Noteworthy Inspirations - Inspirational Technologies

Posted on 09/20/202111/16/2021 by Steven M Smith — Leave a comment

Current State Of CBD and Cosmetics in the USA

Although the current state of regulation for CBD is in-flux for supplement and food products, the outlook is pretty good for beauty, as long as companies are careful about where they source the CBD, otherwise adhere to the regulations governing the marketing of cosmetic products, and limit sales to states where the sale of such products is legal.

While CBD Infused Beverages and Food Remains with the FDA. Cosmetic Use Is An Open Market Soon To Be Saturated.

CBD, or Cannabidiol, is one of many cannabinoids found in the plant species Cannabis sativa L., which, surprising to many, includes marijuana and hemp.

December 2018 – The Farm Bill Legalized Hemp

The 2018 Farm Bill defines hemp as any part of the plant Cannabis sativa L. with a THC concentration of not more than 0.3% on a dry weight basis, and removes hemp and hemp derivatives from Schedule I of the Controlled Substances Act. CBD derived from a marijuana plant, or from a hemp plant with a THC concentration of greater than 0.3%, fall outside the statutory definition of hemp and therefore remain controlled substances. In order to legally market beauty products containing CBD, companies must be able to establish that the ingredient is derived from a hemp plant, grown by a licensed grower, and contains 0.3% or less THC. The United States Department of Agriculture, the regulatory agency responsible for implementing the 2018 Farm Bill, issued a legal opinion confirming that states may not prohibit the interstate transportation of hemp or hemp derived products that satisfy these requirements.

The Farm Bill does not, however, supplant the Food, Drug and Cosmetics Act (“Act”). Under the Act, companies that want to market beauty products containing CBD cannot claim the products, or the CBD, is intended to affect the structure or function of the body, or otherwise treat, mitigate, or prevent a disease. In addition to these Federal regulatory requirements, companies must also adhere to the laws of individual states, which have the right to restrict or limit the sale of CBD products within their jurisdictions. Thus, before shipping a CBD beauty product, companies should confirm the sale of such products is legal in the target state.

Nikki Fried -Florida Agriculture Commissioner 2021

Why is it crucial for CBD brands and ingredients providers to be completely up to date on the fast-changing regulations? The fast-changing regulations really have to do with growing and licensing requirements for hemp growers. The regulation of what constitutes legal hemp is pretty much set by the 2018 Farm Bill. Since CBD derived from hemp is the only ingredient that has been legalized by the Bill, it is critical for companies and ingredient suppliers to be sure (1) the hemp is sourced from a licensed grower, and (2) the THC content is 0.3% or lower.

3rd Party Certificates Of Analysis (COA) determine what is in the sample tested. Look for the Good and the Bad. *Pesticides, Heavy Metal or Added Toxins. COA’s are a necessity.

Products that fail to meet these two requirements fall outside the statutory definition of hemp, fall within the definition of marijuana under the Controlled Substances Act, and are thus illegal.

Companies interested in marketing and selling CBD cosmetic products will gain insights into the regulatory landscape surrounding the marketing of such products, and in particular, have an understanding of the FDA’s and FTC’s current thinking and approach to regulating the products. Research strategies companies can follow to avoid attracting the attention of regulators and consumer lawyers. What is the number one question that CBD beauty professionals have? There are really two questions to answer. The first is can we legally sell cosmetics containing CBD? The second question is what can I do to protect the company from claims arising from the sale of CBD beauty products. As noted in response to question 1) above, the question of legality is somewhat straightforward. The question of protection is more complex, and involves the need contract with vendors, secure insurance coverage, and consider a myriad of other business considerations.

House Appropriations Committee to Consider Hemp Guidelines this Summer.

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Posted on 08/28/202112/20/2021 by Steven M Smith — Leave a comment

Billionaire – Charles Koch, On Why Now Is The Time For Marijuana Legalization

Billionaire Charles Koch On Why Cannabis Should Be Legal

Charles Koch The same devout libertarian known for spending a fortune on political causes is now being the same actively funding efforts to end federal marijuana prohibition.

Here’s why pro-pot advocates in both parties are high on his support.

Soon, Koch might be known as the billionaire who persuaded Republican and Democratic holdouts to legalize cannabis at the federal level.

“2022, Will Be Our Year To Watch For Legalization Interests To Grow” – Steven Smith, 1st Hemp USA News

Koch admits that he is not on the front lines fighting for legalization—Brian Hooks, the CEO of Stand Together (which Koch founded) and Koch Industries’ former longtime general counsel Mark Holden, and others, are doing the boots-on-the-ground work.

“For far too long, drug policy has been mischaracterized as something that’s come from the fringes,” Hooks says “When in fact the majority of Americans, for a long time, have recognized that a new place for the system is wrong.”

Also, Valerie Jarrett, who was a senior advisor to President Obama, worked with Mark Holden on legislation to reduce mandatory minimum sentencing for nonviolent drug offenders.

The legislation garnered support of 80 senators, but Mitch McConnell, who was Senate Majority Leader at the time, blocked it from reaching the floor in 2016.

Two years later, under President Trump, The First Step Act passed.

Jarrett says that the criminal justice reform would not have passed without Koch’s support.

“That’s how you get things done in Washington—it might mean you have strange bedfellows,” she says.

More than anything, Koch sees marijuana legalization as the beginning of the end of the federal war on drugs.

Here, the modern philosopher king looks to a 19th-century French

economist for wisdom. “For a law to be respected,” Koch says, paraphrasing Frédéric Bastiat, “it must be respectable.”

Market Based Management.”

The push for federal cannabis legalization has been growing slowly over the years, but now that several of the country’s biggest billionaires are on board, that dream may soon become a reality.

Charles Koch, the 85-year-old CEO of Koch Industries, is the latest multibillionaire to help fund the movement to end federal cannabis prohibition once and for all. In a recent interview with Forbes, Koch announced his support for a new plan to end federal weed prohibition by the end of this year. And to help that effort succeed, Koch is contributing $25 million of his $45 billion fortune.

It may come as some surprise to discover that Koch is an advocate of legalization, especially since the billionaire has already spent a fortune backing Republican politicians and lobbying for conservative legislation. Koch is a diehard libertarian, though, and fully opposes the idea that the government could lock someone away in jail just for smoking a joint or otherwise enjoying their own personal freedom.

“It should be the individual’s choice,” Koch said: ‘this’ is counterproductive. It ruins people’s lives, creates conflict in society and is anti-progress. The whole thing never made sense to me… Marijuana, as I understand it, is less addictive than alcohol.

However, it’s unclear whether the long-awaited federal legalization bill, a draft of which Sens. Chuck Schumer, Cory Booker and Ron Wyden introduced in July, can get the 10 Republican senators and all 50 Democratic senators needed to pass it. Schumer readily admits he doesn’t yet have the numbers and President Biden does not support legalization. For politicians on both sides of the aisle who still oppose cannabis, Koch has two questions:

“If you don’t like marijuana, or don’t like people doing that, and you have all these laws, how’s that working out for you?” he asks, before making his second point: “Marijuana, as I understand it, is less addictive than alcohol. So why is alcohol legal and marijuana isn’t?”

So why is alcohol legal and marijuana isn’t?”

Koch sees marijuana legalization as the beginning of the end of the federal war on drugs

“2022, Will Be Our Year To Watch For Legalization Interests To Grow” – Steven Smith, Founder 1st Hemp USA News

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Posted on 08/23/202108/23/2021 by Steven M Smith — Leave a comment

180 Life Sciences Corp. has selected a lead synthetic CBD analogue that is expected to move forward in clinical development.

MENLO PARK, Calif., July 28, 2021 180 Life Sciences Corp, a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain, announced today that it has selected a lead Synthetic CBD Analogue that is expected to move forward in clinical development for both inflammation and pain.

As part of a continuing collaboration since 1998 with the pioneer of cannabis chemistry, Raphi Mechoulam (Hebrew University, Jerusalem), Sir Marc Feldmann’s (the Company’s Co-Executive Chairman and Co-Founder) laboratory, and 180 Life Sciences’ scientists, identified the non-psychoactive CBD analogue as a lead molecule in the Company’s SCA platform.

The analog was selected based on a wide-ranging screen of derivatives of cannabidiol and cannabigerol made by Prof Mechoulam.

The Company believes that the analog appears to have (1) a novel composition of matter which would enable patent protection, (2) robust preclinical efficacy in several established mouse models for treating pain and inflammation in vivo , and (3) ease of scalability for future good manufacturing practice (GMP) manufacturing. Its safety profile is being explored in greater detail.

Dr. James Woody, 180 Life Sciences’ Chief Executive Officer, stated, “We believe that our lead compound HUM-217, a CBD derivative generated by cannabis chemistry pioneer Prof Raphael Mechoulam, meets all the criteria desirable to advance to clinical development. We look forward to continuing to pursue new therapeutics for one of the world’s largest drivers of disease, Inflammation.”

Prof Sir Marc Feldmann, 180 Life Sciences Executive Co-Chairman added, “It is a real pleasure to announce the progress that has been made, which we believe is a significant step forward towards the more effective use of pure synthetic cannabinoids in medicine. We look forward to continuing the development of these compounds in clinical trials.”

*About 180 Life Sciences Corp. 180 Life Sciences Corp. is a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. 180 Life Sciences is leading the research into solving one of the world’s biggest drivers of disease – inflammation. The Company is driving groundbreaking studies into clinical programs, which are seeking to develop novel drugs addressing separate areas of inflammation for which there are no effective therapies. The Company’s primary, most advanced platform is a novel program to treat fibrosis using anti-TNF (tumor necrosis factor) which is in the clinic.

180 Life Sciences Corp

Posted on 08/10/202112/18/2021 by Steven M Smith — Leave a comment

CBD Honey? No Really, May Bee the Solution.

“Hemp is a high pollen producing crop flowering during a period of floral resource scarcity and supports a diverse array of bees in the northeastern U.S. landscape.”

Search more images of Honey bee

In a new study published in the journal Environmental Entomology, researchers in the Department of Entomology at Cornell University in New York wondered if the growing legalization of cannabis for recreational, medical and industrial purposes is having any effect on bees.

See the source image

While marijuana is becoming in New York, industrial hemp is a fast-growing industry and the flowers are essentially the same. In a simple test (repeat visits to New York hemp farms and collected bees with nets), the researchers found 16 different bee species happily buzzing around the buds.

That variety highlights the “species richness” of Cannabis sativa when it comes to attracting bees.

“Industrial hemp offers a unique floral resource to bees in agricultural landscapes. Hemp flowers late in the summer releasing an abundance of pollen during a period of native and agricultural floral dearth. As a result, hemp pollen may offer a vital subsistence resource to bees at a point in the season when they are resource-limited, thereby helping to alleviate the pressures imposed by spatial and temporal variation in resource availability that is characteristic of simplified agricultural landscapes.”

The researchers weren’t as concerned about the growing creation of cannabis honey (we know you are – hang on) as much as how the dominance of cannabis would affect the bees.

It turns out that besides being attractive to a diversity of bees, cannabis blossoms in the late summer when most other plants are finished and bees are looking for pollen. By extending their season, cannabis may actually be helping to strengthen the bees to fight off the diseases that have decimated their populations in recent years. What about the cannabis honey?

Right.

Most products labeled cannabis honey are actually infused with CBD or THC.

While beekeepers claim the honey from bees specializing in cannabis flowers contains cannabinoids, it’s tough to differentiate between benefits that might come from them and the natural benefits of honey.

The Israeli cannabis technology company PhytoPharma International is offering pure, non-infused, highly bioavailable cannabis-derived honey called Pure Bee.

It’s available in two forms — non-intoxicating CBD Honey and psychoactive THC Honey – and is said to take effect in 10 minutes, much faster than most edible cannabis products.

So, do bees really get a buzz from marijuana? Unfortunately, no. Bees lack cannabinoid receptors and merely pass them on to their honey.

They buzz the buds merely for the fun and the exercise.

That’s just another good reason to be kind to bees.

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Posted on 08/06/202108/06/2021 by Steven M Smith — Leave a comment

Six Steps To Better Sleep

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SIX WAYS TO BETTER SLEEP

If you’re like one of the millions of Americans who struggle to get restful sleep, consider implementing these steps into your bedtime routine. Hempsmart Smart Drops are a great addition to your sleep routine, helping you achieve more restorative sleep and overall well-being. hempsmart™ hempsmart™ hempsmart™ is committed to using only the highest quality all-natural ingredients, cutting edge science-based formulations, and premium broad-spectrum hemp extracts in therapeutic amounts to formulate our product-lines with a sophistication and effectiveness beyond compare. It is our goal to help transform personal health into planetary health.

If you’re like one of the millions of Americans who struggle to get restful sleep, consider implementing these steps into your bedtime routine.

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It is our goal to help transform personal health into planetary health.

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Posted on 07/01/202107/02/2021 by Steven M Smith — Leave a comment

Glutathione Benefits Medically reviewed by Debra Rose Wilson, Ph.D.,

Glutathione Benefits Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT — Written by Corey Whelan — Updated on September 18, 2018 Glutathione benefits Forms Side effects and risks Takeaway Overview Glutathione is an antioxidant produced in cells. It’s comprised largely of three amino acids: glutamine, glycine, and cysteine. Glutathione levels in the body may be reduced by a number of factors, including poor nutrition, environmental toxins, and stress. Its levels also decline with age. In addition to being produced naturally by the body, glutathione can be given intravenously, topically, or as an inhalant. It’s also available as an oral supplement in capsule and liquid form. However, oral ingestion of glutathione may not be as effectiveTrusted Source as intravenous delivery for some conditions.

Glutathione benefits

1. Reduces oxidative stress Oxidative stress occurs when there’s an imbalance between the production of free radicals and the body’s ability to fight them off. Too-high levels of oxidative stress may be a precursor to multiple diseases. These include diabetes, cancer, and rheumatoid arthritis. Glutathione helps stave off the impact of oxidative stress, which may, in turn, reduce disease. An article cited in Journal of Cancer Science and Therapy indicated that glutathione deficiency leads to increased levels of oxidative stress, which might lead to cancer. It also stated that elevated glutathione levels raised antioxidant levels and resistance to oxidative stress in cancer cells.

2. May improve psoriasis A small studyTrusted Source indicated that whey protein, when given orally, improved psoriasis with or without additional treatment. Whey protein had been previously demonstrated to increase glutathione levels. Study participants were given 20 grams as an oral supplement daily for three months. Researchers stated that more study is needed.

3. Reduces cell damage in alcoholic and nonalcoholic fatty liver disease Cell death in the liver may be exacerbated by a deficiency in antioxidants, including glutathione. This can lead to fatty liver disease in both those who misuse alcohol and those who don’t. Glutathione has been shown to improve protein, enzyme, and bilirubin levels in the blood of individuals with alcoholic and nonalcoholic chronic fatty liver disease. A studyTrusted Source reported that glutathione was most effective when given to people with fatty liver disease intravenously, in high doses. Participants in the study also showed reductions in malondialdehyde, a marker of cell damage in the liver. Another small studyTrusted Source found that orally administered glutathione had positive effects on people with nonalcoholic fatty liver disease following proactive lifestyle changes. In this study, glutathione was provided in supplement form in a dose of 300 milligrams per day for four months.

4. Improves insulin resistance in older individuals As people age, they produce less glutathione. Researchers at Baylor School of Medicine used a combination of animal and human studies to explore the role of glutathione in weight management and insulin resistance in older individuals. Study findings indicated that low glutathione levels were associated with less fat burning and higher rates of fat storing in the body. Older subjects had cysteine and glycine added to their diets to increase glutathione levels, which spiked within two weeks, improving insulin resistance and fat burning.

5. Increases mobility for people with peripheral artery disease Peripheral artery disease occurs when the peripheral arteries become clogged by plaque. It most commonly happens in the legs. One study reported that glutathione improved circulation, increasing the ability of study participants to walk pain-free for longer distances. Participants receiving glutathione rather than a saline solution placebo were given intravenous infusions two times daily for five days, and then analyzed for mobility. 6. Reduces symptoms of Parkinson’s disease Parkinson’s disease affects the central nervous system and is defined by symptoms such as tremors. It currently has no cure. One older study documented intravenous glutathione’s positive effects on symptoms such as tremors and rigidity. While more research is needed, this case report suggests that glutathione may help reduce symptoms, improving quality of life in people with this disease.

7. May help fight against autoimmune disease The chronic inflammation caused by autoimmune diseases can increase oxidative stress. These diseases include rheumatoid arthritis, celiac disease, and lupus. According to one studyTrusted Source, glutathione helps reduce oxidative stress by either stimulating or reducing the body’s immunological response. Autoimmune diseases attack the mitochondria in specific cells. Glutathione works to protect cell mitochondria by eliminating free radicals.

8. May reduce oxidative damage in children with autism Several studiesTrusted Source, including a clinical trial reported in Medical Science MonitorTrusted Source, indicate that children with autism have higher levels of oxidative damage and lower levels of glutathione in their brain. This increased susceptibility to neurological damage in children with autism from substances such as mercury. The eight-week clinical trial on children aged 3 to 13 used oral or transdermal applications of glutathione. Autistic symptom changes were not evaluated as part of the study, but children in both groups showed improvement in cysteine, plasma sulfate, and whole-blood glutathione levels.

9. May reduce the impact of uncontrolled diabetes Long-term high blood sugar is associated with reduced amounts of glutathione. This can lead to oxidative stress and tissue damage. A study found that dietary supplementation with cysteine and glycine boosted glutathione levels. It also lowered oxidative stress and damage in people with uncontrolled diabetes, despite high sugar levels. Study participants were placed on 0.81 millimoles per kilogram (mmol/kg) of cysteine and 1.33 mmol/kg glycine daily for two weeks.

10. May reduce respiratory disease symptoms N-acetylcysteine is a medication used to treat conditions such as asthma and cystic fibrosis. As an inhalant, it helps to thin mucus and make it less paste-like. It also reduces inflammation. N-acetylcysteine is byproduct of glutathione.

Glutathione is found in some foods, although cooking and pasteurization diminish its levels significantly. Its highest concentrations are in: raw or very rare meat unpasteurized milk and other unpasteurized dairy products freshly-picked fruits and vegetables, such as avocado, and asparagus.

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Glutathione contains sulfur molecules, which may be why foods high in sulfur help to boost its natural production in the body. These foods include: cruciferous vegetables, such as broccoli, cauliflower, Brussels sprouts, and bok choy allium vegetables, such as garlic and onions eggs nuts legumes lean protein, such as fish, and chicken Other foods and herbs that help to naturally boost glutathione levels include: milk thistle flaxseed guso seaweed whey Glutathione is also negatively affected by insomnia. Getting enough rest on a regular basis can help increase levels. Side effects and risks A diet rich in glutathione-boosting foods does not pose any risks. However, taking supplements may not be advisable for everyone. Talk to your doctor about glutathione to determine if it’s right for you. Possible side effects may include: abdominal cramps bloating trouble breathing due to bronchial constriction allergic reactions, such as rash Takeaway Glutathione is a powerful antioxidant that’s made in the body’s cells. Its levels decrease as a result of aging, stress, and toxin exposure. Boosting glutathione may provide many health benefits, including reduction of oxidative stress.

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Current State Of CBD and Cosmetics in the USA

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Billionaire – Charles Koch, On Why Now Is The Time For Marijuana Legalization

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180 Life Sciences Corp. has selected a lead synthetic CBD analogue that is expected to move forward in clinical development.

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CBD Honey? No Really, May Bee the Solution.

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Six Steps To Better Sleep

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