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Scientists Just Learned How CBD Makes Molecules 30x More Effective Than Aspirin. Why Opioids Just Can’t Compete.

Cannabis is a complex plant with a complex history. It’s been cultivated for at least 6,000 years, but because of its modern legal status, we’re still learning new things about its medicinal benefits.While most of us have heard of the plant’s pain-relieving cannabinoids, such as CBD, there’s a lesser known class of compounds that deserves our attention.

Flavonoids are a group of natural substances that are thought to hold anti-oxidative, anti-inflammatory, and anti-carcinogenic properties. These compounds are found in fruits, vegetables, flowers, tea, wine, and, yes, even cannabis.

In 1986, researcher Marilyn Barrett at the University of London was the first to identify two cannabis flavonoids, known as cannflavin A and cannflavin B, both of which were found to have anti-inflammatory benefits 30 times more effective than Aspirin.

But while the flavonoid pathway has been extensively studied in several other plants, for decades, there has been no specific data on their biosynthesis in cannabis. Now, for the first time, researchers in Canada have uncovered how the cannabis plant creates these important pain-relieving molecules.

Our objective was to better understand how these molecules are made, which is a relatively straightforward exercise these days,” explains Tariq Akhtar, a molecular and cellular biologist at the University of Guelph.

“There are many sequenced genomes that are publicly available, including the genome of Cannabis sativa, which can be mined for information. If you know what you’re looking for, one can bring genes to life, so to speak, and piece together how molecules like cannflavins A and B are assembled.”

Using a combination of genomics and biochemistry techniques, the team was able to pinpoint which genes were responsible for creating these two cannflavins. Their findings provide the first evidence of a unique genetic pathway in Cannabis sativa plants, which uses two enzymes to ultimately create cannflavin A and B.

Extracting and purifying these compounds from a cannabis plant, however, just isn’t practical. Akhtar epxlained to The Toronto Star that these cannflavins only make up about .014 per cent of the plant’s weight, so fields and fields of cannabis would have to be grown in order to capture these anti-inflammatory benefits.

As a result, the researchers hope to use this new information to metabolically engineer their own pain-relieving medicine outside of the cannabis plant. To achieve this, they will be working with the Toronto-based company, Anahit International Corp., which has already licensed a patent from their university.

“The problem with these molecules is they are present in cannabis at such low levels, it’s not feasible to try to engineer the cannabis plant to create more of these substances,” says co-author Steven Rothstein, who studies the molecular and genetic qualities of crop plants at University of Guelph.

“We are now working to develop a biological system to create these molecules, which would give us the opportunity to engineer large quantities.”

Without some of the side effects of other painkillers, the authors think the synthesis of these molecules could make a big difference in the pharmaceutical industry.

Previous studies have shown that the vast majority of patients prefer cannabis to opioids when managing their pain, which suggests there’s ample market for a drug that mimics its benefits.

“There’s clearly a need to develop alternatives for relief of acute and chronic pain that go beyond opioids,” says Akhtar.

“These molecules are non-psychoactive and they target the inflammation at the source, making them ideal painkillers.” 

This research has been published in Phytochemistry.

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Numbers Don’t Lie. Florida Medical Marijuana Use reports another record week of cannabis sales ending December 20th, 2019

giphyFlorida Office of Medical Marijuana Use reported another record week of cannabis sales on December 20th, 2019. Record numbers are showing strong growth of medical marijuana sales in the state, and this is expected to continue as the state pushes for recreational cannabis legalization. High THC mg sold jumped up 38%, CBD mg sold jumped 8% from previous week.
Despite strong presence of Trulieve (CSE: TRUL, OTC: TCNNF) operating 42 dispensaries in Florida – see more, Curaleaf Holdings Inc. (CSE: CURA, OTC: CURLF) is also continuing to push out bigger numbers. Curaleaf, a leading vertically integrated cannabis operator in the United States recently announced the opening of its 28 dispensary in Florida. However it wasn’t Trulieve or Curaleaf that had the best sales week, GrowHealthy, subsidiary of iAnthus Capital Holdings (CSE: IAN, OTC: ITHUF) had a Record week of medical marijuana sales. GrowHealthy recorded 135% increase in week over week medical marijuana sales (1.86 million grams to 4.37) and 104% increase in smokable form marijuana.
GrowHealthy

GrowHealthy, recently debuted a brand-new dispensary in Ocala, Florida, on December 12th, 2019 The Florida based brand looks forward to one new additional storefronts this calendar year, preparing for openings in Stuart. The Ocala location will mark GrowHealthy’s 11th retail store, with more than 17 retail locations slated for opening by end of Q1 2020. (News Release)
GrowHealthy plans on opening several additional stores in early 2020 pending regulatory approvals. The Company currently has several additional sites under construction and a total of 11 more under lease.
Florida (THC 38% Increase, CBD 8% Increase – Week Over Week)
Week Dec 6-12, 2019: 74,086,880 (mg THC)
Week Dec 13-19, 2019: 92,934,406 (mg THC)
Patients
Qualified Patients (Active ID Card): 298,659
Total Patients: 421,297
Source: https://knowthefactsmmj.com/2018/12/21/2019-ommu-updates/

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“Inspirational Technologies” Announces New Expansion in “Background Noise “ Studios

“Background Noise” Studios Inspirational Technologies All Rights Reserved 2019

FloridaNewsWire Release

September 10, 2019

Steven Smith, Founder/Owner of Inspirational Technologies, announced, today, the Name of the company’s new endeavor, “Background Noise” Studios. Steven, in a statement said, “My personal goals of our Company are moving in a direction that compliments our mission statement in Building a Studio to Develop, Research, and Promote Audio/Visual and Broadcasting Media Endeavors. This new branch of our Company is an extremely exciting one.” He continued, “We believe the benefits of building a Studio for our continued efforts in developing opportunities for our Company’s move into the Educational and even the Entertainment Industry is paramount to our success strategy.” When asked about the studio’s location, Steven’s response was, “No comment, at this time.” It is believed that it’s location is in Northern Florida.

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Make it Legal Florida “Adult Use of Marijuana” 2020 Ballot Possibilities Put That In Your Pipe and Smoke it!

A new effort to legalize recreational pot in Florida is underway. This time, it’s being backed by the medical marijuana industry.

Recreational could become Reality!

Continue reading Make it Legal Florida “Adult Use of Marijuana” 2020 Ballot Possibilities Put That In Your Pipe and Smoke it!