. She is also exploring potential research on CBG’s effects on menopause symptoms.

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I hope this information was helpful and informative. If you have any more questions, please feel free to ask me. 😊

Inspirational Technologies – IT is Time

We, at Inspirational Technologies are at the forefront of Inspirational and Frontrunners on the frontier of current technology.

We are often faced with our own personal conflicts which directly influence our interactions with our peers and family. 

When Inspirational Technologies is an endorsement of the “Cannabis” approach to the medical condition, we say, let’s let the look at the data and the people who say that they benefit for cannabis alternatives.

Steven M Smith InspirationalTech.org CEO since 2013.

Thank you for consideration.

Inspirational Technologies
InspirationalTech.org for your Health Wellness Beauty and Inspirational Goals

For More Information on Cannabis and CBD and YOU.

AllRightsReserved2024

1st Hemp USA News is a resource of Inspirational Technologies (2024)
Continue reading What Is CBD & How Does it Work?
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