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Posted on 11/07/202111/07/2021 by Steven M Smith — Leave a comment

Planting The Seeds of CDB . . .

An entire industry is being built around cannabidiol, or CBD,

one of the many chemical constituents of the cannabis plant.

A message from the Founder of “Inspirational Technologies

Inspirational Technologies – Steven Smith 2021 In this Blog, “Planting the Seeds of CBD . . .”, we wish to Inspire those who are still waiting for the process of “Legitimizing the Claims of CBD” and “MOVE the CHAINS” forward in the game of CBD. We have had patience, waited on government regulators and Pilot Hemp Programs to give framework to the farmers, cultivators and processing plants. Thank you for your participation, Steven M Smith, Owner/Founder, Inspirational Technologies.

Advocates of the compound say it confers all sorts of health benefits,

from mitigating the symptoms of depression and anxiety to treating Glaucoma,

It’s cropping up in protein powders, bath salts, makeup and even jelly beans.

Medical Advisory Groups for Corporate Subsidiaries are critical for US FDA CBD Compliance

But scientists are still unsure of exactly what the benefits — and pitfalls — of CBD are.

“Society has jumped way ahead of the science on this,” said Margaret Haney,

a professor of neurobiology at Columbia University Medical Center in New York.

Reported benefits have mostly been anecdotal, or they have come from studies involving animal models.

CBD isn’t well understood, nor have there been sufficient studies done in humans, she said.

Cannabis plants produce a group of chemical compounds called cannabinoids.

The best-known are tetrahydrocannabinol, or THC

(the so-called psychoactive component of the plant that’s associated with the marijuana “high”),

and CBD (a non-intoxicating component of the plant that doesn’t produce a high),

Hemp. Recently, Legal to grow and process for CDB.

Here’s what we do know: CBD can help treat some types of pediatric seizures.

Last year, the FDA approved GW Pharmaceuticals PLC’s Epidiolex for the treatment of seizures associated with two rare forms of epilepsy in patients two years of age and older.

But, to get to that point, GW Pharmaceuticals had to go through a long and rigorous drug-approval process to show the drug’s safety and efficacy through clinical trials.

T his hasn’t been done with CBD for any other indication, until now.

While it’s true that CBD has shown promise in pre-clinical and animal trials in addressing a number of issues such as pain, anxiety, neuroinflammation and substance-use disorder,

there’s still not nearly enough peer-reviewed research available, said Ziva Cooper, research director of the Cannabis Research Initiative at the University of California, Los Angeles.

To truly determine the effects of CBD in humans, many further studies need to be done — studies with humans, she said. “Overall, we have very little real data on the therapeutic effects of cannabidiol,” she said.

As for those CBD-based skin products that are popping up on shelves and online, Columbia University’s Haney said she remains skeptical of their marketed benefits.

Many are diluted. It’s a question of both dosage and absorption, she said. “We have no idea how much CBD you would need to rub on your skin for it to have some kind of medical effect,” she said.

The amount of CBD in a lot of marketed products — even ones that are meant to be taken orally — is so small that we can not make any therapeutic measures for the person using it, said UCLA’s Cooper.

In the few studies that have involved humans, doses were in the hundreds of milligrams, but most CBD-infused products contain much less than that,

which the company says can be used as a daily supplement and help “promote a calm sense of well-being,” it also notes on its website that such statements “have not been evaluated by the Food and Drug Administration.”

CBD advocates were hoping laws around the compound might loosen up — or at least become clearer — after President Donald Trump signed the 2018 Farm Bill.

Mature Hemp Field Crop — Hemp Is Now A Viable Agriculture Phenomenon

The bill legalized hemp, a variety of the cannabis plant that contains no more than 0.3% THC.

December 2018 – The Farm Bill Legalized Hemp

But regulation of CBD, whether derived from hemp or not, is still largely under the FDA’s jurisdiction.

Since CBD is technically an active ingredient in an FDA-approved drug,

companies are not allowed to add it to food or drinks sold across state lines or to sell it as a dietary supplement.

Companies are, however, allowed to put the compound into beauty and skin-care products, as cosmetics are not subject to premarket approval by the FDA.

That could explain why drugstore chains like CVS and Walgreens aren’t worried about introducing CBD-infused topical products in their stores.

“People shouldn’t confuse availability with legality,” said former FDA regulatory counsel Jonathan Havens.

The agency has cracked down on unfounded claims, but it has limited resources and can’t get to everyone, so it is focusing mostly on companies making blatant health claims about their products, Havens said.

The FDA recently sent warning letters to Advanced Spine and Pain LLC, Nutra Pure LLC and PotNetwork Holdings,

saying the companies violated federal law by advertising their CBD-containing products as potential treatments for ailments including cancer, Alzheimer’s disease, arthritis and more.

“The FDA wants to protect consumers. The last thing it wants is companies out there marketing CBD products and claiming health benefits without any clinical rese arch to validate that,”

said Rob DiPisa, co-chair of the Cannabis Law Group at law firm Cole Schotz.

US FDA Fight to Regulate Cannabis (Hemp) More Research is Needed

At the same time, requiring anyone who wants to put a CBD-containing food or beverage on the market to go through the clinical-trial process would “chill the whole CBD market,” he said.

The FDA is aware of the public’s interest in CBD. Former FDA commissioner Scott Gottlieb put out a statement outlining steps to figure out a framework to lawfully market cannabis

and cannabis-derived products, including public hearings and formed an internal working group to look into the issue.

DiPisa said he hopes the hearings last May 2021 will provide more clarity for him and his clients.

“Everyone is running blind right now,” he said.

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Posted on 09/30/202109/30/2021 by Steven M Smith — Leave a comment

Cannabis Global Awarded Trademark for its Comply Bag(R) Cannabis Transport and Tracking System

Watching Florida's Stop Light on Marijuana

LOS ANGELES, CA September 30, 2021 Cannabis Global, an innovation-oriented company investing in disruptive cannabis and hemp-related technologies,

today announces it has been awarded a trademark on “Comply Bag®” from the United States Patent and Trademark Office.

Comply Bag® product is the integration of ultra-secure and tamper-evident cannabis transport technology and a smartphone-based tracking app that allows both the shipper and intended receiver of cannabis to monitor the progress of the valuable commodity all the way from the origination to the final destination.

Mr. Arman Tabatabaei, CEO of Cannabis Global commented, “While cannabis is becoming a big business, the transportation of products is still stuck in practices established well before selective state legalization

Comply Bag® offers unparalleled safety, security, traceability, compliance, and cannabis data integration.”

The Company has a new video outlining the product, which can be viewed at Ship Safe and Track with Comply Bag.

Comply Bag® features a multi-layer, low-density polyethylene outer shell that protects valuable shipments and allows manufacturers, buyers, and processors full view of contents to assess quality.

Each Comply Bag® contains financial institution-grade tamper-evident seams, self-sealing closures, and sequential numbering to ensure what is sent is what is received.

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Posted on 09/23/202109/23/2021 by Steven M Smith — Leave a comment

Florida Black Farmers Still Awaiting

TALLAHASSEE, Fla. – September 23, 2021

The Department of Health

is under fire because it has still not issued a medical marijuana license to a Black farmer.

Lawmakers grilled the department to find out what is responsible for the delay on Thursday.

When the Legislature passed its medical marijuana law in 2017,

one grower’s license was reserved for a Black farmer.

“So that the medical marijuana licenses in our state would have equity,”

said state Sen. Darryl Rouson.

Rouson called the Department of Health before the Senate Agriculture Committee

to explain why the Black farmer’s license isn’t among the 22 that have already been issued.

“Years have passed since this Legislature spoke,” said Rouson.

The department blamed the delay on a lawsuit challenging

the state’s seed-to-sale requirement for license holders.

The state Supreme Court finally ruled in the state’s favor in May.

Department of Agriculture (USDA)

“We are working quickly and anticipate moving forward with the Pigford MMTC licensing process in the coming weeks,”

said Christopher Ferguson, director of the Office of Medical Marijuana Use.

Meanwhile, The Florida Black Farmers Wait.

Inspirational Technologies (2021)

Posted on 09/20/202111/16/2021 by Steven M Smith — Leave a comment

Current State Of CBD and Cosmetics in the USA

Although the current state of regulation for CBD is in-flux for supplement and food products, the outlook is pretty good for beauty, as long as companies are careful about where they source the CBD, otherwise adhere to the regulations governing the marketing of cosmetic products, and limit sales to states where the sale of such products is legal.

While CBD Infused Beverages and Food Remains with the FDA. Cosmetic Use Is An Open Market Soon To Be Saturated.

CBD, or Cannabidiol, is one of many cannabinoids found in the plant species Cannabis sativa L., which, surprising to many, includes marijuana and hemp.

The 2018 Farm Bill defines hemp as any part of the plant Cannabis sativa L. with a THC concentration of not more than 0.3% on a dry weight basis, and removes hemp and hemp derivatives from Schedule I of the Controlled Substances Act. CBD derived from a marijuana plant, or from a hemp plant with a THC concentration of greater than 0.3%, fall outside the statutory definition of hemp and therefore remain controlled substances. In order to legally market beauty products containing CBD, companies must be able to establish that the ingredient is derived from a hemp plant, grown by a licensed grower, and contains 0.3% or less THC. The United States Department of Agriculture, the regulatory agency responsible for implementing the 2018 Farm Bill, issued a legal opinion confirming that states may not prohibit the interstate transportation of hemp or hemp derived products that satisfy these requirements.

The Farm Bill does not, however, supplant the Food, Drug and Cosmetics Act (“Act”). Under the Act, companies that want to market beauty products containing CBD cannot claim the products, or the CBD, is intended to affect the structure or function of the body, or otherwise treat, mitigate, or prevent a disease. In addition to these Federal regulatory requirements, companies must also adhere to the laws of individual states, which have the right to restrict or limit the sale of CBD products within their jurisdictions. Thus, before shipping a CBD beauty product, companies should confirm the sale of such products is legal in the target state.

Nikki Fried -Florida Agriculture Commissioner 2021

Why is it crucial for CBD brands and ingredients providers to be completely up to date on the fast-changing regulations? The fast-changing regulations really have to do with growing and licensing requirements for hemp growers. The regulation of what constitutes legal hemp is pretty much set by the 2018 Farm Bill. Since CBD derived from hemp is the only ingredient that has been legalized by the Bill, it is critical for companies and ingredient suppliers to be sure (1) the hemp is sourced from a licensed grower, and (2) the THC content is 0.3% or lower.

3rd Party Certificates Of Analysis (COA) determine what is in the sample tested. Look for the Good and the Bad. *Pesticides, Heavy Metal or Added Toxins. COA’s are a necessity.

Products that fail to meet these two requirements fall outside the statutory definition of hemp, fall within the definition of marijuana under the Controlled Substances Act, and are thus illegal.

Companies interested in marketing and selling CBD cosmetic products will gain insights into the regulatory landscape surrounding the marketing of such products, and in particular, have an understanding of the FDA’s and FTC’s current thinking and approach to regulating the products. Research strategies companies can follow to avoid attracting the attention of regulators and consumer lawyers. What is the number one question that CBD beauty professionals have? There are really two questions to answer. The first is can we legally sell cosmetics containing CBD? The second question is what can I do to protect the company from claims arising from the sale of CBD beauty products. As noted in response to question 1) above, the question of legality is somewhat straightforward. The question of protection is more complex, and involves the need contract with vendors, secure insurance coverage, and consider a myriad of other business considerations.

House Appropriations Committee to Consider Hemp Guidelines this Summer.

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Posted on 08/23/202108/23/2021 by Steven M Smith — Leave a comment

180 Life Sciences Corp. has selected a lead synthetic CBD analogue that is expected to move forward in clinical development.

MENLO PARK, Calif., July 28, 2021 180 Life Sciences Corp, a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain, announced today that it has selected a lead Synthetic CBD Analogue that is expected to move forward in clinical development for both inflammation and pain.

As part of a continuing collaboration since 1998 with the pioneer of cannabis chemistry, Raphi Mechoulam (Hebrew University, Jerusalem), Sir Marc Feldmann’s (the Company’s Co-Executive Chairman and Co-Founder) laboratory, and 180 Life Sciences’ scientists, identified the non-psychoactive CBD analogue as a lead molecule in the Company’s SCA platform.

The analog was selected based on a wide-ranging screen of derivatives of cannabidiol and cannabigerol made by Prof Mechoulam.

The Company believes that the analog appears to have (1) a novel composition of matter which would enable patent protection, (2) robust preclinical efficacy in several established mouse models for treating pain and inflammation in vivo , and (3) ease of scalability for future good manufacturing practice (GMP) manufacturing. Its safety profile is being explored in greater detail.

Dr. James Woody, 180 Life Sciences’ Chief Executive Officer, stated, “We believe that our lead compound HUM-217, a CBD derivative generated by cannabis chemistry pioneer Prof Raphael Mechoulam, meets all the criteria desirable to advance to clinical development. We look forward to continuing to pursue new therapeutics for one of the world’s largest drivers of disease, Inflammation.”

Prof Sir Marc Feldmann, 180 Life Sciences Executive Co-Chairman added, “It is a real pleasure to announce the progress that has been made, which we believe is a significant step forward towards the more effective use of pure synthetic cannabinoids in medicine. We look forward to continuing the development of these compounds in clinical trials.”

*About 180 Life Sciences Corp. 180 Life Sciences Corp. is a clinical-stage biotechnology company focused on the development of novel drugs that fulfill unmet needs in inflammatory diseases, fibrosis and pain by leveraging the combined expertise of luminaries in therapeutics from Oxford University, the Hebrew University and Stanford University. 180 Life Sciences is leading the research into solving one of the world’s biggest drivers of disease – inflammation. The Company is driving groundbreaking studies into clinical programs, which are seeking to develop novel drugs addressing separate areas of inflammation for which there are no effective therapies. The Company’s primary, most advanced platform is a novel program to treat fibrosis using anti-TNF (tumor necrosis factor) which is in the clinic.

180 Life Sciences Corp

Posted on 08/10/202112/18/2021 by Steven M Smith — Leave a comment

CBD Honey? No Really, May Bee the Solution.

“Hemp is a high pollen producing crop flowering during a period of floral resource scarcity and supports a diverse array of bees in the northeastern U.S. landscape.”

Search more images of Honey bee

In a new study published in the journal Environmental Entomology, researchers in the Department of Entomology at Cornell University in New York wondered if the growing legalization of cannabis for recreational, medical and industrial purposes is having any effect on bees.

See the source image

While marijuana is becoming in New York, industrial hemp is a fast-growing industry and the flowers are essentially the same. In a simple test (repeat visits to New York hemp farms and collected bees with nets), the researchers found 16 different bee species happily buzzing around the buds.

That variety highlights the “species richness” of Cannabis sativa when it comes to attracting bees.

“Industrial hemp offers a unique floral resource to bees in agricultural landscapes. Hemp flowers late in the summer releasing an abundance of pollen during a period of native and agricultural floral dearth. As a result, hemp pollen may offer a vital subsistence resource to bees at a point in the season when they are resource-limited, thereby helping to alleviate the pressures imposed by spatial and temporal variation in resource availability that is characteristic of simplified agricultural landscapes.”

The researchers weren’t as concerned about the growing creation of cannabis honey (we know you are – hang on) as much as how the dominance of cannabis would affect the bees.

It turns out that besides being attractive to a diversity of bees, cannabis blossoms in the late summer when most other plants are finished and bees are looking for pollen. By extending their season, cannabis may actually be helping to strengthen the bees to fight off the diseases that have decimated their populations in recent years. What about the cannabis honey?

Right.

Most products labeled cannabis honey are actually infused with CBD or THC.

While beekeepers claim the honey from bees specializing in cannabis flowers contains cannabinoids, it’s tough to differentiate between benefits that might come from them and the natural benefits of honey.

The Israeli cannabis technology company PhytoPharma International is offering pure, non-infused, highly bioavailable cannabis-derived honey called Pure Bee.

It’s available in two forms — non-intoxicating CBD Honey and psychoactive THC Honey – and is said to take effect in 10 minutes, much faster than most edible cannabis products.

So, do bees really get a buzz from marijuana? Unfortunately, no. Bees lack cannabinoid receptors and merely pass them on to their honey.

They buzz the buds merely for the fun and the exercise.

That’s just another good reason to be kind to bees.

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from mitigating the symptoms of depression and anxiety to treating Glaucoma,

Medical Advisory Groups for Corporate Subsidiaries are critical for US FDA CBD Compliance

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