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Cannabis Global in Definitive Agreement to Acquire Caliwanna

LOS ANGELES, CA March 14, 2022 Cannabis Global, Inc. announces the signing of a definitive agreement between the Company and the owners of Caliwanna brands for comprehensive marketing and sales integration and acquisition of the Caliwanna cannabis brands.

Under the terms of the agreement, the highly experienced Caliwanna marketing team will immediately launch three of Cannabis Global’s cannabis products – edibles, infused prerolls, and live rosin – into the California marketplace.

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In addition, all Caliwanna products will now be sold under the cannabis license owned by Cannabis Global’s majority-owned subsidiaries, Natural Plant Extract of California, and Northern Lights Distribution.

Management of Cannabis Global expects the agreement to result in significant incremental revenue generation beginning immediately.

“This is so much more than just an acquisition of successful cannabis brands, although we are of course excited to begin marketing Caliwanna’s Brands effectively immediately” commented Arman Tabatabaei, CEO of Cannabis Global.

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Arman Tabatabaei, CEO of Cannabis Global.

“In addition to meaningfully expanding our brand footprint, we are also gaining experienced sales and marketing executives via the addition of the principals of Caliwanna to our team.

Caliwanna already sells products in several dozen California cannabis retail establishments. We plan to see our innovative products in this sales channel very quickly.”

 

 

 

 

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Happy St. Patty’s Day – Go Green! Better clothing, better food, better gadgets. Is there anything Hemp can’t do?

Las Vegas, NV, March 15, 2022   Better clothing, better food, better gadgets. .is there anything hemp can’t do?

Today,  the benefits of hemp-based batteries and how a group of American and Canadian researchers used hemp bast fiber (the inner bark of the plant that usually ends up in landfill) to develop a battery that has been used in cars and power tools.

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According to Return to Now, the researchers “cooked the woody pulp and processed them into carbon nanosheets, which they used to build supercapacitors on a par with or better than graphene which is the industry gold standard.”

Image result for graphene. Size: 182 x 160. Source: upload.wikimedia.org

Is this new?

No. But with continued research and development, who knows where hemp will take us in 2022 and beyond.

Before we go back to the future, let’s take a look at how this research team used these fibers and recycled them into supercapacitors.

The woody pulp from the hemp fiber was cooked and processed into carbon nanosheets. These nanosheets are used to build something called supercapacitors.

Supercapacitors are used as energy storage systems. We see these storage systems in the form of batteries that we use to power up different things we use in everyday life.

What we may not know is that “scientists have long struggled developing energy solutions and capacitors that can keep up with the current rate of electronic component evolution.

While we are able to store a large amount of energy in certain types of (non-hemp) batteries, those batteries are very large, very heavy, and charge and release their energy relatively slowly.” 

In reality, hemp batteries are designed to work differently than lithium-ion batteries. Researchers term batteries made from hemp as ‘supercapacitors.’

 

Hemp batteries are referred to as supercapacitors. According to High Grade Hemp Seed, “it’s best to think of a battery-powered car or truck. They need a steady amount of electric energy as they drive down a country road.

However, if that car stops at a red light, the battery will need a big burst of energy when the light turns green to get going again. Lithium-ion batteries are great at storing energy for a long time and expending it slowly.

However, they are not so good at rapidly releasing a large amount of energy, like what a car needs when a red light turns green.” Supercapacitors are good at performing this function. “These types of batteries can discharge their entire load of energy quickly to provide a big boost of energy. That’s exactly what an electric vehicle needs to accelerate quickly. While supercapacitors don’t hold a charge for long, they can absorb regenerative energy from braking.”

The research team, led by Chemical Engineer Dr. David Mitlin of Clarkson University, NY, believed “replacing lithium batteries with hemp would make electric cars and other gadgets” we use in everyday life more sustainable.

Who doesn’t want sustainability?

Especially if you’re one of the lucky ones to have an electric car. Most auto batteries today are made from lithium-ion, an expensive material, so replacing lithium batteries with hemp would make electric cars more sustainable. Now let’s take a look at the benefits of hemp-based batteries, as noted by highhempgradeseed.com: — High Energy Density: Energy density refers to the amount of energy a battery can hold based on its weight.

See the source image

The higher energy density a battery has, the stronger the battery.

A 2016 study conducted by Carbon found that hemp-based batteries contained an energy density of 19.8 Watt-hours per kilogram. — Cost: One of the benefits of using hemp over graphene is that hemp batteries can be made using hemp waste that hemp farmers don’t need. This makes hemp both easy to find and much cheaper than graphene. Over the next decades, the world is going to need a lot of batteries to power its vehicles, homes, and cities.

Cheaper batteries made with hemp could keep the cost of this transition much lower. — Availability: Graphene is a versatile “it” material that is finding its way in everything from silicon chips to solar cells and, of course, batteries. However, one of the biggest downsides of graphene is that it is difficult to make in large quantities. Hemp, on the other hand, can grow to maturity in a few months and is known for its ability to grow in many different types of soil, including soils that cannot sustain other crops. — Superconductivity: Batteries need to conduct electricity with as little resistance as possible.

The more resistant a material is to conductivity, the less efficient the battery will be. Hemp-based batteries showed extremely good conductivity. — Temperature Resistance: The conductivity of hemp batteries remains high even in hot and cold temperatures according to the original study on hemp-based batteries.

This is especially important when considering that this technology could one day find itself in vehicles that need to function in searing summer heat as well as icy winter weather. 

Is there anything hemp can’t do? We’d like to think there’s nothing hemp can’t do. Simply put, hemp has been the past, present and is definitely the future.

Hemp, Inc. has the largest industrial multipurpose hemp processing facility in North America, an 85,000-square foot facility in Spring Hope, N.C. Its mission of providing green solutions that help make the world a better place continues to flourish as the company advances an ever-growing portfolio of revenue- and value-generating synergistic businesses. Hemp may be the salvation in retooling America for greener, more sustainable domestic manufacturing.

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Your Endocannabinoid System and What is it?

OVER THE LAST TWO DECADES, RESEARCH ON THE EFFECTS OF CANNABIS ON THE HUMAN BODY LED TO THE DISCOVERY OF THE ENDOCANNABINOID SYSTEM.

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The endocannabinoid system (ECS) is a network of CB1 and CB2 cell receptors and the molecules that act on them. CB1 receptors are found mostly in tissues of the brain and the central nervous system (CNS).

CB2 receptors are found in the immune system, gastrointestinal tract, retina, and peripheral nervous system.

 

CB1 is expressed in the tissues of both the central nervous system (CNS) and the periphery, with a predominant expression on presynaptic nerves.

Cannabinoid Receptor Type 1

CB2, sometimes referred to as the “peripheral cannabinoid receptor”, is mainly expressed on immune cells but can also be found on other peripheral tissues such as the retina and in the CNS(Croxford and Yamamura 2005; Mackie 2006).

See the source image

  Endocannabinoids act on CB1 and CB2 receptors to regulate core body functions, including metabolism, appetite, sleep, mood, pain, immune function, and muscle movement.

An irregularity of the ECS can result in pain, digestive issues, seizures, mental health concerns, and problems with mobility and balance. Endocannabinoids in the body are degraded by fatty acid amide hydrolase (FAAH).

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Fatty acid amide hydrolase

 

Cannabidiol (CBD), another component of medical marijuana, inhibits FAAH, allowing more naturally occurring endocannabinoids to remain active in the body.

Imbalances of the endocannabinoid system are associated with many diseases, explaining why medical marijuana has a beneficial effect on a variety of medical conditions.

Current research on the endocannabinoid system is seeking new treatments for autoimmune, inflammatory, and neurodegenerative diseases, as well as non-addictive ways to relieve pain.

The delta9-Tetrahydrocannabinol (THC) in marijuana resembles the endocannabinoid molecules, anandamide and 2-Ag, manufactured by the human body.

THC binds with CB1 and CB2 receptors to replace or augment naturally occurring endocannabinoid.

Balancing Your ECS Balancing Your ECS 

CBD has been all the buzz.

The use of CBD products like tinctures, full-spectrum CBD oil, CBD gummies, and CBD soluble water as supplements has skyrocketed. And for good reason. CBD”s purported therapeutic benefits are more than enough to warrant attention.

Though studies are still ongoing, early signs from research indicate it might help with:

Memory – Mental health – Reward circuits – Digestion – Appetite – Immune system – Cardiovascular system – Skin, and much more.

So, how is it really that one compound might hold such a broad range of benefits?

What is the underlying mechanism that might just make all these benefits possible?

To know the answer to that, you first need to know about your Endocannabinoid System (ECS).

The Endocannabinoid System and Balancing Your ECS Unbeknownst to many CBD consumers, taking CBD supplements affects the equilibrium of their endocannabinoid system.

People worldwide are now taking or heavily considering taking CBD because its purported benefits might help them manage some conditions.

However, these benefits in themselves are simply the outcome of improving your bodies’ internal balance.

And that is precisely what the Endocannabinoid system actually does.

What Is the Endocannabinoid System (ECS)?

The Endocannabinoid System (ECS) is a neurotransmitter system that consists of a series of receptors found throughout the mammalian body. These receptors are in some of the most important structures inside your body, from the brain to all peripheral organs.

These particular receptors interact with endogenous cannabinoids/endocannabinoids.

The resulting interaction controls a vast array of physiological functions, including pain, appetite, mood, immune system, memory, and much more.

The Composition of the ECS 

See the source image

Balancing Your ECS – How to Go About It the endocannabinoid system covers the brain to the most important organs

Three different components make up the endocannabinoids systems: Cannabinoid Receptors

There are two kinds of cannabinoid receptors: the CB1 receptors and the CB2 receptors.

Located on cell surfaces, what characterizes cannabinoid receptors is their interactions with their namesake, the cannabinoid compounds.

Said interactions result in the therapeutic benefits people say they experience when taking CBD, which is just one of many cannabinoids.

Since the ECS strives to achieve homeostasis in the body, the therapeutic effects are simply its way to achieve that end.

Usually, the body would use the endocannabinoids it produces on its own to do so.

Yet, by taking CBD products, you can help trigger said effects.

CB1 receptors are in high-density within the brain and the nervous system.

Therefore, they do influence brain functions, such as memory and appetite.

THC, the psychoactive cannabinoid that causes the marijuana high, binds to CB1 receptors hence the ‘high’ you experience with it.

On the other hand, CB2 receptors are most prevalent in the body organs, muscle tissues, immune system, and bones.

They influence the body’s pain managing response, particularly, the anti-inflammatory response.

Endocannabinoids

Endocannabinoids are cannabinoids produced by our own bodies.

They interact with and activate the CB1 and CB2 receptors, with each cannabinoid causing different body changes.

See the source image

Despite their origins, they are remarkably similar in structure to Phyto cannabinoids, the cannabinoids found in plants like industrial hemp or cannabis.

CBD itself is one Phyto cannabinoid found on those plants.

Enzymes ECS enzymes’ primary function is to break down and recycle endocannabinoids, thereby frequently making sure your body achieves homeostasis.

The Fatty acid amide hydrolase (FAAH) enzyme breaks down anandamide, arguably the most important endocannabinoid.

The other major enzyme, the Monoacylglycerol lipase (MAGL) enzyme, breaks down the 2-AG once they have finished their work.

 

What Are the Endocannabinoids?

As mentioned above, endogenous cannabinoids, better known as endocannabinoids, are cannabinoids produced by the body.

The two main endocannabinoids include 2-arachidonoyl glycerol (2-AG) and anandamide (AEA).

2-AG seems to control appetite and the immune system. On the other hand, anandamide regulates mood.

When your body experiences imbalances, the ECS initiates a response to restore physiological balance, thereby achieving homeostasis.

What Is Homeostasis and Why It Is Important

The primary function of ECS is to achieve homeostasis.

So, what is homeostasis?

In simple terms, homeostasis means balance. Regarding health matters, homeostasis refers to achieving balance in our internal environment.

Body organs and, by extension, the human body, functions optimally in specific conditions.

Body homeostasis ensures every part of our body is within the right working range and, therefore, functions correctly.

The strife for homeostasis is evident in bodily functions such as temperature regulation, where you sweat to cool down or shiver to warm up.

The ECS plays a massive role in achieving balance in our internal systems, despite the tremendous external environment changes.

What Might Cause ECS Imbalance?

Many environmental factors and situations put stress on our bodies.

Often times, said stress it so much it overwhelms our systems and throws our internal balance into disarray.

Now more than ever, we are particularly exposed to said factors and situations.

By adequately identifying what might negatively affect us, we have the chance to avoid them or, at least, better control the outcome it has on our internal balance. Here are some of the things you should better control if you are looking to balancing your ECS.

Poor Diet

Research establishes that endocannabinoids produced in the periphery organs control our appetite.

Unfortunately, consuming a diet consisting of high sugar and fat levels can harm the endocannabinoid system, causing an imbalance.

Such diets increase the endocannabinoids produced in the intestines and circulating in the blood.

Consequently, the individual is at risk of developing hyperphagia. Hyperphagia is an abnormal desire for food, causing one to consume larger meals much more frequently.

Thus, making them very likely to become obese. Once someone has a lot of fat mass due to an unhealthy diet, the increased fat cells start to produce more endocannabinoids.

This, in turn, will further their desire to continue to eat a lot frequently. The production of endocannabinoids by fat cells is among the reasons why losing weight is difficult.

Emotional Stress

Research indicates that the ECS system plays a vital role in regulating the stress response. Everyday short-term stress is helpful, and in many ways, it is critical to our survival. When exposed to stress, your body will respond by reducing the anandamide levels.

Thus, causing you to feel stressed, anxious, or agitated. At the same time, stress causes an increase in the production of 2-AG, which reduces pain reception. 2-AG also enhances your cognitive functions, including memory, to help you get out of danger.

However, exposure to chronic stress causes desensitization of CB1 receptors. The high levels of 2-AG overstimulate the CB1 receptors.

(Abstract

The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are N-arachidonylethanolamine and 2-arachidonoylglycerol; together the endocannabinoids and CB1R subserve activity dependent, retrograde inhibition of neurotransmitter release in the brain. Deficiency of CB1 receptor signaling is associated with anhedonia, anxiety, and persistence of negative memories. CB1 receptor-endocannabinoid signaling is activated by stress and functions to buffer or dampen the behavioral and endocrine effects of acute stress. Its role in regulation of neuronal responses is more complex. Chronic variable stress exposure reduces endocannabinoid-CB1 receptor signaling and it is hypothesized that the resultant deficiency in endocannabinoid signaling contributes to the negative consequences of chronic stress. On the other hand, repeated exposure to the same stress can sensitize CB1 receptor signaling, resulting in dampening of the stress response. Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endocannabinoid/CB1 receptor signaling provides resilience against the development of stress-related pathologies.)

The body compensates this by desensitizing or reducing the number of CB1 receptors. Consequently, this creates an imbalance in the ECS system. Disease Research linking ECS imbalance to arthritis, depression, PTSD, Parkinson’s disease, schizophrenia, and other diseases is underway. That said, there are indications that certain conditions might have more than a casual relationship with ECS imbalance.

This theory might explain why some patients might better manage their ailments by taking CBD products to rebalance the ECS.

In other instances, the ECS imbalance seems to cause the disease.

Drugs Studies indicate some pharmaceutical and recreational drugs, including alcohol, stimulate an increase in endocannabinoids’ production.

Thus, it might overstimulate cannabinoid receptors, especially CB1 receptors. Consequently, the body downregulates receptors as a compensation mechanism, thereby creating an imbalance in the system.

Your Genetics

There are cases where individuals have inherent ECS unbalances built into their genetic makeup.

Unfortunately, these are something they cannot get rid of completely.

For instance, a 2015 discovery reported in the New York Times indicates that approximately 20% of Americans have a mutation that degrades the anandamide.

Such individuals have an inherent imbalance that compromises their response to stress while increasing their risk of suffering from obesity.

The Best Methods for Balancing Your ECS

Balancing Your ECS – How to Go About physical exercise is one of the most fun ways of balancing your ECS

When such imbalances arise, one possible way of achieving homeostasis is to supplement your diet with CBD products.

CBD interacts with CB1 receptors, thereby supplementing the endocannabinoids in your body that are not enough to restore balance at a given moment.

The compound also boosts the endogenous cannabinoids by reducing their breakdown.

By preventing the degradation of endocannabinoids, CBD ensures your body has an ample supply of homeostasis-inducing compounds. Aside from supplementing with CBD, there are also other means of balancing your ECS, including: Physical Exercising

Engaging in physical exercise is known for its benefits in maintaining a healthy weight level.

Additionally, exercise can also elevate the anandamide levels in your blood, which rebalances the ECS. The increased 2-AG in your blood also enhances your ability to manage pain and reduce anxiety and stress, improving your mood.

Taking Herbs

Some herbs and teas contain compounds that enhance ECS balancing. Herbs containing the terpene beta-caryophyllene such as cloves, oregano, black pepper, and cinnamon can help balance the ECS.

This compound only stimulates the CB2 receptors and helps combat inflammation. Fasting While unconventional, fasting can help balance your ECS. Being in a fasted state enhances increases the 2-AG levels in your body as your body stocks hunger.

The elevated amount of 2-AG will still yield anandamide’s associated benefits, including inflammation and anxiety relief. Eating A Healthy Diet Consuming a poorly-balanced diet consisting of high omega-6 fatty acids induces imbalances in your ECS.

To counter this, you should prioritize consuming a balanced diet with an ample supply of omega-3 fatty acids. Fatty acids from hemp milk, fish and fish oil, walnuts, chia seeds, and flaxseeds end up converting into endocannabinoids.

Thus, help you in balancing your ECS. Detoxing Abusing alcohol, THC, and other recreational and pharmaceutical drugs overstimulates CB1 receptors, thus, causing desensitization. You can counter these effects by detoxing.

Evidence suggests that the CB1 receptors can return to their natural state after months of detoxing. By detoxing and abstaining from drug abuse, your ECS will regain some balance in time.

Meditating

As mentioned above, chronic stress is one of the most common causes of ECS imbalance.

Thus, it’s better to relax. There are no studies yet on whether meditating can help balance your ECS.

However, some reports show mindful meditation as effective in quelling anxiety and stress, something that definitively counts as ‘relaxing.’

Enjoying Some Sunlight Basking in the sun is vital for more than getting some Vitamin D.

Solar UV light is essential in the production of 2-AG, especially during winter months.

Elevating 2-AG by soaking some sunlight can help rebalance your ECS system.

Balancing Your ECS –

The Takeaway

The modern world undoubtedly offers us an ever-increasing set of choices of things that might end up causing an ECS imbalance. It is then up to us to take matters into our own hands and be mindful of our habits.

Regularly engaging in habits that help balancing your ECS and limiting those that do not might go a long way in maintaining our internal balance. And with that, helps us feel better in our day to day lives.

Also, if you need to have a little extra help in balancing your ECS, there’s always CBD products.

Supplementing your endocannabinoids level with a Phyto cannabinoid may boost your ECS back into balance.

Just remember to talk with a doctor before taking CBD, especially if you are already on some other medication.

 

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Inspirational Technologies – is Committed to Your Health Wellness Beauty and Enrichment
Reporting on Today’s Internal Botanical and Skin Product Benefits

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envisioned. Our Platform Uses HEMP as an Agricultural

Focal Point, deserving of research, development and the

4 Hemp key points Hemp Health Hope and Happiness.”

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It’s In the Numbers for Cannabis. In the US, Beverages and Pre-Rolls saw the strongest year over year growth rates in 2021

Key takeaways: In the US, Beverages and Pre-Rolls saw the strongest year over year growth rates in 2021, while the Tincture & Sublingual category saw a decline in sales.

On the other hand, Tincture & Sublingual products in Canada, which were released in late 2020 with other ‘Cannabis 2.0’ products, saw over 3000% growth year over year.

See the source image

Flower market share is in decline in both the US and Canada. Sales from female consumers in the US have increased 55%, while sales from male consumers have increased 49%.

Gen Z consumers are quickly aging into the market, with US market share to this age group more than doubling over the last two years, from 8.3% to 15%.

See the source image

Vapor Pen wallet share decreases with customer age, while Edible wallet share increases with customer age.

Meanwhile, Pre-Roll wallet share is remarkably constant across age groups, indicating that the convenience and familiarity of a pre-rolled joint has universal appeal.

Both Gen Z and Millennial females logged much higher sales shares in Canada last quarter than their American counterparts. In fact, female customers overall contributed 36.7% of total sales in Canada while in America that value was only 32.6%.

Those are the trends and here are the products. When exploring product categories, reports found that certain categories have been more successful than others in the US and Canada.

  This is likely caused by a steady decrease in customer participation in the category, rather than a decreased spend among customers who prefer flower. 

Image result for cbd Beverage category

The Beverage category is one of few product categories that saw positive market share growth in both the US and Canada between 2020 and 2021. This was driven by an increase in basket penetration over time.

 

 

 

 

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Inhalers, Patches and Smart Cannabis Dosing, Oh My! RYAH Group ‘One to Watch’

RYAH Group Inc. Is ‘One to Watch’

The company is a leading developer of dose-measuring IoT devices connected with its turn-key platform designed to aggregate and correlate HIPPA-compliant data, suitable to all participants in the patient treatment cycle. The company also specializes in customized, fully integrated, mobile applications and APIs, specifically designed to meet the needs of clinics, clinical trials, government and university research centers, for experimentation and treatment validation – significantly reducing variations in patient-related trials. RYAH unlocks data in the complete therapeutic plant lifecycle – from seed to consumption.

RYAH Group is a technological leader in the plant-based treatment market with its unique combination of proprietary IoT devices and data analytics, supported by patented AI technology

  • The company’s products pair a growing ecosystem of therapeutic plants with top-rated apps, devices and services
  • RYAH offers a complete remote dosage delivery and dose-monitoring platform based on data-driven analytics supported by prescribing doctors and their patients
  • The company is finalizing its anticipated listing on the Canadian Securities Exchange
  • RYAH holds a unique position on the $100.3 billion medical plant market, with the potential to capture footholds in both the IoT and Data Intelligence industries

Since it began developing and commercializing its smart inhaler solution in 2018, the company has evolved a complete IoT device and data analytics platform that includes multiple delivery mechanisms, designed to capture anonymous patient dosing and feedback, combined with detailed strain analytics, enabling customized dosing regiments. The company has secured numerous partnerships across the globe, including establishing a footprint in the UK, USA, Australia and Canada, and it has closed several deals in the European Union, as well. The company’s Smart-Inhaler has been selected as the dose-measurement, dose-control and data analytics platform for a UK pain management study and one of the world’s most ambitious and largest clinical trials ever to be conducted in cannabis. Product Portfolio The company’s current portfolio incorporates an ecosystem of IoT products, each consisting of three elements: the device, the medicine-carrying component and the mobile application. The product line currently includes a Smart Dry-Herb Dose-Measuring Inhaler in the commercial stage, a Smart Transdermal Patch in the production stage and a Smart Liquid Dispensing Pen in the prototype stage.

RYAH Smart-Inhaler

The RYAH Inhaler is the first dry-herb inhaler that allows users to track and control how much is inhaled, providing consistent and predictable results. This inhaler connects with the RYAH Health App, which features stat-tracking and presets for temperatures and dosages, all of which can be customized to individual needs and doctor recommendations, as well as a post-session review mechanism that allows the collection of session data and feedback for further efficacy analysis for customized dosing capabilities. RYAH’s proprietary stainless-steel cartridges for the inhaler use QR technology that contains lab testing and grower information pertaining to the specific strain, thereby mitigating elicit product use and enabling completely transparent remote medicinal analytics, from seed to consumption. In addition, the RYAH Cartridges provide a unique closed-loop recurring revenue opportunity for the company, as the RYAH Inhaler only works with this type of proprietary cartridges that licensed partners fill with medicine. The partners benefit from all the back-end data, providing them access to consumption habits, statistics and other data on patient preferences.

RYAH Smart-Patch

See the source image

The RYAH Smart Transdermal Patch is a lightweight, reusable, mobile-controlled patch used for site-specific therapies. The Patch is an Electronic Topical Delivery Patch system intended for recommendation and administration by pain relief professionals and physical and occupational therapists. The patch data and the heating element is completely IoT and controlled by RYAH’s proprietary smartphone applications, which allows scheduling and ‘boosting’ medicine release, on-demand.

RYAH Smart-Pen

The RYAH Pen is an app-controlled liquid dispenser designed to provide a precise mix of up to three medicine components to create an ‘entourage effect’, enabling customized, wide-spectrum recommendation opportunities by licensed clinicians. The Smart-Pen will feature cartridges that contain CBD, THC and other isolates such as flavonoids or vitamins, or other solutions. There is a built-in mechanism designed to control usage based on recommended dosing schedules. RYAH MD RYAH MD serves as a remote and interactive patient-doctor collaboration and dosing administration platform. Doctors can remotely set dosage amounts for their patients, creating digital prescriptions for the RYAH IoT devices and tracking patient usage in real-time. RYAH MD offers features that include real-time monitoring, appointment booking, doctor-patient video calls and science-based strain recommendations, as well as promoting a better understanding of the effects and benefits of those recommendations among patients. Information is gathered from all of the RYAH devices.

PotBot App

The PotBot App is a medical cannabis education mobile application that leverages patented AI technology to capture structured and unstructured data to assist patients in learning about various treatments in plant-medicine based on their efficacy goals.

The PotBot App is currently one of the top-rated medical cannabis educational mobile applications on the Apple App Store in the United States, with over 300,000 downloads. Through the combination of peer-reviewed and empirical data, the PotBot App provides detailed information on the targeted and tested cannabinoid levels and associated strains from cannabis patients.

The result is personalized and driven by data to inform patients of potential product matches associated with similar ailments and efficacy goals.

Market Outlook RYAH holds a unique position in the $100.3 billion medical plant market, with the potential to capture and capitalize on growth opportunities made available by both the IoT and Data Intelligence sectors. In 2018, the global IoT market was valued at $212.1 billion, and it is expected to grow exponentially to $1.3 trillion by 2026, registering a CAGR of 25.68%. Management Team Dr. Boris Goldstein, Ph.D., is the founder and Chairman of RYAH Group. He is a seasoned entrepreneur, investment banker and venture capitalist. He started his career as the founder of Software House HT, which grew into a worldwide corporation with over 40 offices in 17 countries. Since then, Goldstein has founded and served on the boards of directors and advisory boards for numerous companies in Silicon Valley and Silicon Alley. Goldstein brings experience in fundamental research, investment and technology, authoring multiple patents and books. Gregory Wagner, MBA, is Chief Executive Officer and Director of RYAH Group. He has over 20 years of experience in global financial markets and entrepreneurship. Wagner has held executive roles in the United States and London. He has co-founded and built several startups from the ground up. His current licensures and degrees include FINRA Series 7, 63, 24 and 55, as well as an MBA from Fordham University. Wagner received a Certification in Innovation and Strategy from Harvard University.

TORONTO, ON February 17, 2022 / RYAH Group, Inc.  is pleased to announce a collaboration with the University of Milan, Italy to conduct permeation and effectiveness testing of a new wellness line of topical patches developed by RYAH and specifically designed for the RYAH Smart Patch system.

University of Milan, Italy



A team of scientists at the University will be conducting various tests (1) to determine permeation effectiveness of vitamin and nutraceutical patches as an alternative slow-release, non-digested solution to consumer intake, and (2) using the RYAH Smart Patch ‘boost capability’ to monitor and calculate the effectiveness precise, intermittent heat has on the delivery of the patch loadings. The project is being led by Professor Antonella Casiraghi, PhD, Researcher and Professor in charge of formulations and pharmaceutical technology, and Professor Paola Minghetti, Head of the Faculty of Pharmacy at the University of Milan. The project will be coordinated locally by Andrea Ferrari, Head of RYAH European Business Development and based in Italy.

The global nutraceuticals market is anticipated to reach US $441.7billion by 2026 with a CAGR of 7.8%. In 2021, the United States accounted for 34.57% of the global Nutraceutical market or $104.5 billion. Nutraceuticals are significantly increasing in popularity in recent years as a result of the rise of preventative care, the COVID-19 pandemic, changes in various trends including changing lifestyles, evolving dietary habits, aging population, and increased life expectancy.

There have been a number of research papers that discuss the potential for increased permeation of certain topical formulations when exposed to a reasonable increase in heat. A 2017 paper, published in Expert Opinion on Drug Delivery, suggested heat as a possible design feature to improve transdermal drug delivery and effectiveness.

The RYAH Smart Patch is an IoT powered connected device that provides deep insights, giving consumers the ability to monitor and track their patch formulation usage, body location of patch, length of use, and personal effectiveness. The Smart Patch also offers a pre-scheduled or ad hoc ‘boost’ capability for specific formulations that may experience increased permeability with a precise, controlled, and gentle heating capability.

“We are pleased to be engaging in another meaningful research project with our partners at the University of Milan. This new project follows an ongoing, ambitious collaboration with the Department of Chemical Analysis led by Professor Gabriella Roda, with the objective to publish a scientific study on the performance of the RYAH Smart Medical inhaler. RYAH remains committed to providing effective delivery solutions combined with powerful data insights across a wide range of medicines, vitamins and nutraceuticals. The development of our wellness line combined with the RYAH Smart Patch system, is a perfect example of our commitment to keep current with important consumer trends in this expanding industry,” said Gregory Wagner, C.E.O. of RYAH Group, Inc.

 

 

 

 

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